Zobrazeno 1 - 10
of 2 641
pro vyhledávání: '"drug transporters"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 5, Pp 1924-1938 (2024)
Drug transporters are essential players in the transmembrane transport of a wide variety of clinical drugs. The broad substrate spectra and versatile distribution pattern of these membrane proteins infer their pharmacological and clinical significanc
Externí odkaz:
https://doaj.org/article/3b99dacf3a1a4845a22d2f4cf83dc31d
Autor:
Uppala Radhakrishna, Rupa Radhakrishnan, Lavanya V. Uppala, Srinivas B. Muvvala, Jignesh Prajapati, Rakesh M. Rawal, Ray O. Bahado-Singh, Senthilkumar Sadhasivam
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a consequence of in-utero exposure to prenatal maternal opioids, resulting in the manifestation of symptoms like irritability, feeding problems, tremors, and withdrawal signs. Opioid use disorde
Externí odkaz:
https://doaj.org/article/0d6254b7eb4640eb8e65161d5031121a
Autor:
Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating the intestinal absorption and metabolism of orally administered drugs. However, it is difficult to generate la
Externí odkaz:
https://doaj.org/article/0d9f9919464a474da5281380fc90759e
Publikováno v:
Membranes, Vol 14, Iss 11, p 223 (2024)
Membrane transporters are expressed in a wide range of tissues in the human organism. These proteins regulate the penetration of various substances such as simple ions, xenobiotics, and an extensive number of therapeutics. ABC and SLC drug transporte
Externí odkaz:
https://doaj.org/article/2937b54d6bd04f1581a0a8bf59e11ae3
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Ulotaront (SEP‐363856) is a TAAR1 agonist, with 5‐HT1A agonist activity, currently in clinical development for the treatment of schizophrenia. In vitro studies indicate ulotaront is an OCT2‐specific inhibitor with IC50 of 1.27 μM. The
Externí odkaz:
https://doaj.org/article/6ab6e839dc2b4529b1b2f4f221971a6c
Autor:
Wen-Jung Lu, Yu-Wei Lian, Chun-Ju Chang, Hsuan-Ju Lin, Chian-Yun Huang, Pang-Hung Hsu, Hong-Ting Lin
Publikováno v:
Antibiotics, Vol 13, Iss 7, p 628 (2024)
Drug-resistant efflux pumps play a crucial role in bacterial antibiotic resistance. In this study, potential efflux pump inhibitors (EPIs) with a diphenylmethane scaffold were screened and evaluated against drug-resistant Escherichia coli. Twenty-fou
Externí odkaz:
https://doaj.org/article/93ef47564aec4e8ba06af365312831ba
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 855 (2024)
The evaluation of transporter-mediated drug–drug interactions (DDIs) during drug development and post-approval contributes to benefit–risk assessment and helps formulate clinical management strategies. The use of endogenous biomarkers, which are
Externí odkaz:
https://doaj.org/article/7cb18cf515ea4c15b52a3e04238439de
Autor:
Min Seo Lee, Jihoon Lee, Minyoung Pang, John Kim, Hyunju Cha, Banyoon Cheon, Min-Koo Choi, Im-Sook Song, Hye Suk Lee
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 799 (2024)
Zastaprazan (JP-1366), a novel potassium-competitive acid blocker, is a new drug for the treatment of erosive esophagitis. JP-1366 is highly metabolized in human, mouse, and dog hepatocytes but moderately metabolized in rat and monkey hepatocytes whe
Externí odkaz:
https://doaj.org/article/d22f1234d718446cb00384ce6e9851c9
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
In 2023, colorectal cancer (CRC) is the third most diagnosed malignancy and the third leading cause of cancer death worldwide. At the time of the initial visit, 20% of patients diagnosed with CRC have metastatic CRC (mCRC), and another 25% who presen
Externí odkaz:
https://doaj.org/article/718681384446464b8a8e9a4e6d195fa2
Publikováno v:
Molecules, Vol 29, Iss 11, p 2482 (2024)
Pseudoginsenoside DQ (PDQ), an ocotillol-type ginsenoside, is synthesized with protopanaxadiol through oxidative cyclization. PDQ exhibits good anti-arrhythmia activity. However, the inhibitory effect of PDQ on the cytochrome 450 (CYP450) enzymes and
Externí odkaz:
https://doaj.org/article/7a68718c18d343b6a0230aae013a4f1c