Zobrazeno 1 - 10
of 3 463
pro vyhledávání: '"embryonic lethality"'
Autor:
Ou Jian, Ni MengXia, Xing Shiyu, Meng QingXia, Zou QinYan, Ding Jie, Wang Wei, Wan Jiaojiao, Li Hong, Huang Yining
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Background Preimplantation embryonic lethality is a driver of female infertility. Certain microRNAs (miRNAs) have previously been demonstrated to play important roles in the regulation of embryogenesis. Methods Normally developing blastocyst
Externí odkaz:
https://doaj.org/article/75f9912cd0014ac689abec1b0391939d
Autor:
Nickolas Auclair, Alain T. Sané, Léna Ahmarani, Nour-El-Houda Ould-Chikh, Nathalie Patey, Jean-François Beaulieu, Edgard Delvin, Schohraya Spahis, Emile Levy
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 9, Pp 100423- (2023)
Biallelic pathogenic variants of the Sar1b gene cause chylomicron retention disease (CRD) whose central phenotype is the inability to secrete chylomicrons. Patients with CRD experience numerous clinical symptoms such as gastrointestinal, hepatic, neu
Externí odkaz:
https://doaj.org/article/fac6eb6ad59e469280811c93cc3f46d2
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Sorting nexin 17 (SNX17), a member of sorting nexin (SNX) family, acts as a modulator for endocytic recycling of membrane proteins. Results from our previous study demonstrated the embryonic lethality of homozygous defect of SNX17. In this study, we
Externí odkaz:
https://doaj.org/article/807d6f369efa4d01a42ffe4a53ca60cf
Autor:
Hyae Yon Kweon, Mi-Ni Lee, Max Dorfel, Seungwoon Seo, Leah Gottlieb, Thomas PaPazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael Flory, Jonathan Crain, Alison Sebold, Scott Lyons, Ahmed Ismail, Elaine Marchi, Seong-keun Sonn, Se-Jin Jeong, Sejin Jeon, Shinyeong Ju, Simon J Conway, Taesoo Kim, Hyun-Seok Kim, Cheolju Lee, Tae-Young Roh, Thomas Arnesen, Ronen Marmorstein, Goo Taeg Oh, Gholson J Lyon
Publikováno v:
eLife, Vol 10 (2021)
Amino-terminal acetylation is catalyzed by a set of N-terminal acetyltransferases (NATs). The NatA complex (including X-linked Naa10 and Naa15) is the major acetyltransferase, with 40–50% of all mammalian proteins being potential substrates. Howeve
Externí odkaz:
https://doaj.org/article/d85446a69857408ca85b40a4aca5a127
Autor:
Manyu Zhang, Chunyu Liu, Beili Chen, Mingrong Lv, Huijuan Zou, Yajing Liu, Yang Gao, Tianjuan Wang, Qiong Xing, Yutong Zhu, Huan Wu, Zhiguo Zhang, Ping Zhou, Zhaolian Wei, Xiaojin He, Yuping Xu, Yunxia Cao
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Preimplantation embryonic lethality is a rare cause of primary female infertility. It has been reported that variants in the transducin-like enhancer of split 6 (TLE6) gene can lead to preimplantation embryonic lethality. However, the incidence of TL
Externí odkaz:
https://doaj.org/article/07edb7781138433dbcbe967594f08d62
Autor:
Tra Thi Huong Dinh, Hiroyoshi Iseki, Seiya Mizuno, Saori Iijima-Mizuno, Yoko Tanimoto, Yoko Daitoku, Kanako Kato, Yuko Hamada, Ammar Shaker Hamed Hasan, Hayate Suzuki, Kazuya Murata, Masafumi Muratani, Masatsugu Ema, Jun-Dal Kim, Junji Ishida, Akiyoshi Fukamizu, Mitsuyasu Kato, Satoru Takahashi, Ken-ichi Yagami, Valerie Wilson, Ruth M Arkell, Fumihiro Sugiyama
Publikováno v:
eLife, Vol 10 (2021)
In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the
Externí odkaz:
https://doaj.org/article/47b0afb571434225ae530bc466486e2e
Autor:
Kit-Yi Leung, Sandra C. P. De Castro, Gabriel L. Galea, Andrew J. Copp, Nicholas D. E. Greene
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine. Mutation of AMT or GLDC, encoding the GCS components aminomethyltransferase and glycine deca
Externí odkaz:
https://doaj.org/article/37c5049f4a084bb58c2472ba1b4ac0ed