Protein Biochemistry and Molecular Modeling of the Intra-Melanosomal Domain of Human Recombinant Tyrp2 Protein and OCA8-Related Mutant Variants

Autor: Monika B. Dolinska, Taariq Woods, Isabella Osuna, Yuri V. Sergeev

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1305
International Journal of Molecular Sciences, Vol 23, Iss 1305, p 1305 (2022)

Tyrosinase-related protein 2 (Tyrp2) is involved in the melanogenesis pathway, catalyzing the tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Recently, a new type of albinism was discovered with disease-causing mutatio

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