Zobrazeno 1 - 10
of 13
pro vyhledávání: '"enzymology [Brain]"'
Autor:
Brunialti, Electra, Villa, Alessandro, Mekhaeil, Marianna, Mornata, Federica, Vegeto, Elisabetta, Maggi, Adriana, Di Monte, Donato A., Ciana, Paolo
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Journal of neuroinflammation 18(1), 220 (2021). doi:10.1186/s12974-021-02272-2
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Journal of neuroinflammation 18(1), 220 (2021). doi:10.1186/s12974-021-02272-2
Background Homozygotic mutations in the GBA gene cause Gaucher’s disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson’s disease. In homozygosis, these mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dae17a70792272350bc36e176b83fa18
http://europepmc.org/articles/PMC8459568
http://europepmc.org/articles/PMC8459568
Autor:
Elodie Chabrol, Roger Prades, Anatoly Korotkov, Oleg Senkov, Shaobo Jia, Johannes C. Baayen, Jan A. Gorter, Diede W. M. Broekaart, Alexander Dityatev, Wytse J. Wadman, Sander Idema, Jasper J. Anink, Alexandra Bertran, Erwin A. van Vliet, Eleonora Aronica, Albert J. Becker, James D. Mills, Jesús Seco, Anika Bongaarts, Teresa Tarragó
Publikováno v:
Journal of Clinical Investigation, 131(1):e138332. The American Society for Clinical Investigation
Broekaart, D W M, Bertran, A, Jia, S, Korotkov, A, Senkov, O, Bongaarts, A, Mills, J D, Anink, J J, Seco, J, Baayen, J C, Idema, S, Chabrol, E, Becker, A J, Wadman, W J, Tarragó, T, Gorter, J A, Aronica, E, Prades, R, Dityatev, A & van Vliet, E A 2021, ' The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects ', Journal of Clinical Investigation, vol. 131, no. 1, e138332 . https://doi.org/10.1172/JCI138332
J Clin Invest
The journal of clinical investigation 131(1), e138332 (2021). doi:10.1172/JCI138332
Journal of clinical investigation, 131(1):e138332. The American Society for Clinical Investigation
The journal of clinical investigation, 131(1):e138332. The American Society for Clinical Investigation
Broekaart, D W M, Bertran, A, Jia, S, Korotkov, A, Senkov, O, Bongaarts, A, Mills, J D, Anink, J J, Seco, J, Baayen, J C, Idema, S, Chabrol, E, Becker, A J, Wadman, W J, Tarragó, T, Gorter, J A, Aronica, E, Prades, R, Dityatev, A & van Vliet, E A 2021, ' The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects ', Journal of Clinical Investigation, vol. 131, no. 1, e138332 . https://doi.org/10.1172/JCI138332
J Clin Invest
The journal of clinical investigation 131(1), e138332 (2021). doi:10.1172/JCI138332
Journal of clinical investigation, 131(1):e138332. The American Society for Clinical Investigation
The journal of clinical investigation, 131(1):e138332. The American Society for Clinical Investigation
Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba82be954946800f57c88d15af875b95
https://research.vumc.nl/en/publications/7ff5ba3a-afb5-4d69-ba8a-c911324843ff
https://research.vumc.nl/en/publications/7ff5ba3a-afb5-4d69-ba8a-c911324843ff
Autor:
Paul Saftig, Stefan F. Lichtenthaler
Publikováno v:
Progress in neurobiology 135, 1-20 (2015). doi:10.1016/j.pneurobio.2015.10.003
Proteins belonging to the 'A Disintegrin And Metalloproteinase' (ADAM) family are membrane-anchored proteases that are able to cleave the extracellular domains of several membrane-bound proteins in a process known as 'ectodomain shedding'. In the cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7955ee2c07aeb129e6b2975ff42610
https://doi.org/10.1016/j.pneurobio.2015.10.003
https://doi.org/10.1016/j.pneurobio.2015.10.003
Autor:
Benjamin Schusser, Michaela Schweizer, Daniela Dreymueller, Stefan F. Lichtenthaler, Dirk Montag, Julia Herber, Sebastian Wetzel, Paul Saftig, Peer-Hendrik Kuhn, Elisabeth Kremmer, Andreas Ludwig, Ulrike Müller, Stefan Bräse, Alessio Colombo, Ute Schepers
Publikováno v:
eLife, Vol 5 (2016)
eLife 5, e12748 (2016). doi:10.7554/eLife.12748
eLife, 5 (JANUARY2016), e12748
eLife, 5:e12748
eLife 5:e12748 (2016)
eLife
eLife 5, e12748 (2016). doi:10.7554/eLife.12748
eLife, 5 (JANUARY2016), e12748
eLife, 5:e12748
eLife 5:e12748 (2016)
eLife
Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191b399eaeb467521bf601203b436eb5
https://elifesciences.org/articles/12748
https://elifesciences.org/articles/12748
Autor:
Alienor Ragot, Pauline Delage, Andre Fischer, Hongyu Zhang, Xavier Leinekugel, Yoon H. Cho, Jean Vincent, Susanna Pietropaolo, Bernadette Allinquant
Publikováno v:
Brain and behavior 5(9), n/a-n/a (2015). doi:10.1002/brb3.361
Brain and Behavior
Brain and Behavior
Introduction The inhibition of the Histone Deacetylase 6 (HDAC6) increases tubulin acetylation, thus stimulating intracellular vesicle trafficking and brain-derived neurotrophic factor (BDNF) release, that is, cellular processes markedly reduced in H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451b8d8f8545473d9a494a80d09450c0
https://doi.org/10.1002/brb3.361
https://doi.org/10.1002/brb3.361
Autor:
Andre Fischer
Publikováno v:
Neuropharmacology 80, 95-102 (2014). doi:10.1016/j.neuropharm.2014.01.038
Alzheimer' s disease (AD) is the most common form of dementia causing an increasing emotional and economical burden to our societies. Although much progress has been made regarding the molecular mechanisms that underlie AD pathogenesis effective ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bad428cc344202042ae5e7db9cf1bb
https://pubmed.ncbi.nlm.nih.gov/24486385
https://pubmed.ncbi.nlm.nih.gov/24486385
Autor:
Wataru Araki, Toru Kita, Ryosuke Takahashi, Sayaka Saijo, Kiyoto Nishi, Takeshi Kimura, Eiichiro Nishi, Stefan F. Lichtenthaler, Hidekazu Tomimoto, Yoshinori Hiraoka, Tatsuhiko Matsuoka, Mikiko Ohno
Publikováno v:
Neurobiology of aging 35(1), 213-222 (2014). doi:10.1016/j.neurobiolaging.2013.07.014
Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f459f6363421f016701b81396ad78adc
https://pubmed.ncbi.nlm.nih.gov/24099785
https://pubmed.ncbi.nlm.nih.gov/24099785
Autor:
Ellen Gelpi, Annett Halle, Markus P. Kummer, Daisy Axt, Andrea Delekate, Anita Remus, Douglas T. Golenbock, Te-Chen Tzeng, Andrea Stutz, Eicke Latz, Martin Korte, Stephanie Schwartz, Ana Vieira-Saecker, Michael T. Heneka, Angelika Griep
Publikováno v:
Nature 493(7434), 674-678 (2012). doi:10.1038/nature11729
Nature
Nature
Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-beta peptide drives cerebral neuroinflammation by activating microglia. Indeed, amyloid-beta activation of the NLRP3 inflammasome in microglia is fundamental for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f0acc3be46a195a5da2f36c54b2d1b
https://pub.dzne.de/record/136774
https://pub.dzne.de/record/136774
Autor:
Michael Täger, Dirk Reinhold, Alexander Goihl, Karsten Nordhoff, Peter Dr. Röhnert, Frank Striggow, Patrick Emmerlich, Sabine Wrenger, Ute Bank, Siegfried Ansorge, Werner Schmidt
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 9, Iss 1, p 44 (2012)
Journal of neuroinflammation 9(1), 557 (2012). doi:10.1186/1742-2094-9-44
Journal of Neuroinflammation, Vol 9, Iss 1, p 44 (2012)
Journal of neuroinflammation 9(1), 557 (2012). doi:10.1186/1742-2094-9-44
Background Cerebral inflammation is a hallmark of neuronal degeneration. Dipeptidyl peptidase IV, aminopeptidase N as well as the dipeptidyl peptidases II, 8 and 9 and cytosolic alanyl-aminopeptidase are involved in the regulation of autoimmunity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1897c8c4be852a105431660d6dc68c
https://pubmed.ncbi.nlm.nih.gov/22373413
https://pubmed.ncbi.nlm.nih.gov/22373413
Autor:
Christian Haass, Sonja Zilow, Claudia Prinzen, Ann-Katrin Ludwig, Dominik Buell, Stefan F. Lichtenthaler, Brigitte Nuscher, Sven Lammich, Falk Fahrenholz
Publikováno v:
The journal of biological chemistry 285(21), 15753-15760 (2010). doi:10.1074/jbc.M110.110742
Proteolytic processing of the amyloid precursor protein by alpha-secretase prevents formation of the amyloid beta-peptide (Abeta), which is the main constituent of amyloid plaques in brains of Alzheimer disease (AD) patients. alpha-Secretase activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5f04b28db66df3106a7fd4d336910b
https://europepmc.org/articles/PMC2871442/
https://europepmc.org/articles/PMC2871442/