Zobrazeno 1 - 10
of 3 349
pro vyhledávání: '"epcam"'
Autor:
Debasmita Dutta, Ashique Al Hoque, Brahamacharry Paul, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay, Priyanka Boro, Benny Abraham Kaipparettu, Biswajit Mukherjee
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-29 (2024)
Abstract Background Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-inducing effects on various cancers. However, its poor solubility and off-target activity have limited its utili
Externí odkaz:
https://doaj.org/article/9280bd3bfc60492fb7d8ce900d586837
Autor:
Beatrice Belmonte, Giovanni Di Lorenzo, Alessandro Mangogna, Barbara Bortot, Giorgio Bertolazzi, Selene Sammataro, Simona Merighi, Anna Martorana, Gabriella Zito, Federico Romano, Anna Giorgiutti, Cristina Bottin, Fabrizio Zanconati, Andrea Romano, Giuseppe Ricci, Stefania Biffi
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Endometriosis is a gynecological disease characterized by the presence of endometrial tissue in abnormal locations, leading to severe symptoms, inflammation, pain, organ dysfunction, and infertility. Surgical removal of endometrio
Externí odkaz:
https://doaj.org/article/4d6749387fc843eb9f92e95d8cc5daad
Autor:
Sushree Shankar Panda, Chi-Chiu Lee, Khamushavalli Geevimaan, Kai-Chi Chen, Shung-Haur Yang, Chia-Ning Shen, Wei-Chun HuangFu, Han-Chung Wu
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Epithelial cell adhesion molecule (EpCAM) has been widely studied as a tumor antigen due to its expression in varieties of solid tumors. Moreover, the glycoprotein contributes to critical cancer-associated cellular functionalities
Externí odkaz:
https://doaj.org/article/ebea9f77cac94d27b2c3a20d54f81785
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Thyroid cancer (TC) is the most common endocrine malignancy. Nowadays, undifferentiated thyroid cancers (UTCs) are still lethal, mostly due to the insurgence of therapy resistance and disease relapse. These events are believed to
Externí odkaz:
https://doaj.org/article/a5b84c9754e34fd5abe25fc05a072b92
Autor:
Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTEpithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays several roles in cancer biology. EpCAM is an attractive therapeutic target because of its expression in most solid tumors. However, targeting EpCAM has been
Externí odkaz:
https://doaj.org/article/7fc31e7a3b674b338e4ac1b2672d0edf
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Epithelial cell adhesion molecule negative circulating tumor cells (EpCAM- CTCs) and EpCAM positive CTCs (EpCAM + CTCs) have different biological characteristics. Therefore, the isolation of EpCAM + CTCs and EpCAM- CTCs is a new strategy to study the
Externí odkaz:
https://doaj.org/article/41a1e43eac6a49ad8d01adc996b032ef
Autor:
Ya Nie, Ting Lin, Yanhong Yang, Wanwan Liu, Qing Hu, Guibin Chen, Li Huang, Huijuan Wu, Cunjie Kong, Zili Lei, Jiao Guo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
BackgroundThe genetic factors play important roles on the pathogenesis of inflammatory bowel disease (IBD). EpCAM is highly expressed in the intestinal epithelium. It is still unclear if the decrease or somatic mutation of EpCAM could cause IBD.Metho
Externí odkaz:
https://doaj.org/article/1a420963ea2646aa968c49bfc1231583
Autor:
Takuto Nosaka, Yosuke Murata, Yu Akazawa, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34441- (2024)
Circulating tumor cells (CTCs) are noninvasive biomarkers that can indicate the therapeutic response and prognosis. The study aimed to investigate the cellular characteristics of CTCs focusing on monitoring during atezolizumab and bevacizumab (Atezo-
Externí odkaz:
https://doaj.org/article/6d8aea74a5f848d980e736a22e7fa0d8
Autor:
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeut
Externí odkaz:
https://doaj.org/article/9a0782a3db1c490fbcc5b38f1bad9a21
Autor:
Sitian He, Peng Liu, Yongjun Wu, Mette Ø. Agerbæk, Ali Salanti, Leon W. M. M. Terstappen, Pascal Jonkheijm, Michiel Stevens
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9816 (2024)
Circulating tumor cells (CTCs) are detected in approximately 30% of metastatic non-small-cell lung cancer (NSCLC) cases using the CellSearch system, which relies on EpCAM immunomagnetic enrichment and Cytokeratin detection. This study evaluated the e
Externí odkaz:
https://doaj.org/article/4e159899e03244e49334ab01198cee2d