DSP-0509, a systemically available TLR7 agonist, exhibits combination effect with immune checkpoint blockade by activating anti-tumor immune effects

Autor: Yosuke Ota, Yasuhiro Nagai, Yuko Hirose, Seiji Hori, Erina Koga-Yamakawa, Ken Eguchi, Kentaro Sumida, Masashi Murata, Hiroki Umehara, Setsuko Yamamoto

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

TLR7 is an innate immune receptor that recognizes single-stranded RNAs, and its activation leads to anti-tumor immune effects. Although it is the only approved TLR7 agonist in cancer therapy, imiquimod is allowed to be administered with topical formu

Externí odkaz: https://doaj.org/article/103bbd04cd954e7799b9a9439e8f176b

Cytotoxin-Associated Gene A-Negative Helicobacter pylori Promotes Gastric Mucosal CX3CR1+CD4+ Effector Memory T Cell Recruitment in Mice

Autor: Heqiang Sun, Taojun He, Yanan Wu, Hanmei Yuan, Jie Ning, Zhenhua Zhang, Xinli Deng, Bin Li, Chao Wu

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

BackgroundHelicobacter pylori can cause many kinds of gastric disorders, ranging from gastritis to gastric cancer. Cytotoxin-associated gene A (CagA)+H. pylori is more likely to cause gastric histopathologic damage than CagA–H. pylori. However, the

Externí odkaz: https://doaj.org/article/717ba2e785f244d9afda90da1045405e

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Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium

Autor: Andrew R. Medvec, Christopher Ecker, Hong Kong, Emily A. Winters, Joshua Glover, Angel Varela-Rohena, James L. Riley

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 65-74 (2018)

Improvements to T cell culture systems that promote long-term engraftment and function of adoptively transferred T cells will likely result in superior clinical benefit to more individuals. To this end, we recently developed a chemically defined cell

Externí odkaz: https://doaj.org/article/4b72adeeb7ef495f864b298b3073f32a

Norovirus-Specific CD8+ T Cell Responses in Human Blood and Tissues

Autor: Ralph S. Baric, Michael R. Betts, Olesya Palko, Chi Wai Lau, Ajinkya Pattekar, Ali Naji, Lisa C. Lindesmith, Lena S. Mayer, Paul D. Brewer-Jensen, Chengyang Liu, Meenakshi Bewtra, E. John Wherry, Vesselin T. Tomov

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1267-1289 (2021)

Background & Aims Noroviruses (NoVs) are the leading cause of acute gastroenteritis worldwide and are associated with significant morbidity and mortality. Moreover, an asymptomatic carrier state can persist following acute infection, promoting NoV sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e0b504252133cddc455e553314399c
https://doi.org/10.1016/j.jcmgh.2020.12.012