Výsledky vyhledávání - "drug therapy [Cognition Disorders]"

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

Autor: Gianluigi Forloni, Federica Fusco, Alessio Colombo, Emanuele Nardo, Ottavia Bernocchi, Gloria Biella, Diego Albani, Stefan F. Lichtenthaler

Publikováno v: Journal of Alzheimer's disease 53(3), 1193-1207 (2016). doi:10.3233/JAD-151135

The neuropathological hallmarks of Alzheimer's disease (AD) are extracellular plaques built up by the accumulation of the amyloid-β protein precursor (AβPP)-derived peptide β (Aβ), and intracellular tangles of hyperphosphorylated tau protein. Sir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dfe8bfcc867a7af76d2b0ddff1984d
https://doi.org/10.3233/jad-151135

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Dopaminergic Effect on Non-Motor Symptoms in Late Stage Parkinson's Disease

Autor: Alexander Storch, Peter Hagell, Kristina Rosqvist, Susanne Iwarsson, Per Odin, Maria Nilsson

Publikováno v: Journal of Parkinson's Disease 8(3), 409-420 (2018). doi:10.3233/JPD-181380

Background: Non-motor symptoms (NMS) are common in late stage Parkinson's disease (PD), as the frequency and severity of most of these symptoms increase with advancing disease. Objective: To assess effect of dopaminergic therapy on NMS in late stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf88cbdf173bd88560b719830542314
https://pubmed.ncbi.nlm.nih.gov/30594936

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Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy

Autor: Tursonjan Tokay, Timo Kirschstein, Mischa Uebachs, Katharina Klatte, Maria Kober, David M. Otte, Andreas Zimmer, Leonie Pothmann, Heinz Beck, Lorenz Müller

Publikováno v: The journal of neuroscience 33(32), 13066-13080 (2013). doi:10.1523/JNEUROSCI.5423-12.2013

The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor. In many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617da5f98206b4f6836a014b943fbeb1
https://pub.dzne.de/record/137012

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Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome

Autor: Susanne Schnell, Devon Ryan, Katharina Paesler, Markus Heinen, Moritz M. Hettich, Dan Ehninger

Publikováno v: Neural Plasticity
Neural Plasticity, Vol 2012 (2012)
Neural plasticity 2012, 1-10 (2012). doi:10.1155/2012/467251

Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to various patterns of more selective neuropsychological deficits, including memory impairments. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e87d1be4e7818908f037e8bcda22d8
http://europepmc.org/articles/PMC3405721

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Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics

Autor: Leonhard Lennertz, Michael Wagner, Heinz Häfner, Anna Schuhmacher, Dan Rujescu, Rainald Mössner, Boris B. Quednow, Wolfgang Maier, Petra Franke, Marcella Rietschel, Wolfgang Wölwer, Tim Becker, Jens Benninghoff, Wolfgang Gaebel

Publikováno v: Journal of psychiatric research 46(8), 1073-1080 (2012). doi:10.1016/j.jpsychires.2012.04.021
Journal of Psychiatric Research; Vol 46
Journal of psychiatric research

Serotonergic transmission is considered relevant in the pathophysiology and the treatment of schizophrenia. Tryptophan hydroxylase (TPH) is the rate limiting enzyme in the biosynthesis of serotonin. While the TPH1 gene has been found to be associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794ae0b703ad9890e0efcc11a72840ea
https://pub.dzne.de/record/136586

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Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

Autor: Hochgräfe, Katja, Sydow, Astrid, Mandelkow, Eva-Maria, Matenia, Dorthe, Cadinu, Daniela, Könen, Stefanie, Petrova, Olga, Pickhardt, Marcus, Goll, Petra, Morellini, Fabio, Mandelkow, Eckhard

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications 3(1), 25 (2015). doi:10.1186/s40478-015-0204-4

Introduction Neurofibrillary tangles (NFT) composed of Tau are hallmarks of neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro-aggregant human Tau (2N4R Tau-ΔK280, termed TauΔK) or its repeat domain (TauRD-ΔK280, Ta

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