Zobrazeno 1 - 10
of 62
pro vyhledávání: '"dynamic colon model (DCM)"'
Autor:
Stamatopoulos, Konstantinos1 (AUTHOR) konstantinos.x.stamatopoulos@gsk.com, O'Farrell, Connor2 (AUTHOR), Simmons, Mark J. H.2 (AUTHOR), Batchelor, Hannah K.3 (AUTHOR), Mistry, Nena1 (AUTHOR)
Publikováno v:
Pharmaceutics. Mar2023, Vol. 15 Issue 3, p882. 15p.
Autor:
Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 882 (2023)
A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrat
Externí odkaz:
https://doaj.org/article/971020ba2e1c4f99a5d83f9bf2223142
Autor:
Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 659 (2020)
This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particl
Externí odkaz:
https://doaj.org/article/b84b4d5fab48443d81b7f955d4d3103c
Akademický článek
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Akademický článek
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Autor:
Luca Marciani, Caroline L. Hoad, Mark J.H. Simmons, Mark Goldstein, Hannah Batchelor, Sarah Sulaiman, Connor O’Farrell, Konstantinos Stamatopoulos, Sharad Karandikar
Publikováno v:
Pharmaceutics
Volume 12
Issue 7
Pharmaceutics, Vol 12, Iss 659, p 659 (2020)
Volume 12
Issue 7
Pharmaceutics, Vol 12, Iss 659, p 659 (2020)
This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particl
Publikováno v:
Drug Week; 4/14/2023, p1957-1957, 1p
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 108
The human proximal colon has been considered a favourable site to deliver drugs for local and systemic treatments. However, modified dosage forms face a complex and dynamically changing colonic environment. Therefore, it has been realized that in add
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2193 (2022)
The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the D
Externí odkaz:
https://doaj.org/article/81af068eed1445bfb1774a0549b819c5
Autor:
Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1545 (2021)
Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us
Externí odkaz:
https://doaj.org/article/68d9ca066dec4482b4222dd190fd60e2