Výsledky vyhledávání - "drug resistance testing"

Akademický článek

Virological impact of HIV drug-resistance testing in children, adolescents, and adults failing first-line ART in Tanzania

Autor: Shimba Henerico, Eric Lyimo, Abel N. Makubi, Daniel Magesa, Bernard Desderius, Andreas Mueller, John Changalucha, Michael Aloyce, Bence Maziku, Benson R. Kidenya, Samuel E. Kalluvya, Gert Van Zyl, Wolfgang Preiser, Stephen E. Mshana, Christa Kasang

Publikováno v: Journal of Global Antimicrobial Resistance, Vol 39, Iss , Pp 73-81 (2024)

Background: Prospective data on the effectiveness of resistance testing in informing treatment decisions and outcomes in with first-line failure in these settings is limited. This study aimed to assess the virological impact of HIV drug-resistance te

Externí odkaz: https://doaj.org/article/826421cd961a405a82801b14b62cea49

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Akademický článek

Development and Optimization of Oligonucleotide Ligation Assay (OLA) Probes for Detection of HIV-1 Resistance to Dolutegravir

Autor: Ingrid A. Beck, Ceejay L. Boyce, Marley D. Bishop, Yen L. Vu, Amanda Fung, Sheila Styrchak, Nuttada Panpradist, Barry R. Lutz, Lisa M. Frenkel

Publikováno v: Viruses, Vol 16, Iss 7, p 1162 (2024)

The WHO currently recommends dolutegravir (DTG)-based ART for persons living with HIV infection in resource-limited-settings (RLS). To expand access to testing for HIV drug resistance (DR) to DTG in RLS, we developed probes for use in the oligonucleo

Externí odkaz: https://doaj.org/article/5eae2802cfbd4e7381fdb8a745ba669d

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Akademický článek

'I feel drug resistance testing allowed us to make an informed decision': qualitative insights on the role of HIV drug resistance mutation testing among children and pregnant women living with HIV in western Kenya

Autor: Andrea J. Scallon, Shukri A. Hassan, Shirley Rui Qian, Yuandi Gao, Patrick Oyaro, Evelyn Brown, James Wagude, Irene Mukui, Eunice Kinywa, Frederick Oluoch, Francesca Odhiambo, Boaz Oyaro, Leonard Kingwara, Nashon Yongo, Enericah Karauki, Lindah Otieno, Grace C. John-Stewart, Lisa L. Abuogi, Rena C. Patel

Publikováno v: BMC Health Services Research, Vol 23, Iss 1, Pp 1-15 (2023)

Abstract Background Pregnant women and children living with HIV in Kenya achieve viral suppression (VS) at lower rates than other adults. While many factors contribute to these low rates, the acquisition and development of HIV drug resistance mutatio

Externí odkaz: https://doaj.org/article/07396b25b84f4162a914b63c322bdfc2

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Akademický článek

Evaluation of the ABL NGS assay for HIV-1 drug resistance testing

Autor: Thomas Lhossein, Karine Sylvain, Véronique Descamps, Virginie Morel, Baptiste Demey, Etienne Brochot

Publikováno v: Heliyon, Vol 9, Iss 11, Pp e22210- (2023)

HIV evolution and variability around the world requires special monitoring of the viral strains in infected people. High-throughput HIV sequencing and drug resistance testing techniques have become routinely available over the last few years.We condu

Externí odkaz: https://doaj.org/article/7b75d58eb4e741e2b96a2682addabedd

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Akademický článek

HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resistance Mutations in Samples with Low-Level Viral Loads

Autor: Bareng OT, Choga WT, Maphorisa ST, Seselamarumo S, Seatla KK, Mokgethi PT, Maruapula D, Mogwele ML, Ditshwanelo D, Moraka NO, Gobe I, Motswaledi MS, Makhema JM, Musonda R, Shapiro R, Essex M, Novitsky V, Moyo S, Gaseitsiwe S

Publikováno v: Infection and Drug Resistance, Vol Volume 15, Pp 7565-7576 (2022)

Ontlametse T Bareng,1,2 Wonderful T Choga,1,2 Segomotso T Maphorisa,3 Sekgabo Seselamarumo,1 Kaelo K Seatla,1 Patrick T Mokgethi,1,4 Dorcas Maruapula,1,4 Mompati L Mogwele,1 Doreen Ditshwanelo,1,5 Natasha O Moraka,1 Irene Gobe,2 Modisa S Motswaledi,2

Externí odkaz: https://doaj.org/article/846ef3e83d94460f975dd8d7a30b1b13

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Akademický článek

Human Cytomegalovirus (HCMV) Genetic Diversity, Drug Resistance Testing and Prevalence of the Resistance Mutations: A Literature Review

Autor: Ivana Grgic, Lana Gorenec

Publikováno v: Tropical Medicine and Infectious Disease, Vol 9, Iss 2, p 49 (2024)

Human cytomegalovirus (HCMV) is a pathogen with high prevalence in the general population that is responsible for high morbidity and mortality in immunocompromised individuals and newborns, while remaining mainly asymptomatic in healthy individuals.

Externí odkaz: https://doaj.org/article/98f8f87114b0491eab896f2af4ddd711

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Akademický článek

Targeting cancer drug resistance utilizing organoid technology

Autor: Changpeng Chai, Pengfei Ji, Hao Xu, Huan Tang, Zhengfeng Wang, Hui Zhang, Wence Zhou

Publikováno v: Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114098- (2023)

Cancer organoids generated from 3D in vitro cell cultures have contributed to the study of drug resistance. Maintenance of genomic and transcriptomic similarity between organoids and parental cancer allows organoids to have the ability of accurate pr

Externí odkaz: https://doaj.org/article/9257c0908fed499aa9fe40afb04edaf2

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Akademický článek

Added Value of Next Generation over Sanger Sequencing in Kenyan Youth with Extensive HIV-1 Drug Resistance

Autor: V. Novitsky, W. Nyandiko, R. Vreeman, A. K. DeLong, A. Manne, M. Scanlon, A. Ngeresa, J. Aluoch, F. Sang, C. Ashimosi, E. Jepkemboi, M. Orido, J. W. Hogan, R. Kantor

Publikováno v: Microbiology Spectrum, Vol 10, Iss 6 (2022)

ABSTRACT HIV-1 drug resistance testing in children and adolescents in low-resource settings is both important and challenging. New (more sensitive) drug resistance testing technologies may improve clinical care, but evaluation of their added value is

Externí odkaz: https://doaj.org/article/541f54134a7c462ba92ef37388b63bd3

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