Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity

Autor: M.J.V. Brandt, C.M. Kosmeijer, E.J.M. Achterberg, C.G.M. de Theije, C.H. Nijboer

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 40, Iss , Pp 100817- (2024)

Extreme preterm birth-associated adversities are a major risk factor for aberrant brain development, known as encephalopathy of prematurity (EoP), which can lead to long-term neurodevelopmental impairments. Although progress in clinical care for pret

Externí odkaz: https://doaj.org/article/5ca1997cb25f4f22b926b1fdd941fac0

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Melatonin as a Therapy for Preterm Brain Injury: What Is the Evidence?

Autor: Silke Häusler, Nicola J. Robertson, Klervi Golhen, John van den Anker, Katie Tucker, Thomas K. Felder

Publikováno v: Antioxidants, Vol 12, Iss 8, p 1630 (2023)

Despite significant improvements in survival following preterm birth in recent years, the neurodevelopmental burden of prematurity, with its long-term cognitive and behavioral consequences, remains a significant challenge in neonatology. Neuroprotect

Externí odkaz: https://doaj.org/article/b2fbbe7ebfd8478da6ae70917c39a3e0

Cumulative Damage: Cell Death in Posthemorrhagic Hydrocephalus of Prematurity

Autor: Riley Sevensky, Jessie C. Newville, Ho Lam Tang, Shenandoah Robinson, Lauren L. Jantzie

Publikováno v: Cells, Vol 10, Iss 8, p 1911 (2021)

Globally, approximately 11% of all infants are born preterm, prior to 37 weeks’ gestation. In these high-risk neonates, encephalopathy of prematurity (EoP) is a major cause of both morbidity and mortality, especially for neonates who are born very

Externí odkaz: https://doaj.org/article/7bb04d0bcbd74b32a1ed29beee9463a8

Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders

Autor: Eleanor L.S. Conole, Kadi Vaher, Manuel Blesa Cabez, Gemma Sullivan, Anna J. Stevenson, Jill Hall, Lee Murphy, Michael J. Thrippleton, Alan J. Quigley, Mark E. Bastin, Veronique E. Miron, Heather C. Whalley, Riccardo E. Marioni, James P. Boardman, Simon R. Cox

Publikováno v: Conole, E L S, Vaher, K, Cabez, M B, Sullivan, G, Stevenson, A J, Hall, J, Murphy, L, Thrippleton, M J, Quigley, A J, Bastin, M E, Miron, V E, Whalley, H C, Marioni, R E, Boardman, J P & Cox, S R 2023, ' Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders ', Brain, Behavior, and Immunity, vol. 110, pp. 322-338 . https://doi.org/10.1016/j.bbi.2023.03.011

BackgroundPreterm birth is closely associated with a phenotype that includes brain dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of Prematurity (EoP), of which systemic inflammation is considered a key driver. DNA methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89fe18d65c60f9801dcfa7971c27168
https://hdl.handle.net/20.500.11820/25aee2b8-6c8d-4d9d-af35-8c0e8435f411