Zobrazeno 1 - 10
of 874
pro vyhledávání: '"ectodomain shedding"'
Autor:
Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee, Karthikeyan Mythreye
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of
Externí odkaz:
https://doaj.org/article/ed54a9e793e64950bc11bf6731d8ff90
Autor:
Miguel Lobete, Tamel Salinas, Sara Izquierdo-Bermejo, Silvia Socas, María Jesús Oset-Gasque, M. Dolores Martín-de-Saavedra
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Ectodomain shedding (ES) is a fundamental process involving the proteolytic cleavage of membrane-bound proteins, leading to the release of soluble extracellular fragments (shed ectodomains) with potential paracrine and autocrine signaling functions.
Externí odkaz:
https://doaj.org/article/42b2f362fb9047e1b852c77441fb7b17
Autor:
Kevin C. Lahey, Christopher Varsanyi, Ziren Wang, Ahmed Aquib, Varsha Gadiyar, Alcina A. Rodrigues, Rachael Pulica, Samuel Desind, Viralkumar Davra, David C. Calianese, Dongfang Liu, Jong-Hyun Cho, Sergei V. Kotenko, Mariana S. De Lorenzo, Raymond B. Birge
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4404 (2024)
Mertk, a type I receptor tyrosine kinase and member of the TAM family of receptors, has important functions in promoting efferocytosis and resolving inflammation under physiological conditions. In recent years, Mertk has also been linked to pathophys
Externí odkaz:
https://doaj.org/article/58f6637deb6f481abb21a79db945bb96
Autor:
Chihiro Moriwaki, Riho Tanigaki, Yasunobu Miyake, Nghia Trong Vo, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Truong Nhat Van Do, Hai Xuan Nguyen, Takao Kataoka
Publikováno v:
BioChem, Vol 1, Iss 3, Pp 174-189 (2021)
Tumor necrosis factor α (TNF-α) induces the nuclear factor κB (NF-κB) signaling pathway via TNF receptor 1 (TNF-R1). We recently reported that isopanduratin A inhibited the TNF-α-induced NF-κB signaling pathway in human lung adenocarcinoma A549
Externí odkaz:
https://doaj.org/article/ed5b11732813423e967bce74278ab1cc
Akademický článek
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Akademický článek
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Autor:
Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Jörg W Bartsch, Stanley R Riddell, Harald Steiner, Stefan F Lichtenthaler
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp n/a-n/a (2022)
Abstract Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly unders
Externí odkaz:
https://doaj.org/article/9be7449636e44c638a2a638ecfb8a4fe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
TNFα converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and pro-inflammatory mediators. In Crohn’s disease (CD), TACE activity is upregulated, resulting in a mark
Externí odkaz:
https://doaj.org/article/64b067a8c8d84adabe734e331480e852
Publikováno v:
Pathogens, Vol 12, Iss 4, p 593 (2023)
The shedding of cell surface receptors may bring synergistic outcomes through the loss of receptor-mediated cell signaling and competitive binding of the shed soluble receptor to its ligand. Thus, soluble receptors have both biological importance and
Externí odkaz:
https://doaj.org/article/3bfbb82b6df44699a25cf4d8f31d55cb
Akademický článek
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