Zobrazeno 1 - 10
of 1 770
pro vyhledávání: '"dual inhibitors"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-58 (2024)
Abstract Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing protein structures, facilitating the repair or degradation of damaged proteins, and maintaining proteostasis and cellular functions. Extensive rese
Externí odkaz:
https://doaj.org/article/4d5d2c5da47d42cea03597681a210e8a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Discovering effective anti-cancer agents poses a formidable challenge given the limited efficacy of current therapeutic modalities against various cancer types due to intrinsic resistance mechanisms. Cancer immunochemotherapy is an alternati
Externí odkaz:
https://doaj.org/article/42701beaf4914ea4a2bf7603ad31ff5b
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractDisruption of p53-MDM2/MDMX interaction by smaller inhibitors is a promising therapeutic intervention gaining tremendous interest. However, no MDM2/MDMX inhibitors have been marketed so far. Drug repurposing is a validated, practical approach
Externí odkaz:
https://doaj.org/article/6583953be42c4712a3b9c7c2884caedd
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101500- (2024)
Alzheimer’s disease (AD) remains a significant global health challenge, necessitating the exploration of novel therapeutic strategies. AD is a neurodegenerative disease characterized by the formation of amyloid-β (Aβ) plaques and neurofibrillary
Externí odkaz:
https://doaj.org/article/b1c53864cb834fb2b1aa1a920587493b
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Alzheimer’s disease (AD) is a progressive brain disease characterised by progressive memory loss and cognition impairment, ultimately leading to death. There are three FDA-approved acetylcholinesterase inhibitors (donepezil, rivastigmine, and galan
Externí odkaz:
https://doaj.org/article/80579e54291b4fdcad0b514c3e1209a9
Autor:
Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Clinical treatment by FDA-approved ROS1/ALK inhibitor Crizotinib significantly improved the therapeutic outcomes. However, the emergence of drug resistance, especially driven by acquired mutations, have become an inevitable problem and worsened the c
Externí odkaz:
https://doaj.org/article/0b5c5c07baf041f39b81de8cf3a2b193
Autor:
Chunfang Hu, Ting Guo, Yunting Zou, Junyi Gao, Yi Gao, Miaomiao Niu, Yang Xia, Xiaozhou Shen, Jindong Li
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Both receptor-binding domain in spike protein (S-RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human neuropilin-1 (NRP1) are important in the virus entry, and their concomitant inhibition may become a potential strategy aga
Externí odkaz:
https://doaj.org/article/21d842aca6c84939880273163cc38679
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 59 (2023)
Abstract Someoxoquinoline-acylhydrazonederivativesshowedactivityagainst HumanImmunodeficiency Virus type 1 (HIV-1). These compounds must also be active against Herpes Simplex Virus type 1 (HSV-1) by an inhibition mechanism where they interact with th
Externí odkaz:
https://doaj.org/article/ce5c6c4238b248c3974794312c74b87f
Autor:
Babatunde Oluwatoyin, Hameed Shehryar, Mbachu Kingsley Adibe, Saleem Faiza, Chigurupati Sridevi, Wadood Abdul, Ur Rehman Ashfaq, Venugopal Vijayan, Khan Khalid Mohammed, Taha Muhammad, Ekundayo Olusegun, Khan Maria Aqeel
Publikováno v:
Journal of the Serbian Chemical Society, Vol 88, Iss 9, Pp 825-840 (2023)
In search of potent inhibitors of cholinesterase enzymes and antioxidant agents, synthetic derivatives of dihydroquinazolin-4(1H)-one (1–38) were evaluated as potential anti-Alzheimer agents through in vitro acetylcholinesterase (AChE) and butyrylc
Externí odkaz:
https://doaj.org/article/ee83b67ffc4e457ca1129f9da7db6c04
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/5d394718039840a5970976271195073a