Zobrazeno 1 - 3
of 3
pro vyhledávání: '"effector membrane translocation assay"'
Autor:
Charlotte Avet, Arturo Mancini, Billy Breton, Christian Le Gouill, Alexander S Hauser, Claire Normand, Hiroyuki Kobayashi, Florence Gross, Mireille Hogue, Viktoriya Lukasheva, Stéphane St-Onge, Marilyn Carrier, Madeleine Héroux, Sandra Morissette, Eric B Fauman, Jean-Philippe Fortin, Stephan Schann, Xavier Leroy, David E Gloriam, Michel Bouvier
Publikováno v:
eLife, Vol 11 (2022)
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are a
Externí odkaz:
https://doaj.org/article/34e18aa1566b4e768be5932a0e81dff7
Autor:
Madeleine Héroux, Hiroyuki Kobayashi, Christian Le Gouill, Arturo Mancini, Stephan Schann, Alexander S. Hauser, Stéphane St-Onge, Florence Gross, Marilyn Carrier, David E. Gloriam, Billy Breton, Sandra Morissette, Charlotte Avet, Viktoriya Lukasheva, Michel Bouvier, Claire Normand, Jean-Philippe Fortin, Eric B. Fauman, Mireille Hogue, Xavier Leroy
Publikováno v:
Avet, C, Mancini, A, Breton, B, Le Gouill, C, Hauser, A S, Normand, C, Kobayashi, H, Gross, F, Hogue, M, Lukasheva, V, St-Onge, S, Carrier, M, Héroux, M, Morissette, S, Fauman, E B, Fortin, J P, Schann, S, Leroy, X, Gloriam, D E & Bouvier, M 2022, ' Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs ', eLife, vol. 11, e74101 . https://doi.org/10.7554/eLife.74101
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501df337f957ca6da7e698ba9197d354
https://curis.ku.dk/ws/files/305174048/elife_74101_v2.pdf
https://curis.ku.dk/ws/files/305174048/elife_74101_v2.pdf
Autor:
Avet C; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Mancini A; Domain Therapeutics North America, Montréal, Canada., Breton B; Domain Therapeutics North America, Montréal, Canada., Le Gouill C; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Normand C; Domain Therapeutics North America, Montréal, Canada., Kobayashi H; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Gross F; Domain Therapeutics North America, Montréal, Canada., Hogue M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Lukasheva V; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., St-Onge S; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Carrier M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Héroux M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Morissette S; Domain Therapeutics North America, Montréal, Canada., Fauman EB; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, United States., Fortin JP; Pfizer Global R&D, Cambridge, United States., Schann S; Domain Therapeutics, Illkirch-Strasbourg, France., Leroy X; Domain Therapeutics, Illkirch-Strasbourg, France., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Bouvier M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.
Publikováno v:
ELife [Elife] 2022 Mar 18; Vol. 11. Date of Electronic Publication: 2022 Mar 18.