Zobrazeno 1 - 10
of 1 015
pro vyhledávání: '"eIF5A"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Patients with distant metastasis of head and neck squamous cell carcinoma (HNSCC) often have a poor prognosis. However, early diagnosis of distant metastasis is challenging in clinical practice, and distant metastasis is often only detected
Externí odkaz:
https://doaj.org/article/39c9f12e8d7d4e789a4de67a64fd8c85
Autor:
Ruocen Liao, Xingyu Chen, Qianhua Cao, Longchang Bai, Chenglong Ma, Zhijun Dai, Chenfang Dong
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer due to its aggressive characteristics and lack of effective therapeutics. However, the mechanism underlying its aggressiveness remains largely unclear
Externí odkaz:
https://doaj.org/article/93e5aa0bfb9b45c9940ef3095bd9918f
Autor:
Yaqi Zhong, Xingte Chen, Shiji Wu, Huipeng Fang, Liang Hong, Lingdong Shao, Lei Wang, Junxin Wu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundRadiotherapy (RT) is a critical component of treatment for locally advanced rectal cancer (LARC), though patient response varies significantly. The variability in treatment outcomes is partly due to the resistance conferred by cancer stem c
Externí odkaz:
https://doaj.org/article/90843e0c817348cebab9de67267f8439
Autor:
Rocío Seoane, Tomás Lama-Díaz, Antonia María Romero, Ahmed El Motiam, Arantxa Martínez-Férriz, Santiago Vidal, Yanis H. Bouzaher, María Blanquer, Rocío M. Tolosa, Juan Castillo Mewa, Manuel S. Rodríguez, Adolfo García-Sastre, Dimitris Xirodimas, James D. Sutherland, Rosa Barrio, Paula Alepuz, Miguel G. Blanco, Rosa Farràs, Carmen Rivas
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-29 (2024)
Abstract Background The eukaryotic translation initiation protein eIF5A is a highly conserved and essential factor that plays a critical role in different physiological and pathological processes including stress response and cancer. Different proteo
Externí odkaz:
https://doaj.org/article/5445da8fe38f4f038ef6b01ffaca5172
Autor:
Eva Martin-Solana, Irene Diaz-Lopez, Yamina Mohamedi, Ivan Ventoso, Jose-Jesus Fernandez, Maria Rosario Fernandez-Fernandez
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106488- (2024)
Given their highly polarized morphology and functional singularity, neurons require precise spatial and temporal control of protein synthesis. Alterations in protein translation have been implicated in the development and progression of a wide range
Externí odkaz:
https://doaj.org/article/1c6a58c940e74cd48db0cbbcab08e5a8
Autor:
Shima Nakanishi, John L. Cleveland
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8171 (2024)
The unique amino acid hypusine [Nε-(4-amino-2-hydroxybutyl)lysine] is exclusively formed on the translational regulator eukaryotic initiation factor 5A (eIF5A) via a process coined hypusination. Hypusination is mediated by two enzymes, deoxyhypusine
Externí odkaz:
https://doaj.org/article/4a7495598e44402996da91b819373da2
Autor:
Shafiya Imtiaz Rafiqi, Ahmad Aldasouqi, Sarah Faisal, Salauddin Qureshi, Sandesh Dewan, Aneeba Farooqi, Asif Mahmood, Shahnawaz Imam
Publikováno v:
Translation, Vol 11, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/2b6aa40e258547bc973096917d314f6f
Autor:
Akihito Nakajima, Tomoyoshi Shibuya, Takako Yao, Tsutomu Fujimura, Kimie Murayama, Ko Okumura, Akihito Nagahara, Yoshinori Seko
Publikováno v:
Medicina, Vol 60, Iss 4, p 539 (2024)
Oxidative stress is implicated in the pathogenesis of various acute disorders including ischemia/reperfusion injury, ultraviolet/radiation burn, as well as chronic disorders such as dyslipidemia, atherosclerosis, diabetes mellitus, chronic renal dise
Externí odkaz:
https://doaj.org/article/6f9abd4f49644a9cbd7d25febe5f1a15
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1766 (2024)
Programmed ribosomal frameshifting (PRF) exists in all branches of life that regulate gene expression at the translational level. The eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved protein essential in all eukaryotes. It is
Externí odkaz:
https://doaj.org/article/4288bd0fcfbc40c48af7d42572f6c7de
Autor:
Leah R. Padgett, Mollie R. Shinkle, Spencer Rosario, Tracy Murray Stewart, Jackson R. Foley, Robert A. Casero, Jr., Myung Hee Park, Wendy K. Chung, Teresa L. Mastracci
Publikováno v:
HGG Advances, Vol 4, Iss 3, Pp 100206- (2023)
Summary: DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore acti
Externí odkaz:
https://doaj.org/article/e7637e4d3aca4a68831a2b5aa9c94073