Zobrazeno 1 - 10
of 38
pro vyhledávání: '"endochin-like quinolones"'
Autor:
Julia Senkina, Spencer Knapp
Publikováno v:
Molecules, Vol 29, Iss 15, p 3615 (2024)
In order to improve the drug-likeness qualities, the antimalarial endochin-like quinolone (ELQ) scaffold has been modified by replacing the 4-(trifluoromethoxy)phenyl portion with an isoidide unit that is further adjustable by varying the distal O-su
Externí odkaz:
https://doaj.org/article/00edeaaf174f47b69c73daba9889d46e
Autor:
Nicoleta Anghel, Dennis Imhof, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Haenggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 92-106 (2021)
The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes
Externí odkaz:
https://doaj.org/article/d2ab6fc7c7674245a649097532f71673
Akademický článek
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Akademický článek
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Autor:
Naja Eberhard, Vreni Balmer, Joachim Müller, Norbert Müller, Rolf Winter, Soviti Pou, Aaron Nilsen, Mike Riscoe, Samuel Francisco, Alexandre Leitao, J. Stone Doggett, Andrew Hemphill
Publikováno v:
Frontiers in Veterinary Science, Vol 7 (2020)
Endochin-like quinolones (ELQs) potently inhibit the proliferation of Plasmodium, Toxoplasma, Neospora, and Babesia by targeting the cytochrome b Qo and Qi sites and interfering with oxidative phosphorylation and pyrimidine biosynthesis. The activiti
Externí odkaz:
https://doaj.org/article/3018e9a1963f4eb2a00b256113e60aed
Publikováno v:
Molecules, Vol 25, Iss 7, p 1574 (2020)
Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, whic
Externí odkaz:
https://doaj.org/article/3613642590084575ab462cd726034b05
Autor:
Nicoleta Anghel, Vreni Balmer, Joachim Müller, Pablo Winzer, Adriana Aguado-Martinez, Mona Roozbehani, Sovitj Pou, Aaron Nilsen, Michael Riscoe, J. Stone Doggett, Andrew Hemphill
Publikováno v:
Frontiers in Veterinary Science, Vol 5 (2018)
We report on the efficacy of selected endochin-like quinolones (ELQs) against N. caninum tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic N. caninum tachyzoite
Externí odkaz:
https://doaj.org/article/e77756f34e184cd3b80487fcf8046c1a
Autor:
Dennis Imhof, Jessica Ramseier, Wesley C. Van Voorhis, Andrew Hemphill, Samuel L.M. Arnold, Grant R. Whitman, Vreni Balmer, J. Stone Doggett, Matthew A. Hulverson, Ryan Choi, Kayode K. Ojo, Pablo Winzer, Luis Miguel Ortega-Mora, Kai Haenggeli, Nicoleta Anghel
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 92-106 (2021)
Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007
International Journal for Parasitology: Drugs and Drug Resistance
Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007
International Journal for Parasitology: Drugs and Drug Resistance
The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47feace5d35bf82430013b60b579c9e
http://www.sciencedirect.com/science/article/pii/S2211320721000439
http://www.sciencedirect.com/science/article/pii/S2211320721000439
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Molecules
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
MOLECULES
Molecules, Vol 25, Iss 1574, p 1574 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
MOLECULES
Molecules, Vol 25, Iss 1574, p 1574 (2020)
Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab770338d251a6972d79af60c95bd688
https://pubmed.ncbi.nlm.nih.gov/32235463
https://pubmed.ncbi.nlm.nih.gov/32235463