Zobrazeno 1 - 10
of 34
pro vyhledávání: '"dynamic colon model"'
Autor:
Dariah-Sohreh Seradj, Regine Beeck, Annika Haase, Julius Krause, Philipp Schick, Werner Weitschies
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1128 (2023)
The microbiome of the colon is characterized by its great diversity. This varies not only intra- but also interindividually and is influenced by endogenous and exogenous factors, such as dietary and lifestyle factors. The aim of this work was to inve
Externí odkaz:
https://doaj.org/article/3c8e6386dd9647209ec07db6e4e8123c
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the diss
Externí odkaz:
https://doaj.org/article/a28df2e36d804c7d9e1be05512fe9968
Autor:
Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 882 (2023)
A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrat
Externí odkaz:
https://doaj.org/article/971020ba2e1c4f99a5d83f9bf2223142
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2193 (2022)
The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the D
Externí odkaz:
https://doaj.org/article/81af068eed1445bfb1774a0549b819c5
Autor:
Regine Beeck, Annemarie Dols, Felix Schneider, Dariah-Sohreh Seradj, Julius Krause, Philipp Schick, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1049 (2022)
In recent years, the colon has become a hot topic in biopharmaceutical research as several in vitro models of the human colon have been presented. A major focus is on the characterization of the microbiota and its capabilities. The aim of the present
Externí odkaz:
https://doaj.org/article/dcf1aba2d638418ea9fda8379c61556c
Autor:
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 184 (2022)
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic
Externí odkaz:
https://doaj.org/article/7613cdd0ba5543b0814e9a526b2a501f
Autor:
Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1545 (2021)
Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us
Externí odkaz:
https://doaj.org/article/68d9ca066dec4482b4222dd190fd60e2
Akademický článek
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Autor:
Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 659 (2020)
This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particl
Externí odkaz:
https://doaj.org/article/b84b4d5fab48443d81b7f955d4d3103c
Akademický článek
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