Deletion of CD38 mitigates the severity of NEC in experimental settings by modulating macrophage-mediated inflammation.

Autor: Ma Y; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China., Zhang Y; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China., Liu X; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China., Yang X; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China; Department of Animal Center, Chongqing Medical University, Chongqing, China., Guo H; Department of Anesthesiology, Children's Hospital of Chongqing Medical University, Chongqing, China., Ding X; Department of Animal Center, Chongqing Medical University, Chongqing, China; Department of General Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China., Ye C; School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China., Guo C; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China. Electronic address: guochunbao@foxmail.com.

Publikováno v: Redox biology [Redox Biol] 2024 Nov; Vol. 77, pp. 103336. Date of Electronic Publication: 2024 Sep 19.

Dysbiosis of the initial stool microbiota increases the risk of developing necrotizing enterocolitis or feeding intolerance in newborns.

Autor: Chae H; Department of Laboratory Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea., Kim SY; Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea., Kang HM; Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea., Im SA; Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Youn YA; Department of Pediatrics, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. lea732@hanmail.net.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 18; Vol. 14 (1), pp. 24416. Date of Electronic Publication: 2024 Oct 18.

Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium.

Autor: Subramanian S; Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Geng H; Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Wu L; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA., Du C; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Peiper AM; Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Bu HF; Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Chou PM; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wang X; Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Tan SC; Department of Medical Education, Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA., Iyer NR; Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Khan NH; Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Zechner EL; Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria., Fox JG; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Breinbauer R; Institute of Organic Chemistry, Graz University of Technology, 8010 Graz, Austria., Qi C; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Yamini B; Department of Surgery, Section of Neurosurgery, The University of Chicago, Chicago, IL 60637, USA., Ting JP; Department of Genetics, Department of Microbiology-Immunology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., De Plaen IG; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Karst SM; Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Tan XD; Pediatric Mucosal Inflammation and Regeneration Research Program, Center for Pediatric Translational Research and Education, Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Research & Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA. Electronic address: xtan25@uic.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 Oct 09; Vol. 32 (10), pp. 1805-1821.e10. Date of Electronic Publication: 2024 Sep 17.

Feeding cessation and antibiotics improve clinical symptoms and alleviate gut and systemic inflammation in preterm pigs sensitive to necrotizing enterocolitis.

Autor: Wu Z; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark., Bæk O; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark., Muk T; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark., Yang L; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark., Shen RL; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark., Gangadharan B; Plasma-derived therapies, Baxalta Innovations GmbH, Austria, part of Takeda Pharmaceuticals Ltd., Bilic I; Plasma-derived therapies, Baxalta Innovations GmbH, Austria, part of Takeda Pharmaceuticals Ltd., Nielsen DS; Department of Food Science, University of Copenhagen, Denmark., Sangild PT; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen Ø DK-2100, Denmark; Department of Paediatrics, Odense University Hospital, Odense C DK-5000, Denmark., Nguyen DN; Section for Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark. Electronic address: dnn@sund.ku.dk.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Oct; Vol. 179, pp. 117391. Date of Electronic Publication: 2024 Sep 05.

Git2 deficiency promotes MDSCs recruitment in intestine via NF-κB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis.

Autor: Le H; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China., Wang Y; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China., Zhou J; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China., Li D; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China., Gong Z; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China., Zhu F; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China., Wang J; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China., Tian C; State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. Electronic address: tianchunyan@ncpsb.org.cn., Cai W; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China. Electronic address: caiw204@sjtu.edu.cn., Wu J; Department of pediatric Surgery, Xinhua hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China. Electronic address: wujin@xinhuamed.com.cn.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2024 Oct; Vol. 17 (5), pp. 1060-1071. Date of Electronic Publication: 2024 Jul 27.