Zobrazeno 1 - 10
of 1 927
pro vyhledávání: '"dual-targeting"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 5283-5297 (2024)
Yashi Ruan,1,* Lixia Guan,2,* Yuting Wang,2 Yifei Geng,2 Xiaoran Wang,2 Miao-Miao Niu,2 Li Yang,1 Cen Xu,1 Zhen Xu1 1Department of Urology, Reproductive Medicine and Oncology, The Affiliated Taizhou People’s Hospital of Nanjing Medical Univ
Externí odkaz:
https://doaj.org/article/8b93015337b3453ea750abf4825b2597
Autor:
Xiaoling Guan, Xiaowei Xu, Yiwen Tao, Xiaohua Deng, Linlong He, Zhongxiao Lin, Jishuo Chang, Jionghua Huang, Dazhi Zhou, Xiyong Yu, Minyan Wei, Lingmin Zhang
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Epigenetic regulation has emerged as a promising therapeutic strategy for lung cancer treatment, which can facilitate the antitumor responses by modulating epigenetic dysregulation of target proteins in lung cancer. The proteolysis-targeting
Externí odkaz:
https://doaj.org/article/844e77478f364ceea0fb44ed6bbef605
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 9121-9143 (2024)
Yanan Huang,1,* Yunfeng Wang,2,* Tianyu Zheng,1,* Shuang Nie,1 Yanli Wang,3 Hui Shen,1 Fengfeng Mo1 1Department of Naval Nutrition and Food Hygiene, Faculty of Navy Medicine, Naval Medical University, Shanghai, People’s Republic of Chin
Externí odkaz:
https://doaj.org/article/48127cf3b1c74377bafbcaa70a919a4e
Publikováno v:
Pharmaceutical Science Advances, Vol 2, Iss , Pp 100046- (2024)
Patients with advanced hepatocellular carcinoma (HCC) are not sensitive to sorafenib (SOR), therefore, combination therapy is required. In this study, an improved thin-film dispersion and post-insertion anchoring technique was utilized to construct a
Externí odkaz:
https://doaj.org/article/8b12dfb9ac414d6d9d55cb6e67f740ac
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractColorectal cancer (CRC) is one of the most common cancers worldwide. Nowadays, owing to the complex mechanism of tumorigenesis, simultaneous inhibition of multiple targets is an important anticancer strategy. Recent studies have demonstrated
Externí odkaz:
https://doaj.org/article/c0259a46e9354907be2849c602177314
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractLiver cancer exhibits a high degree of heterogeneity and involves intricate mechanisms. Recent research has revealed the significant role of histone lysine methylation and acetylation in the epigenetic regulation of liver cancer development.
Externí odkaz:
https://doaj.org/article/22b604f5c6384211ba65b8aee18b01df
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Given that overexpression of Poly (ADP-ribose) polymerase-1 (PARP1) and Neuropilin-1 (NRP1) is implicated in the pathogenesis of human breast cancer, the design of dual PARP1/NRP1 inhibitors has wide therapeutic prospect. However, there have been no
Externí odkaz:
https://doaj.org/article/3f6e795c28f545b78dbadbe06cee4270
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Simultaneous inhibition of two or more pathways is playing a crucial role in the treatment of hepatocellular carcinoma with complex and diverse pathogenesis. However, there have been no reports of dual-targeting inhibitors for protein kinase membrane
Externí odkaz:
https://doaj.org/article/d02bc6eaeef64b15b41a08e6694482ae
Autor:
Shang Chen, Yan He, Xin Huang, Yao Shen, Qingshuang Zou, Gun Yang, Li Fu, Quan Liu, Dixian Luo
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Tumor-associated macrophages (TAMs) are a promising target for cancer immunotherapy, but delivering therapeutic agents to TAMs within the tumor microenvironment (TME) is challenging. In this study, a photosensitive, dual-targeting nanopartic
Externí odkaz:
https://doaj.org/article/326590191cff4ad8b056694ab5be7f7e