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Akademický článek

Isobaric Tags for Relative and Absolute Quantitation Identification of Blood Proteins Relevant to Paroxetine Response in Patients With Major Depressive Disorder

Autor: Chin-Chuen Lin, Hung Su, Jentaie Shiea, Tiao-Lai Huang

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

ObjectivesIsobaric tags for relative and absolute quantitation (iTRAQ) is a proteomic investigation that could be utilized for rapid identification and quantification of proteins, which we would use to identify differentially expressed proteins in tr

Externí odkaz: https://doaj.org/article/f352ccfcd2ca498d8c766e889b9ec5f8

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Akademický článek

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

Autor: Lindsey D. Goodman, Mercedes Prudencio, Ananth R. Srinivasan, Olivia M. Rifai, Virginia M.-Y. Lee, Leonard Petrucelli, Nancy M. Bonini

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)

Abstract The discovery of an expanded (GGGGCC)n repeat (termed G4C2) within the first intron of C9orf72 in familial ALS/FTD has led to a number of studies showing that the aberrant expression of G4C2 RNA can produce toxic dipeptides through repeat-as

Externí odkaz: https://doaj.org/article/7019a317a5864515b0fcf28779ee886e

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Akademický článek

RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H

Autor: Sirui Zhang, Yufang Bao, Xianfeng Shen, Yunjian Pan, Yue Sun, Man Xiao, Kexuan Chen, Huanhuan Wei, Ji Zuo, David Saffen, Wei-Xing Zong, Yihua Sun, Zefeng Wang, Yongbo Wang

Publikováno v: EBioMedicine, Vol 61, Iss , Pp 103067- (2020)

Background: RNA splicing defects are emerging molecular hallmarks of cancer. The gene encoding splicing factor RNA binding motif protein 10 (RBM10) has been found frequently mutated in various types of cancer, particularly lung adenocarcinoma (LUAD),

Externí odkaz: https://doaj.org/article/29f1f99692e3423ca848ddddb7179f19

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Akademický článek

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RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H

Autor: David Saffen, Kexuan Chen, Xianfeng Shen, Yunjian Pan, Huanhuan Wei, Yue Sun, Ji Zuo, Man Xiao, S.H. Zhang, Yongbo Wang, Yufang Bao, Wei-Xing Zong, Zefeng Wang, Yihua Sun

Publikováno v: EBioMedicine, Vol 61, Iss, Pp 103067-(2020)
EBioMedicine

Background RNA splicing defects are emerging molecular hallmarks of cancer. The gene encoding splicing factor RNA binding motif protein 10 (RBM10) has been found frequently mutated in various types of cancer, particularly lung adenocarcinoma (LUAD),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc393463e19babfb7ae837d33fb93e80
http://www.sciencedirect.com/science/article/pii/S2352396420304436

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eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

Autor: Ananth R. Srinivasan, Mercedes Prudencio, Nancy M. Bonini, Leonard Petrucelli, Olivia M. Rifai, Lindsey D. Goodman, Virginia M.-Y. Lee

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)

The discovery of an expanded (GGGGCC)n repeat (termed G4C2) within the first intron of C9orf72 in familial ALS/FTD has led to a number of studies showing that the aberrant expression of G4C2 RNA can produce toxic dipeptides through repeat-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7d513a540eb3b1da2d2c8eedbb2b3c
https://doi.org/10.1186/s40478-019-0711-9

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A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy

Autor: Gord von Campe, Andrea Borenich, Stefan L Leber, Christina Skofler, Nicole Golob-Schwarzl, Stefanie Krassnig, Serge Weis, Marlene Mayer, Martin Benesch, Nadine Gantenbein, Kariem Mahdy-Ali, Anna Maria Birkl-Toeglhofer, Marlene Leoni, Andrea Raicht, Christina Wohlrab, Martin Asslaber, Johannes Haybaeck, Christoph Schatz

Publikováno v: Cancers
Cancers, Vol 13, Iss 1482, p 1482 (2021)
Volume 13
Issue 6

Simple Summary Gliomas are brain tumors with currently limited therapy options. Glioma growth and proliferation is regulated by the mTOR pathway together with eukaryotic initiation factors (eIFs). In this work we show a profound basic characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da627474275ea965a82cec03275dddb1
https://doi.org/10.3390/cancers13061482

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Key contribution of eIF4H-mediated translational control in tumor promotion

Autor: Vaysse, Charlotte, Philippe, Celine, Yvan Martineau, Quelen, Cathy, Hieblot, Corinne, Renaud, Claire, Nicaise, Yvan, Desquesnes, Aurore, Pannese, Maria, Filleron, Thomas, Escourrou, Ghislaine, Lawson, Malcolm, Rintoul, Robert C., Delisle, Marie Bernadette, Pyronnet, Stephane, Brousset, Pierre, Prats, Herve, Touriol, Christian

Publikováno v: Oncotarget
ResearcherID

Dysregulated expression of translation initiation factors has been associated with carcinogenesis, but underlying mechanisms remains to be fully understood. Here we show that eIF4H (eukaryotic translation initiation factor 4H), an activator of the RN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fc1085d81aea13f687dedd775523d8

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