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Akademický článek

Interventions during Early Infection: Opening a Window for an HIV Cure?

Autor: Christopher R. Hiner, April L. Mueller, Hang Su, Harris Goldstein

Publikováno v: Viruses, Vol 16, Iss 10, p 1588 (2024)

Although combination antiretroviral therapy (ART) has been a landmark achievement for the treatment of human immunodeficiency virus (HIV), an HIV cure has remained elusive. Elimination of latent HIV reservoirs that persist throughout HIV infection is

Externí odkaz: https://doaj.org/article/de68b5a0fb304d55bc9aea030444186b

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Akademický článek

Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation

Autor: Alexis Yero, Tao Shi, Julien A. Clain, Ouafa Zghidi-Abouzid, Gina Racine, Cecilia T. Costiniuk, Jean-Pierre Routy, Jérôme Estaquier, Mohammad-Ali Jenabian

Publikováno v: Viruses, Vol 16, Iss 10, p 1609 (2024)

HIV infection significantly affects the frequencies and functions of immunoregulatory CD3+CD4−CD8− double-negative (DN) T-cells, while the effect of early antiretroviral therapy (ART) initiation on these cells remains understudied. DN T-cell subs

Externí odkaz: https://doaj.org/article/ae57dd0368cc415c972bb1891580decd

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Akademický článek

Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir

Autor: Jozefien De Clercq, Marie-Angélique De Scheerder, Virginie Mortier, Chris Verhofstede, Stefaan J. Vandecasteele, Sabine D. Allard, Coca Necsoi, Stéphane De Wit, Sarah Gerlo, Linos Vandekerckhove

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

BackgroundDespite the beneficial effects of antiretroviral therapy (ART) initiation during acute HIV infection (AHI), residual immune activation remains a hallmark of treated HIV infection.MethodsPlasma concentrations of 40 mediators were measured lo

Externí odkaz: https://doaj.org/article/bf29fbebcf7e4ae69d0b09795c182563

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Akademický článek

The build-up of stock of stable integrated proviruses overtime explains the difficulty in reducing HIV-1 DNA levels when treatment is initiated at the chronic stage of the infection

Autor: Gilbert Mchantaf, Antoine Cheret, Adeline Melard, Asma Essat, Elise Gardiennet, Rebecca Bauer, Caroline Charre, Vincent Meiffredy, Lionel Piroth, Cécile Goujard, Laurence Meyer, Véronique Avettand-Fenoel

Publikováno v: Journal of Virus Eradication, Vol 9, Iss 4, Pp 100357- (2023)

Background: Understanding factors affecting the size and the evolution of the HIV reservoir is essential for the development of curative strategies. This study aimed to assess the impact of antiretroviral therapy (ART) initiated during primary infect

Externí odkaz: https://doaj.org/article/b1252e915fef4f8583db7a4cedaa010f

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Akademický článek

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Akademický článek

Persistent T cell proliferation and MDSCs expansion precede incomplete CD4+ T cell recovery in people with acute HIV-1 infection with early ART

Autor: Zhen Li, Ping Yan, Rui Wang, Xiaofan Lu, Yang Zhang, Bin Su, Xin Zhang, Lin Yuan, Zhiying Liu, Wei Jiang, Tong Zhang, Hao Wu, Xiaojie Huang

Publikováno v: Heliyon, Vol 9, Iss 5, Pp e15590- (2023)

HIV-1 infection causes T cell dysfunction that cannot be fully restored by anti-retroviral therapy (ART). Myeloid-derived suppressor cells (MDSCs) expand and suppress T cell function during viral infection. In this study, we evaluated the dynamics of

Externí odkaz: https://doaj.org/article/c8e7f8d4d9a348ef856f4eed6cad4d37

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Akademický článek

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

Autor: Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann, Thumbi Ndung’u

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)

Abstract Introduction Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed th

Externí odkaz: https://doaj.org/article/12144ae325134e809d1d43e98283a822

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Akademický článek

'More than Just a Poet': Konstantin Batiushkov as an Art Critic, Art Manager, and Art Brut Painter

Autor: Igor Pilshchikov

Publikováno v: Arts, Vol 11, Iss 6, p 126 (2022)

This paper focuses on the Russian Golden Age author Konstantin Batiushkov’s involvement with fine arts. He is recognized as an exquisite elegist, an immediate predecessor of Alexander Pushkin in poetry, and “a pioneer of Russian Italomania.” Mu

Externí odkaz: https://doaj.org/article/be22d1ef057e4a20bfa40763358bf8d7

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Akademický článek

Impact of Early Versus Late Antiretroviral Treatment Initiation on Naive T Lymphocytes in HIV-1-Infected Children and Adolescents – The-ANRS-EP59-CLEAC Study

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundThe early initiation of antiretroviral therapy (ART) in HIV-1-infected infants reduces mortality and prevents early CD4 T-cell loss. However, the impact of early ART on the immune system has not been thoroughly investigated in children over

Externí odkaz: https://doaj.org/article/d9809fbebb3b49b08035fd4ff70cc459

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Akademický článek

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