Zobrazeno 1 - 10
of 317
pro vyhledávání: '"endoMT"'
Autor:
Van-Cuong Pham, Claudia Jasmin Rödel, Mariaelena Valentino, Matteo Malinverno, Alessio Paolini, Juliane Münch, Candice Pasquier, Favour C Onyeogaziri, Bojana Lazovic, Romuald Girard, Janne Koskimäki, Melina Hußmann, Benjamin Keith, Daniel Jachimowicz, Franziska Kohl, Astrid Hagelkruys, Josef M Penninger, Stefan Schulte-Merker, Issam A Awad, Ryan Hicks, Peetra U Magnusson, Eva Faurobert, Massimiliano Pagani, Salim Abdelilah-Seyfried
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2827-2855 (2024)
Abstract Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological p
Externí odkaz:
https://doaj.org/article/a3e67a3c4c2b45fb843c16dfd7fbb6eb
Autor:
Shuai Guo, Yi Dong, Ran Du, Yu-Xing Liu, Shu Liu, Qin Wang, Ji-Shi Liu, Hui Xu, Yu-Jie Jiang, Huang Hao, Liang-Liang Fan, Rong Xiang
Publikováno v:
Molecular Biomedicine, Vol 5, Iss 1, Pp 1-17 (2024)
Abstract Chronic kidney disease (CKD) poses a significant global health dilemma, emerging from complex causes. Although our prior research has indicated that a deficiency in Reticulon-3 (RTN3) accelerates renal disease progression, a thorough examina
Externí odkaz:
https://doaj.org/article/b1214927b9f14e828954359a36c32f71
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)
Background The metabolic flexibility of endothelial cells is linked to their phenotypic plasticity. Frataxin is critical in determining the iron metabolism and fate of endothelial cells. This study aimed to investigate frataxin‐mediated metabolic r
Externí odkaz:
https://doaj.org/article/e2a5f5ea1bf045168679216ba57b3459
Autor:
Zeli Yin, Liming Wang
Publikováno v:
Annals of Medicine, Vol 55, Iss 1, Pp 1058-1069 (2023)
AbstractTumour-associated endothelial cells (TECs) are a critical stromal cell type in the tumour microenvironment and play central roles in tumour angiogenesis. Notably, TECs have phenotypic plasticity, as they have the potential to transdifferentia
Externí odkaz:
https://doaj.org/article/e9aa2ac6a6c64368a587bd1601cac218
Autor:
Wakako Daido, Taku Nakashima, Takeshi Masuda, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Nestin, an intermediate filament protein, participates in various pathophysiological processes, including wound healing, angiogenesis, endothelial–mesenchymal transition (EndoMT), and fibrosis. However, the pathophysiological ro
Externí odkaz:
https://doaj.org/article/6720eee729c94fe0a0fd10d2e2219553
Publikováno v:
Journal of Integrative Neuroscience, Vol 23, Iss 7, p 124 (2024)
Objectives: Endothelial-to-mesenchymal transition (EndoMT) is a significant biological phenomenon wherein endothelial cells undergo a loss of their endothelial traits and progressively acquire mesenchymal characteristics. Consequently, this transform
Externí odkaz:
https://doaj.org/article/c7764d4a83fb4d658fa0d75218048565
Autor:
Frontiers Production Office
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/5551a24306fd471391334ab20ad40b9f
Autor:
Chak Kwong Cheng, Xiao Lin, Yujie Pu, Joyce Ka Yu Tse, Yu Wang, Cheng-Lin Zhang, Xiaoyun Cao, Chi Wai Lau, Juan Huang, Lei He, Jiang-Yun Luo, Yu-Tsung Shih, Song Wan, Chi Fai Ng, Li Wang, Ronald Ching Wan Ma, Jeng-Jiann Chiu, Ting Fung Chan, Xiao Yu Tian, Yu Huang
Publikováno v:
Journal of Advanced Research, Vol 43, Iss , Pp 187-203 (2023)
Introduction: Atherosclerotic complications represent the leading cause of cardiovascular mortality globally. Dysfunction of endothelial cells (ECs) often initiates the pathological events in atherosclerosis. Objectives: In this study, we sought to i
Externí odkaz:
https://doaj.org/article/e144a2f5dcd048b6b13f752db314834f
Autor:
Paul-Lennard Mendez, Leon Obendorf, Jerome Jatzlau, Wiktor Burdzinski, Maria Reichenbach, Vanasa Nageswaran, Arash Haghikia, Verena Stangl, Christian Hiepen, Petra Knaus
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial quiescence, excessive
Externí odkaz:
https://doaj.org/article/f21e33dc96904caabcbae15c6de679ca
Autor:
Priyanka Banerjee, Julia Enterría Rosales, Khanh Chau, Minh T. H. Nguyen, Sivareddy Kotla, Steven H. Lin, Anita Deswal, Robert Dantzer, Elizabeth A. Olmsted-Davis, Hung Nguyen, Guangyu Wang, John P. Cooke, Jun-ichi Abe, Nhat-Tu Le
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Cancer survivors undergone treatment face an increased risk of developing atherosclerotic cardiovascular disease (CVD), yet the underlying mechanisms remain elusive. Recent studies have revealed that chemotherapy can drive senescent cancer cells to a
Externí odkaz:
https://doaj.org/article/cec1f71c867b45be903698f6ffeae7b5