Mendelian Randomization Study of Obesity and Cerebrovascular Disease

Autor: Martin Dichgans, Jordi Merino, Rainer Malik, Jose C. Florez, Catherine Sudlow, Bailey Montgomery, Jonathan Rosand, Sandro Marini, Dipender Gill, Christopher D. Anderson

Publikováno v: Annals of neurology 87(4), 516-524 (2020). doi:10.1002/ana.25686
Marini, S, Merino, J, Montgomery, B E, Malik, R, Sudlow, C L, Dichgans, M, Florez, J C, Rosand, J, Gill, D & Anderson, C D 2020, ' Mendelian randomization study of obesity and cerebrovascular disease ', Annals of Neurology . https://doi.org/10.1002/ana.25686
Ann Neurol

Objective To systematically investigate causal relationships between obesity and cerebrovascular disease and the extent to which hypertension and hyperglycemia mediate the effect of obesity on cerebrovascular disease. Methods We used summary statisti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f4cfd4a82b54082ab08ccaaa4e0043
https://doi.org/10.1002/ana.25686

Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease

Autor: Joseph-Mathurin, Nelly, Wang, Guoqiao, Massoumzadeh, Parinaz, Hornbeck, Russ C, Allegri, Ricardo F, Ances, Beau M, Berman, Sarah B, Brickman, Adam M, Brooks, William S, Cash, David M, Chhatwal, Jasmeer P, Chui, Helena C, Kantarci, Kejal, Correia, Stephen, Cruchaga, Carlos, Farlow, Martin R, Fox, Nick C, Fulham, Michael, Ghetti, Bernardino, Graff-Radford, Neill R, Johnson, Keith A, Karch, Celeste M, Laske, Christoph, Jack, Clifford R, Lee, Athene K W, Levin, Johannes, Masters, Colin L, Noble, James M, O'Connor, Antoinette, Perrin, Richard J, Preboske, Gregory M, Ringman, John M, Rowe, Christopher C, Salloway, Stephen, McDade, Eric, Saykin, Andrew J, Schofield, Peter R, Shimada, Hiroyuki, Shoji, Mikio, Suzuki, Kazushi, Villemagne, Victor L, Xiong, Chengjie, Yakushev, Igor, Morris, John C, Bateman, Randall J, Hassenstab, Jason, Benzinger, Tammie L S, Network, Dominantly Inherited Alzheimer, Blazey, Tyler M, Gordon, Brian A, Su, Yi, Chen, Gengsheng

Publikováno v: Neurology 96(12), e1632-e1645 (2021). doi:10.1212/WNL.0000000000011542
Neurology
article-version (Version of Record) 3

ObjectiveTo investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds and characterize individuals at high risk for developing hemorrhagic amyloid-related imaging abnormality (ARI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edb893204d0bbc0bc95a1a0a2549e28
https://pub.dzne.de/record/155387

Characteristics in Non-Vitamin K Antagonist Oral Anticoagulant-Related Intracerebral Hemorrhage

Autor: Michael P. Schwarz, Tobias Engelhorn, Miriam Bauer, Karl Georg Haeusler, Wolfgang Müllges, Henning Stetefeld, Sebastian Stösser, Markus Horn, Peter D. Schellinger, Gerhard F. Hamann, Ruben U. Knappe, Joachim Röther, Stefan T. Gerner, Jörg Glahn, Armin J. Grau, Jochen A. Sembill, Hauke Schneider, Dirk Bahner, Jan C. Purrucker, J Claßen, Gereon R. Fink, Christian Dohmen, Manuel Hagen, Anna Lena Fisse, Peter Michels, Hansjörg Bäzner, Martin Nueckel, Hagen B. Huttner, Hermann Neugebauer, Henning Schwert, Timolaos Rizos, Hannes Lücking, Arnd Dörfler, Maximilian I. Sprügel, Peter A. Ringleb, Otto W. Witte, Johannes Schurig, Albrecht Günther, Sarah Zweynert, Jan Sobesky, Christian Urbanek, Frank Erbguth, Matthias Endres, Jan Rahmig, Fahid Alshammari, Joji B. Kuramatsu, Georg Hagemann, Florian Rakers, Frederick Palm, Heinz Reichmann, Stefan Schwab, Dominik Michalski, Johannes C. Wöhrle, Jens Volkmann, Albert C. Ludolph, Gernot Reimann, Peter Vajkoczy, Ulrich J. Knappe, Jens Minnerup, Anna-Lena Schubert, Peter Kraft

Publikováno v: Stroke 50(6), 1392-1402 (2019). doi:10.1161/STROKEAHA.118.023492

Background and Purpose— Given inconclusive studies, it is debated whether clinical and imaging characteristics, as well as functional outcome, differ among patients with intracerebral hemorrhage (ICH) related to vitamin K antagonists (VKA) versus n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97753dc74209e8fd3a8409433a1e2e7a

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants

Autor: Rutten-Jacobs, Loes Ca, Larsson, Susanna C, Malik, Rainer, Rannikmäe, Kristiina, MEGASTROKE consortium, International Stroke Genetics Consortium, Sudlow, Cathie L, Dichgans, Martin, Markus, Hugh S, Traylor, Matthew

Publikováno v: The BMJ
The BMJ 363, k4168 (2018). doi:10.1136/bmj.k4168

Objective To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Design Prospective population based cohort study. Setting UK Biobank Study, UK. Participants 306 473 men and women, aged 40-73 years, recruit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::18537aa5e5253ffc5c96a13d329709fd
https://pubmed.ncbi.nlm.nih.gov/30355576

Intracerebral Hemorrhage and Outcome After Thrombolysis in Stroke Patients Using Selective Serotonin-Reuptake Inhibitors

Autor: Scheitz, Jan F, Turc, Guillaume, Wiest, Roland, Rocco, Andrea, Sibolt, Gerli, Gensicke, Henrik, Endres, Matthias, Martinez-Majander, Nicolas, Béjot, Yannick, Nederkoorn, Paul J, Oppenheim, Catherine, Arnold, Marcel, Kujala, Linda, Engelter, Stefan T, Strbian, Daniel, Nolte, Christian H, TRISP Collaboration, Polymeris, Alexandros A, Heldner, Mirjam R, Zonneveld, Thomas P, Erdur, Hebun, Curtze, Sami, Traenka, Christopher, Brenière, Céline

Publikováno v: Stroke 48(12), 3239-3244 (2017). doi:10.1161/STROKEAHA.117.018377

Background and Purpose— Selective serotonin-reuptake inhibitors (SSRIs) impair platelet function and have been linked to a higher risk of spontaneous intracerebral hemorrhage—an association that may be augmented by oral anticoagulants (OAC). We a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95144642036b18ca6ffd4abd1ba28c91