Zobrazeno 1 - 10
of 2 680
pro vyhledávání: '"effector functions"'
Autor:
Mario Morales-Martínez, David Andón-García, Karla Aimee Patiño-Santiago, Jesús Miguel Parga-Ortega, Abrahan Hernández-Hernández, Guillermo Aquino-Jarquin, Genaro Patino-Lopez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract T-cell activation is central for the initiation of T cell mediated adaptive immune response and is the result of the close communication between the Antigen Presenting Cell (APC) and the T lymphocyte. Although T-cell activation is currently
Externí odkaz:
https://doaj.org/article/254207a5d9f64fc7885b63a1efdb92d4
Autor:
Anne T. Gelderloos, Marije K. Verheul, Irene Middelhof, Mary-Lène de Zeeuw-Brouwer, Robert S. van Binnendijk, Anne-Marie Buisman, Puck B. van Kasteren
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Previous research has shown that repeated COVID-19 mRNA vaccination leads to a marked increase of SARS-CoV-2 spike-specific serum antibodies of the IgG4 subclass, indicating far-reaching immunoglobulin class switching after booste
Externí odkaz:
https://doaj.org/article/050304379be549e89f0273602be00b10
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Development of novel therapeutic proteins and biosimilars requires a thorough understanding of the relationship between their structure and function. Particularly, how IgG glycosylation affects its effector functions is a point increasingly underscor
Externí odkaz:
https://doaj.org/article/6c057d7513b44d1cb450e73700405754
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
Most investigations on the immune cell-activating potency of IgA used purified total IgA and/or specific isolated cell populations. As IgA2 has been reported to be more pro-inflammatory than IgA1, we aimed to employ a fast and convenient whole blood-
Externí odkaz:
https://doaj.org/article/ea7ecab5b77041fcbb8b26abd052cc22
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 8, p 293 (2024)
The tumor microenvironment plays a critical role in modulating immune responses associated with tumorigenesis, tumor progression, and metastasis. Dendritic cells (DC) play a key role in preventing and progression of metastatic neoplasia by driving an
Externí odkaz:
https://doaj.org/article/6f37a40af90f4ebab087446edd670fc2
Publikováno v:
Advanced Science, Vol 11, Iss 13, Pp n/a-n/a (2024)
Abstract Cetuximab resistance is a significant challenge in cancer treatment, requiring the development of novel therapeutic strategies. In this study, a series of multivalent rhamnose (Rha)‐modified nanobody conjugates are synthesized and their an
Externí odkaz:
https://doaj.org/article/f696de7c862c4d1eb7edd35e0f8589f6
Autor:
Marina Tuyishime, Rachel L. Spreng, Brady Hueber, Junsuke Nohara, Derrick Goodman, Cliburn Chan, Richard Barfield, Whitney E. Beck, Shalini Jha, Stephanie Asdell, Kevin Wiehe, Max M. He, David Easterhoff, Haleigh E. Conley, Taylor Hoxie, Thaddeus Gurley, Caroline Jones, Nihar Deb Adhikary, Francois Villinger, Rasmi Thomas, Thomas N. Denny, Michael Anthony Moody, Georgia D. Tomaras, Justin Pollara, R. Keith Reeves, Guido Ferrari
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rhesus macaques (RMs) are a common pre-clinical model used to test HIV vaccine efficacy and passive immunization strategies. Yet, it remains unclear to what extent the Fc-Fc receptor (FcR) interactions impacting antiviral activities of antibodies in
Externí odkaz:
https://doaj.org/article/b7b3507768fa4c4a8fd48081695cfafd
Autor:
Ruixiao Du, Chaoqiang An, Xin Yao, Yiping Wang, Ge Wang, Fan Gao, Lianlian Bian, Yalin Hu, Siyuan Liu, Qiaohui Zhao, Qunying Mao, Zhenglun Liang
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTCoxsackievirus A16 (CA16), a main causative agent of hand, foot, and mouth disease (HFMD), has become a serious public health concern in the Asia-Pacific region. Here, we generated an anti-CA16 monoclonal antibody, DMA2017, derived from an ep
Externí odkaz:
https://doaj.org/article/ef1f3e3d564849af80c0ac76b8d2f283