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Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma
Autor:
Afshan Begum, A.E. Sauer-Eriksson, Irina Iakovleva, Lina Nilsson, Annelie Olofsson, Kristoffer Brännström, Intissar Anan, Anna L. Gharibyan, M Walfridsson
Publikováno v:
Journal of Medicinal Chemistry. 58:6507-6515
The plasma protein transthyretin (TTR) is linked to human amyloidosis. Dissociation of its native tetrameric assembly is a rate-limiting step in the conversion from a native structure into a pathological amyloidogenic fold. Binding of small molecule
Autor:
Sjur D. Flåm, Sverre Storøy
Publikováno v:
Modeling, Identification and Control, Vol 7, Iss 2, Pp 83-92 (1986)
This paper is concerned with the allocation of exploratory efforts under the limitation of a fixed budget. A chance constrained problem is formulated. To solve this problem an algorithm is developed which is based on the entropic penalty approach rec
Externí odkaz:
https://doaj.org/article/d8f6ea40a1bb4272921b8ffb275f601b
Autor:
Sverre Storøy, Sjur Didrik Flåm
Publikováno v:
Modeling, Identification and Control, Vol 7, Iss 2, Pp 83-92 (1986)
This paper is concerned with the allocation of exploratory efforts under the limitation of a fixed budget. A chance constrained problem is formulated. To solve this problem an algorithm is developed which is based on the entropic penalty approach rec