Výsledky vyhledávání - "drug therapy [Plaque, Amyloid]"

Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis

Autor: Martina Stazi, Sandra Lehmann, M. Sadman Sakib, Tonatiuh Pena-Centeno, Luca Büschgens, Andre Fischer, Sascha Weggen, Oliver Wirths

Publikováno v: Cellular and Molecular Life Sciences
Cellular and molecular life sciences 79(1), 55 (2021). doi:10.1007/s00018-021-04062-8

Epidemiological studies indicate that the consumption of caffeine, the most commonly ingested psychoactive substance found in coffee, tea or soft drinks, reduces the risk of developing Alzheimer’s disease (AD). Previous treatment studies with trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2f2df6abc62be2c342c4546e272e27
https://pubmed.ncbi.nlm.nih.gov/34913091

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BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

Autor: Tanja Blume, Severin Filser, Etienne Herzog, Jochen Herms, Mario M. Dorostkar, Finn Peters, Derya R. Shimshek, Nils Brose, Hazal Salihoglu, Eva Ferreira Rodrigues, Ulf Neumann

Publikováno v: Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9

BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). However, so far pharmacological BACE1 inhibition failed to res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af044c91d1bf50ef951bb3c095454513
https://doi.org/10.1007/s00401-017-1804-9

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Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature reviews / Neuroscience 22(8), 1258-1268 (2019). doi:10.1038/s41593-019-0432-1
NATURE NEUROSCIENCE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer’s disease (AD). Alternative APP processing v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a0f9a5692c67f30d39b2f9105c61ff
http://hdl.handle.net/10261/193936

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Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

Autor: Hugo Vanderstichele, Derya R. Shimshek, Stephan A. Kaeser, Mathias Jucker, Juliane Schelle, Jens C. Göpfert, Matthias Staufenbiel, Erik Stoops, Eva-Maria Mandelkow, Lisa M. Häsler, Thomas O. Joos, Ulf Neumann

Publikováno v: Alzheimer's and dementia 13(6), 701-709 (2017). doi:10.1016/j.jalz.2016.09.005
Alzheimer's and Dementia

Introduction The inhibition of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a main therapeutic approach for the treatment of Alzheimer's disease (AD). We previously reported an age-related increase of tau protein in the cerebros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b80e3a98c39c265443e8e1638197c64
https://pub.dzne.de/record/139312

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Reduced Alzheimer’s Disease Pathology by St. John’s Wort Treatment is Independent of Hyperforin and Facilitated by ABCC1 and Microglia Activation in Mice

Autor: Bernd Walbroel, Cathleen Lange, Björn Feistel, Toni Schumacher, Hans-Jochen Heinze, Timothy F. Sharbel, Sara Crockett, Jens Pahnke, Jacqueline Hofrichter, Markus Krohn

Publikováno v: Current Alzheimer research 10(10), 1057-1069 (2013). doi:10.2174/15672050113106660171

Soluble β -amyloid peptides (A β) and small Aβ oligomers represent the most toxic peptide moieties recognized in brains affected by Alzheimer’s disease (AD). Here we provide the first evidence that specific St. John’s wort (SJW) extracts both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9aabb2954ddf5799f475df84284565
https://doi.org/10.2174/15672050113106660171

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Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment

Autor: Franz-Josef Gildehaus, Matthias Brendel, Janette Carlsen, Anna Jaworska, Peter Bartenstein, Christian Haass, Christina Rötzer, Thomas Luebbers, Johannes Trambauer, Harald Steiner, Johan Bylund, Paul Cumming, Karlheinz Baumann, Jochen Herms, Axel Rominger

Publikováno v: Molecular psychiatry 20(10), 1179-1187 (2015). doi:10.1038/mp.2015.74
Molecular Psychiatry

In a positron-emission tomography (PET) study with the β-amyloid (Aβ) tracer [(18)F]-florbetaben, we previously showed that Aβ deposition in transgenic mice expressing Swedish mutant APP (APP-Swe) mice can be tracked in vivo. γ-Secretase modulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a856cd45d5200ce586d07ac7fc141153
https://pub.dzne.de/record/138131

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Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures

Autor: D Quincy, K Quinn, EF Brigham, Tobias Bonhoeffer, Edith Winkler, Dale Schenk, Christian Haass, Harald Steiner, GS Basi, E Goldbach, Sabine Liebscher, Richard M. Page, K Käfer, Melanie Meyer-Luehmann, Mark Hübener

Publikováno v: Molecular Psychiatry
Europe PubMed Central
Molecular psychiatry 19(8), 937-946 (2013). doi:10.1038/mp.2013.122

The loss of synapses is a strong histological correlate of the cognitive decline in Alzheimer's disease (AD). Amyloid β-peptide (Aβ), a cleavage product of the amyloid precursor protein (APP), exerts detrimental effects on synapses, a process thoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c06e399e4a9b1402a037cce7b8a472
https://pubmed.ncbi.nlm.nih.gov/24061497

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