Zobrazeno 1 - 10
of 993
pro vyhledávání: '"ectonucleotidases"'
Autor:
V. P. Patrakeeva
Publikováno v:
Сибирский научный медицинский журнал, Vol 44, Iss 5, Pp 53-60 (2024)
A search and analysis of scientific articles presented in the databases PubMed, ScienceDirect, Elsevier, eLibrary for 2000–2024 was carried out. The selection criterion was the presence in the articles of information on the concentration of extrace
Externí odkaz:
https://doaj.org/article/79dbd2ce5bc544c1bc5db732150c9059
Autor:
Carla Fernanda Furtado Gardani, Fernando Mendonça Diz, Luísa Brandalise Dondé, Liliana Rockenbach, Stefan Laufer, Fernanda Bueno Morrone
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Purines and pyrimidines are signaling molecules in the tumor microenvironment that affect cancer immunity. The purinergic signaling pathways have been shown to play an important role in the development and progression of cancer. CD39 and CD73 are ect
Externí odkaz:
https://doaj.org/article/a212efaf8ba745b8ad62c31a4f892f44
Akademický článek
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Autor:
Ting Sun, Bin Liu, Yanyan Li, Jie Wu, Yufei Cao, Shuangyu Yang, Huiling Tan, Lize Cai, Shiqi Zhang, Xinyue Qi, Dingjia Yu, Wei Yang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-15 (2023)
Abstract Background Chimeric antigen receptor (CAR)-T immunotherapy fails to treat solid tumors due in part to immunosuppressive microenvironment. Excess lactate produced by tumor glycolysis increases CAR-T immunosuppression. The mechanism of lactate
Externí odkaz:
https://doaj.org/article/bd00b277fe70447d9026ba33af027f15
Autor:
Abdullah Yahya Abdullah Alzahrani, Abdul Hameed, Abdul Rehman Khan, Julie Pelletier, Jean Sévigny, Jamshed Iqbal
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101548- (2024)
Herein, we describe the design, synthesis and biological evaluation of a series of novel non-nucleotide sulfonylurea and sulfonylthiourea based small molecule inhibitors of h-ENPP1, h-ENPP3 and e5′NT. Among the tested compounds, 3b inhibited h-ENPP
Externí odkaz:
https://doaj.org/article/084f7a2ac98043509fae5bfc23da4fb5
Autor:
José Bernardo Noronha-Matos, Rui Pinto-Cardoso, Catarina Bessa-Andrês, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Maria Adelina Costa, José Marinhas, Rolando Freitas, Rui Lemos, Adélio Vilaça, António Oliveira, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Endogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells (BM-MSCs) through the activation of ATP-sensitive P2X7 and UDP-sensitive P2Y6 receptors. Yet, t
Externí odkaz:
https://doaj.org/article/95ea55a1f00f46fca819e6b29a679372
Autor:
Vitória Brum da Silva Nunes, Camila Kehl Dias, Juliete Nathali Scholl, Alexia Nedel Sant’Ana, Amanda de Fraga Dias, Mariela Granero Farias, Ana Paula Alegretti, Monalisa Sosnoski, Liane Esteves Daudt, Mariana Bohns Michalowski, Ana Maria Oliveira Battastini, Alessandra Aparecida Paz, Fabrício Figueiró
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Purpose Although risk-stratified chemotherapy regimens improve B-cell acute lymphoblastic leukemia (B-ALL) clinical outcome, relapse occurs in a significant number of cases. The identification of new therapeutic targets as well as prognostic
Externí odkaz:
https://doaj.org/article/3a581ca919d8488aa265a987c716ea9d
Autor:
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhélio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPlasmodium spp. infection triggers the production of inflammatory cytokines that are essential for parasite control, and conversely responsible for symptoms of malaria. Monocytes play a role in host defense against Plasmodium vivax infectio
Externí odkaz:
https://doaj.org/article/ed4f137f8034465b8ba22291bf0d4778
Akademický článek
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Publikováno v:
Медицинская иммунология, Vol 24, Iss 3, Pp 587-596 (2022)
Purinergic signaling modulates systemic and local inflammatory responses in immune-mediated and autoimmune diseases, including psoriasis. Extracellular ATP is an important factor of purinergic regulation, and its levels are regulated by catalytic eff
Externí odkaz:
https://doaj.org/article/e7e91f12253b4ecbb1f0fcca3c73f34b