Zobrazeno 1 - 10
of 24
pro vyhledávání: '"dynamic colon model (DCM)"'
Autor:
Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 882 (2023)
A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrat
Externí odkaz:
https://doaj.org/article/971020ba2e1c4f99a5d83f9bf2223142
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2193 (2022)
The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the D
Externí odkaz:
https://doaj.org/article/81af068eed1445bfb1774a0549b819c5
Autor:
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 184 (2022)
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic
Externí odkaz:
https://doaj.org/article/7613cdd0ba5543b0814e9a526b2a501f
Autor:
Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1545 (2021)
Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us
Externí odkaz:
https://doaj.org/article/68d9ca066dec4482b4222dd190fd60e2
Autor:
Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 659 (2020)
This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particl
Externí odkaz:
https://doaj.org/article/b84b4d5fab48443d81b7f955d4d3103c
Akademický článek
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Autor:
Luca Marciani, Alessio Alexiadis, Caroline Hoad, Mark Simmons, Hannah Batchelor, Connor O'Farrell, Konstantinos Stamatopoulos, Sarah Sulaiman, Michael Schütt
Publikováno v:
Pharmaceutics; Volume 14; Issue 1; Pages: 184
Pharmaceutics, Vol 14, Iss 184, p 184 (2022)
Pharmaceutics
Pharmaceutics, Vol 14, Iss 184, p 184 (2022)
Pharmaceutics
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514ce9977ad8a1be51509d8164b6dac9
https://strathprints.strath.ac.uk/79184/1/Sch_tt_etal_Pharmaceutics_2022_Simulating_the_hydrodynamic_conditions_of_the_human_ascending_colon_a_digital_twin.pdf
https://strathprints.strath.ac.uk/79184/1/Sch_tt_etal_Pharmaceutics_2022_Simulating_the_hydrodynamic_conditions_of_the_human_ascending_colon_a_digital_twin.pdf
Akademický článek
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Autor:
Hannah Batchelor, Luca Marciani, Caroline L. Hoad, Mark J.H. Simmons, Connor O’Farrell, Konstantinos Stamatopoulos, Sarah Sulaiman
Publikováno v:
Pharmaceutics
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1545, p 1545 (2021)
Volume 13
Issue 10
Pharmaceutics, Vol 13, Iss 1545, p 1545 (2021)
Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.