Zobrazeno 1 - 10
of 389
pro vyhledávání: '"enhancer RNA"'
Autor:
E. M. Stasevich, A. V. Simonova, A. N. Uvarova, E. A. Zheremyan, K. V. Korneev, E. A. Bogomolova, D. E. Demin
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 813-816 (2024)
The transcription factor STAT3 serves as an immunoregulator by playing a crucial role in cytokine receptor signaling. However, in various cancer cell types, STAT3 is involved in the molecular mechanisms of oncogenesis. Specifically, in glioblastoma,
Externí odkaz:
https://doaj.org/article/adf7e29577084602ada70b5e4be14a26
Autor:
Yi-Min Cai, Ze-Qun Lu, Bin Li, Jin-Yu Huang, Ming Zhang, Can Chen, Lin-Yun Fan, Qian-Ying Ma, Chun-Yi He, Shuo-Ni Chen, Yuan Jiang, Yan-Min Li, Cai-Bo Ning, Fu-Wei Zhang, Wen-Zhuo Wang, Yi-Zhuo Liu, Heng Zhang, Meng Jin, Xiao-Yang Wang, Jin-Xin Han, Zhen Xiong, Ming Cai, Chao-Qun Huang, Xiao-Jun Yang, Xu Zhu, Ying Zhu, Xiao-Ping Miao, Shao-Kai Zhang, Yong-Chang Wei, Jian-Bo Tian
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-24 (2024)
Abstract Background Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic basis of eRNA expres
Externí odkaz:
https://doaj.org/article/27381517e57f4c8cbe32281a2abf9fc7
Publikováno v:
eLife, Vol 13 (2024)
The nuclear receptor, farnesoid X receptor (FXR/NR1H4), is increasingly recognized as a promising drug target for metabolic diseases, including nonalcoholic steatohepatitis (NASH). Protein-coding genes regulated by FXR are well known, but whether FXR
Externí odkaz:
https://doaj.org/article/571e1decb87e448093a25b0c09ec732a
Autor:
Harindra E. Amarasinghe, Ping Zhang, Justin P. Whalley, Alice Allcock, Gabriele Migliorini, Andrew C. Brown, Giuseppe Scozzafava, Julian C. Knight
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-19 (2023)
Abstract Background Monocytes are key mediators of innate immunity to infection, undergoing profound and dynamic changes in epigenetic state and immune function which are broadly protective but may be dysregulated in disease. Here, we aimed to advanc
Externí odkaz:
https://doaj.org/article/5ab61c5126b04d9f9db2e20d3b2d1e7a
Autor:
Anh Phuong Nguyen, Kaoru Yamagata, Shigeru Iwata, Gulzhan Trimova, Tong Zhang, Yu Shan, Mai-Phuong Nguyen, Koshiro Sonomoto, Shingo Nakayamada, Shigeaki Kato, Yoshiya Tanaka
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-12 (2022)
Abstract Background Highly regulated gene expression program underlies osteogenesis of mesenchymal stem cells (MSCs), but the regulators in the program are not entirely identified. As enhancer RNAs (eRNAs) have recently emerged as a key regulator in
Externí odkaz:
https://doaj.org/article/87e136a6e6e8424cb06551879fb010b0
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 226-244 (2022)
Hepatocellular carcinoma (HCC) is highly heterogeneous. Molecular subtyping for guiding immunotherapy is warranted. Previous studies have indicated that enhancer RNAs (eRNAs) are involved in tumor heterogeneity and immune infiltration. However, the e
Externí odkaz:
https://doaj.org/article/58d8bcbc135e46909aa6cb8ef9553cd6
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 534 (2023)
Significant advances have been achieved in understanding the critical role of enhancer RNAs (eRNAs) in the complex field of gene regulation. However, notable uncertainty remains concerning the biology of eRNAs, highlighting the need for continued res
Externí odkaz:
https://doaj.org/article/bb64c37349804ad9948d70d7404cb757
Publikováno v:
BMC Genomics, Vol 22, Iss S3, Pp 1-8 (2021)
Abstract Background A new class of regulatory elements called super-enhancers, comprised of multiple neighboring enhancers, have recently been reported to be the key transcriptional drivers of cellular, developmental, and disease states. Results Here
Externí odkaz:
https://doaj.org/article/984823a71155488da684c57a2649353d
Akademický článek
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Autor:
Jinhui Liu, Jian Yin, Yuanyuan Wang, Lixin Cai, Rui Geng, Mulong Du, Zihang Zhong, Senmiao Ni, Xiaohao Huang, Hao Yu, Jianling Bai
Publikováno v:
Biological Procedures Online, Vol 24, Iss 1, Pp 1-17 (2022)
Abstract Background Long non-coding RNAs (lncRNA) have been implicated in a hand of studies that supported an involvement and co-operation in Uterine Corpus Endometrial Carcinoma (UCEC). Enhancer RNAs (eRNA), a functional subtype of lncRNA, have a ke
Externí odkaz:
https://doaj.org/article/96c84e700b79450886438cc64bb75e1b