Zobrazeno 1 - 10
of 1 548
pro vyhledávání: '"efficacy and safety"'
Autor:
I. S. Giba
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 5, Pp 601-611 (2024)
INTRODUCTION. Bioanalytical laboratories in the Russian Federation should follow the requirements of both the Good Laboratory Practices (GLP), when performing tests for non-clinical studies, and the Good Clinical Practices (GCP), when analysing sampl
Externí odkaz:
https://doaj.org/article/35539eedc5eb4b2cbe58378232959e4b
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract This study aimed to assess the effectiveness and safety of 5-Fluorouracil (5-Fu) combined with conventional transarterial chemoembolization (cTACE) compared to 5-Fu combined with drug-eluting bead transarterial chemoembolization (DEB-TACE) u
Externí odkaz:
https://doaj.org/article/ac26f7ca3aac432990dd49d8ba62e129
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background As we delve into the intricate world of venetoclax combination therapy in relapsed or refractory acute myeloid leukemia (AML), our exploration not only aims to contribute to the current body of knowledge but also strives to inform
Externí odkaz:
https://doaj.org/article/c45798f47326429a914cb9f7c8578e0b
Autor:
Hidehisa Saeki, Yukihiro Ohya, Naoko Baba, Tomomi Imamura, Daisuke Yokota, Hidetsugu Tsubouchi
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 9, Pp 2443-2455 (2024)
Abstract Introduction Difamilast is the first selective phosphodiesterase 4 inhibitor approved for atopic dermatitis (AD) in Japan. A phase 3, 52-week, open-label study is ongoing to establish efficacy and safety of difamilast ointments in infants wi
Externí odkaz:
https://doaj.org/article/c94391492d88432cafa603d838b6e229
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundUpadacitinib, a specific JAK1 inhibitor, has minimal effect on other JAK subtypes. It influences the inflammatory process in various ways. Upadacitinib has been approved for conditions such as rheumatoid arthritis, psoriatic arthritis, atop
Externí odkaz:
https://doaj.org/article/6f7e76b379f7420ca88975edd1083672
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
In clinical practice, some cases of chronic spontaneous urticaria (CSU) remain difficult to treat, with up to 40% of patients showing no response to even high (4-fold) daily doses of antihistamines. Approximately 30% of CSU patients fail to achieve c
Externí odkaz:
https://doaj.org/article/c45119f8cfb74140886a5ecbd3f8d2be
Autor:
Kaiqi Chen, Xinwei Wang, Rui Yue, Wei Chen, Danping Zhu, Shikui Cui, Xijian Zhang, Zhao Jin, Tong Xiao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundRandomized controlled trials (RCTs) have unequivocally established the therapeutic advantages of combining immune checkpoint inhibitors (ICIs) with chemotherapy in the treatment of early-stage non-small cell lung cancer (NSCLC). Presently,
Externí odkaz:
https://doaj.org/article/ddfe2efd6f7841f8af64ce6e7c14b66b
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundA multitude of randomized controlled trials (RCTs) conducted in both the initial and subsequent treatment settings for patients diagnosed with metastatic colorectal cancer (mCRC) have provided clinical evidence supporting the efficacy of im
Externí odkaz:
https://doaj.org/article/32d9572d1282432886e1700585c8d47e
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background There are a few studies on the effectiveness and safety of intravenous administration of tranexamic acid(TXA) in patients who underwent foot and ankle surgery, especially for preoperative hidden blood loss in patients with freshfo
Externí odkaz:
https://doaj.org/article/04a08c4669134c8f8a77b869efece8f2
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 4, Pp 659-666 (2024)
Abstract Seasonal influenza is usually considered an acute respiratory infection with a full recovery within a week. In addition to the traditional outcomes, there is now evidence of indirect effects in terms of neurological and functional complicati
Externí odkaz:
https://doaj.org/article/6b83ed0e223d49ff95a8c57142c44ea4