Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB

Autor: Beibei eWang, Jingwei eWeng, Wenning eWang

Publikováno v: Frontiers in Microbiology, Vol 6 (2015)

The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymme

Externí odkaz: https://doaj.org/article/73392297255a483a862be3206e2e423c

Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance

Autor: Jessica Castro, Anna Vert, Marc Ribó, Antoni Benito, Maria Vilanova

Publikováno v: OncoTargets and therapy
OncoTargets and Therapy, 2018, vol. 11, p. 221-237
Articles publicats (D-B)
DUGiDocs – Universitat de Girona
instname
Recercat. Dipósit de la Recerca de Catalunya

Anna Vert1,2 Jessica Castro,1,2 Marc Ribó,1,2 Maria Vilanova,1,2 Antoni Benito1,2 1Protein Engineering Laboratory, Department of Biology, Faculty of Sciences, Universitat de Girona, 2Biomedical Research Institute of Girona (IDIBGi), Girona, Spain Ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c151c20f35c04e6d80d19be2bf399ede
http://europepmc.org/articles/PMC5757493

Regulation of ABCB1 activity by microRNA-200c and microRNA-203a in breast cancer cells: the quest for microRNAs’ involvement in cancer drug resistance

Autor: António Sebastião Rodrigues, José Rueff, Ana Armada, Miguel Viveiros, Bruno Gomes

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Aim: ABCB1 is a major player in cancer drug resistance. The purpose of this study was to functionally assess the regulation of ABCB1 activity in a doxorubicin-resistant breast cancer cell line by miR-200c and miR-203. Methods: Human breast carcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb2997880c5eb478db8f52fd42b092f
https://cdrjournal.com/article/view/3114

Microbial transport

Autor: Wil N. Konings

Publikováno v: Antonie Van Leeuwenhoek: International Journal of General and Molecular Microbiology, 90(4), 325-342. SPRINGER

The cytoplasmic membrane of bacteria is the matrix for metabolic energy transducing processes such as proton motive force generation and solute transport. Passive permeation of protons across the cytoplasmic membrane is a crucial determinant in the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554a4977cfa409b83ab0f9c47366f50e
https://doi.org/10.1007/s10482-006-9089-3

ydaG and ydbA of Lactococcus lactis Encode a Heterodimeric ATP-binding Cassette-type Multidrug Transporter

Autor: Jacek Lubelski, Wil N. Konings, Arnold J. M. Driessen, Ronald van Merkerk, Priotr Mazurkiewicz

Publikováno v: The Journal of Biological Chemistry, 279(33), 34449-34455. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Multidrug resistance (MDR)-type transporters mediate the active extrusion of structurally and functionally dissimilar compounds from the cells, thereby rendering cells resistant to a range of drugs. The ydaG and ydbA genes of Lactococcus lactis encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbf67180dc6367c107ff44eb102912d
https://doi.org/10.1074/jbc.m404072200