Výsledky vyhledávání - "enzymology [Dendritic Spines]"

Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo

Autor: Christian K E, Jung, Martin, Fuhrmann, Kamran, Honarnejad, Fred, Van Leuven, Jochen, Herms

Publikováno v: Journal of neurochemistry 119(5), 1064-1073 (2011). doi:10.1111/j.1471-4159.2011.07503.x

Mutations in presenilins are the major cause of familial Alzheimer's disease (FAD), leading to impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Presenilins are the catalytic subunits of γ-secretase, which it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7cc36cf2d8fb0d21c4a4e37b5e40c24b
https://pub.dzne.de/record/136375

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Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway

Autor: Steffen Burgold, Tobias Bittner, Harald Steiner, Gerda Mitteregger, Christian Haass, Christiane Volbracht, Hans A. Kretzschmar, Christian K.E. Jung, Jochen Herms, Martin Fuhrmann

Publikováno v: Journal of Neuroscience; Vol 29
The journal of neuroscience 29(33), 10405-10409 (2009). doi:10.1523/JNEUROSCI.2288-09.2009

Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder. It is characterized by the invariant accumulation of the β-amyloid peptide (Aβ), which mediates synapse loss and cognitive impairment in AD. Current therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db553ccd4b1687df00e63b58f881a36
https://pubmed.ncbi.nlm.nih.gov/19692615

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