Zobrazeno 1 - 10
of 464
pro vyhledávání: '"endolysosome"'
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 3, Pp 671-681 (2025)
Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprog
Externí odkaz:
https://doaj.org/article/66df2eef90b044c5b913ad03580726c1
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 4, Pp 1383-1399 (2023)
Exosome is an excellent vesicle for in vivo delivery of therapeutics, including RNAi and chemical drugs. The extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without
Externí odkaz:
https://doaj.org/article/b08dc3dfc06f426996e2c2b54d7aa1a6
Autor:
Sara A. Lewis, Somayeh Bakhtiari, Jacob Forstrom, Allan Bayat, Frédéric Bilan, Gwenaël Le Guyader, Ebba Alkhunaizi, Hilary Vernon, Sergio R. Padilla-Lopez, Michael C. Kruer
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/b5bc83387ee645bd900fb0386a2ee975
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Amino acid transporters are generally recognized as machinery that transport amino acids from the extracellular environment into the cytoplasm. Although their primary function is the uptake of amino acids to supply the cell with nutrients and energy,
Externí odkaz:
https://doaj.org/article/2af25208b06741bbbaa9c691377f8ef3
Autor:
Tadayuki Komori, Tomoki Kuwahara
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1645 (2023)
Over the last decades, research on the pathobiology of neurodegenerative diseases has greatly evolved, revealing potential targets and mechanisms linked to their pathogenesis. Parkinson’s disease (PD) is no exception, and recent studies point to th
Externí odkaz:
https://doaj.org/article/0ece8b09ffe548ac9d162fb91453c4c3
Autor:
Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johannes V. Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas this may initiate disease in familial cases, onset in sporadic diseases may originate from a gradually disrupted organellar homeostasis. Herein, endolysosomal abnor
Externí odkaz:
https://doaj.org/article/71b18339eb854ed494b75e0a5a5c3764
Autor:
Nobumasa Takasugi, Masato Komai, Nanaka Kaneshiro, Atsuya Ikeda, Yuji Kamikubo, Takashi Uehara
Publikováno v:
Cells, Vol 12, Iss 3, p 454 (2023)
Aducanumab, co-developed by Eisai (Japan) and Biogen (U.S.), has received Food and Drug Administration approval for treating Alzheimer’s disease (AD). In addition, its successor antibody, lecanemab, has been approved. These antibodies target the ag
Externí odkaz:
https://doaj.org/article/49bd45343bc04324a3273f88ddec50c2
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresis
Externí odkaz:
https://doaj.org/article/4fcfbab708a1463080b9fa9de92b3e9e