Zobrazeno 1 - 10
of 181
pro vyhledávání: '"eNOS, endothelial Nitric oxide synthase"'
Autor:
Stefano Ministrini, Yustina M. Puspitasari, Georgia Beer, Luca Liberale, Fabrizio Montecucco, Giovanni G. Camici
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions. SIRT1 localizes in the nucleus and cytoplasm, and is implicated i
Externí odkaz:
https://doaj.org/article/3335568b4f244afba1aff86ef947e3f1
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • AAV9 vectors can upregulate Rxfp1 mRNA in murine heart after intravenous injection. • RXFP1 upregulation sensitizes the left ventricle to relaxin-induced inotropy. • RXFP1 overexpression protects heart from isc
Highlights • AAV9 vectors can upregulate Rxfp1 mRNA in murine heart after intravenous injection. • RXFP1 upregulation sensitizes the left ventricle to relaxin-induced inotropy. • RXFP1 overexpression protects heart from isc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a31f53e218adc4b13d0aee6c68b39a7
https://doi.org/10.1016/j.jacbts.2021.10.012
https://doi.org/10.1016/j.jacbts.2021.10.012
Autor:
Susana Gorzalczany, Zahira Deza, Giselle Romero Caimi, Rocío Castilla, María Inés Rosón, Laura Alvarez, Patricia Bonazzola
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1599-1606 (2021)
Toxicology Reports, Vol 8, Iss, Pp 1599-1606 (2021)
Graphical abstract
Highlights • Subchronic HCB-administration in male rats generates arterial hypertension. • AT1 activity is involved in HCB- induced hypertension. • AT1 activity is involved in arterial morphological changes caused by HCB
Highlights • Subchronic HCB-administration in male rats generates arterial hypertension. • AT1 activity is involved in HCB- induced hypertension. • AT1 activity is involved in arterial morphological changes caused by HCB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a5c216511354ae57e2280ba80d3d23
http://europepmc.org/articles/PMC8424126
http://europepmc.org/articles/PMC8424126
Autor:
Bruce D. Hammock, A. F. S. Mello, Natalie J. Török, Fawaz G. Haj, Jun Yang, Ming-Fo Hsu, Bryan Chu, Christophe Morisseau, Jeff Cheng, Shinichiro Koike
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 815-830 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a37aec2ab2970ef64d585a65ffea8d3
http://www.sciencedirect.com/science/article/pii/S2352345X20301624
http://www.sciencedirect.com/science/article/pii/S2352345X20301624
Autor:
Oluwafunke A. Ajayi, Moses C. Antiya, Dorcas Ibukun Akinloye, Adio Jamiu Akamo, Samuel O. Faseun, Gogonte Hezekiah Amah, O E Eteng, O. O. Adeleye, Regina Ngozi Ugbaja, Oluwatosin A. Dosumu
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1803-1813 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Naringin inhibits and/or scavenge in vitro free radicals. • Exposure to cyclophosphamide (CYCP) invoked erythrocytotoxicity. • Erythrocytotoxicity was characterized by oxidative stress and dyslipidaemia. •
Highlights • Naringin inhibits and/or scavenge in vitro free radicals. • Exposure to cyclophosphamide (CYCP) invoked erythrocytotoxicity. • Erythrocytotoxicity was characterized by oxidative stress and dyslipidaemia. •
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638b70b3cd7e017a33c222630706c3f1
http://www.sciencedirect.com/science/article/pii/S2214750021001839
http://www.sciencedirect.com/science/article/pii/S2214750021001839
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 10, Iss 6, Pp 570-576 (2020)
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine
Background and aim Renal ischemia-reperfusion is associated with inflammation and oxidative stress. As a major compound in black pepper, piperine has anti-inflammatory and anti-oxidative properties. In present study, the protective effects of oral ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79b3cb28c890ebbad2250fb1097116f
http://www.sciencedirect.com/science/article/pii/S2225411019304432
http://www.sciencedirect.com/science/article/pii/S2225411019304432
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 9, Pp 1101-1111 (2020)
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal : SPJ
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, which is accompanied by progressive joint damage and disability. The intolerability of conventional antirheumatic drugs by some patients necessitates the search for effective antirheuma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955123f7fe28b608ccba43d266079aeb
https://doi.org/10.1016/j.jsps.2020.07.011
https://doi.org/10.1016/j.jsps.2020.07.011
Autor:
Hossam M. Abdallah, Gamal A. Mohamed, Ali M. El-Halawany, Martin K. Safo, Noura A. Hassan, Hany M. El-Bassossy
Publikováno v:
Journal of Advanced Research, Vol 24, Iss, Pp 273-279 (2020)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • Methanol extract of Psiadia punctulata (MAPP) produced a significant vasodilation. • Chloroform fraction and its methylated flavonoids were responsible for this effect. • Vasodilation is referred to endothel
Highlights • Methanol extract of Psiadia punctulata (MAPP) produced a significant vasodilation. • Chloroform fraction and its methylated flavonoids were responsible for this effect. • Vasodilation is referred to endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e154d40b7f6c70738bd46a118a460f
http://www.sciencedirect.com/science/article/pii/S2090123220300023
http://www.sciencedirect.com/science/article/pii/S2090123220300023
Publikováno v:
Journal of Ginseng Research, Vol 44, Iss 4, Pp 538-543 (2020)
Journal of Ginseng Research
Journal of Ginseng Research
Cardiovascular diseases are a rapidly growing epidemic with high morbidity and mortality. There is an urgent need to develop nutraceutical-based therapy with minimum side effects to reduce cardiovascular risk. Panax ginseng occupies a prominent statu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7cd737611684ea5e87a667bd3a4d0d
http://www.sciencedirect.com/science/article/pii/S1226845320300567
http://www.sciencedirect.com/science/article/pii/S1226845320300567
Autor:
Matthias R. Meyer, Matthias Barton
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • The role of ERα non-nuclear signaling in female heart failure was investigated, using a novel mouse line in which ERα non-nuclear signaling was selectively disrupted by inhibiting the interaction between ERα and
Highlights • The role of ERα non-nuclear signaling in female heart failure was investigated, using a novel mouse line in which ERα non-nuclear signaling was selectively disrupted by inhibiting the interaction between ERα and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b353abdb69e8f5cf341a6505d8e5ce74
http://europepmc.org/articles/PMC7091503
http://europepmc.org/articles/PMC7091503