Zobrazeno 1 - 10
of 255
pro vyhledávání: '"emt (epithelial to mesenchymal transition)"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The tumor microenvironment (TME) is the source of important cues that govern epithelial-to-mesenchymal transition (EMT) and facilitate the acquisition of aggressive traits by cancer cells. It is now recognized that EMT is not a binary program, and ca
Externí odkaz:
https://doaj.org/article/927dd107d2f74d339f0ad6822669b856
Autor:
Yi Shou, Yuenan Liu, Jiaju Xu, Jingchong Liu, Tianbo Xu, Junwei Tong, Lilong Liu, Yaxin Hou, Di Liu, Hongmei Yang, Gong Cheng, Xiaoping Zhang
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Renal cell carcinoma (RCC) is one of the most common malignancies in the urinary system. The mortality of advanced RCC remains high despite advances in systemic therapy of RCC. Considering the misdiagnosis of early-stage RCC, the identification of ef
Externí odkaz:
https://doaj.org/article/041c431033bb48ffb5bb80aa425bc492
Autor:
Esther Dronkers, Tessa van Herwaarden, Thomas J van Brakel, Gonzalo Sanchez-Duffhues, Marie-José Goumans, Anke M Smits
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The epicardium, the mesothelial layer covering the heart, is a crucial cell source for cardiac development and repair. It provides cells and biochemical signals to the heart to facilitate vascularization and myocardial growth. An essential element of
Externí odkaz:
https://doaj.org/article/806a16335a1a4e74b0686f399d3fb8b4
Autor:
Christina H. Stuelten, Ying E. Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early stage tumorigenesis and promotes late stage tumor progression and metast
Externí odkaz:
https://doaj.org/article/17b52cfd64d64ea6bfedf4a60b382fd4
Autor:
Eva Martinez-Balibrea, Yari Ciribilli
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/fa701cf929c34a40ab57044053621213
Autor:
Cecilia Battistelli, Marco Cordani, Marc Diederich, Álvaro Somoza, Sergio Valente, Raffaele Strippoli
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/b4718eaef3ed4f648fd2d6142d050e3d
Publikováno v:
Cell Adhesion & Migration, Vol 13, Iss 1, Pp 203-218 (2019)
EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain of Notch3 (N3ICD) can inhibit EMT in breast cancer cells. In this study, we a
Externí odkaz:
https://doaj.org/article/8a31b4d9a4104ad7b146da6704fefa15
Autor:
Salem Chouaib, James Lorens
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/b5b9aa469ac7425d885362c848ca73b7
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Fibrosis is considered a complex form of tissue damage commonly present in the end stage of many diseases. It is also related to a high percentage of death, whose predominant characteristics are an excessive and abnormal deposition of fibroblasts and
Externí odkaz:
https://doaj.org/article/8bbebe1975b441959ac8106db582530e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Externí odkaz:
https://doaj.org/article/150e35241d6a4464be7e559790c1cedd