Zobrazeno 1 - 10
of 12
pro vyhledávání: '"drug effects [Synaptic Transmission]"'
Autor:
Yuko Fukata, Rosanna P. Sammons, Daniel Parthier, Masaki Fukata, Alexander B. Kowski, Dietmar Schmitz, Hans-Christian Kornau, Barbara Imbrosci, Jakob Kreye, Harald Prüss, Sarah Kurpjuweit, Alexander Stumpf
Publikováno v:
Annals of neurology 87(3), 405-418 (2020). doi:10.1002/ana.25666
Objective Leucine-rich glioma-inactivated 1 (LGI1) encephalitis is the second most common antibody-mediated encephalopathy, but insight into the intrathecal B-cell autoimmune response, including clonal relationships, isotype distribution, frequency,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0322489a49db8b9bb4adf18b8bed3fb8
https://doi.org/10.1002/ana.25666
https://doi.org/10.1002/ana.25666
Publikováno v:
Neuropharmacology 70, 287-295 (2013). doi:10.1016/j.neuropharm.2013.02.012
In search of a basis for the impressive potency of an endoprotease that cleaves SNAP-25, botulinum neurotoxin type A (BoNT/A), in treating numerous diseases due to hyper-active autonomic nerves, truncation of its target and inhibition of neurotransmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317a38f6ad08566639e25f14f4de7d13
https://doi.org/10.1016/j.neuropharm.2013.02.012
https://doi.org/10.1016/j.neuropharm.2013.02.012
Autor:
Marta Anglada-Huguet, Eva-Maria Mandelkow, Frank J.A. Dennissen, Astrid Sydow, Eckhard Mandelkow
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 113(41), 11597-11602 (2016). doi:10.1073/pnas.1603119113
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Accumulation of Tau is a characteristic hallmark of several neurodegenerative diseases but the mode of toxic action of Tau is poorly understood. Here, we show that the Tau protein is toxic due to its aggregation propensity, whereas phosphorylation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b52f81b47d2ed21ccae4ce84b6953bd
https://europepmc.org/articles/PMC5068267/
https://europepmc.org/articles/PMC5068267/
Autor:
Karl Deisseroth, Holger Dannenberg, Milan Pabst, Jurij Rosen, Albert J. Becker, Karen van Loo, Heinz Beck, Susanne Schoch, Leonie Pothmann, Wen Hu, Istvan Mody, Oliver Braganza
Publikováno v:
Neuron 90(4), 853-865 (2016). doi:10.1016/j.neuron.2016.04.003
The neurotransmitter acetylcholine, derived from the medial septum/diagonal band of Broca complex, has been accorded an important role in hippocampal learning and memory processes. However, the precise mechanisms whereby acetylcholine released from s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8c1e4be7006e5e0a7520da2be3d119
Autor:
Mark A. Hancock, Francois Charron, Dietmar Schmitz, Paul Dembny, Shireen Hossain, Peter W. Hildebrand, Yong Rao, Jürgen P. Rabe, Philip K.-Y. Chang, Heiko J. Bittner, Gerhard Multhaup, Rudi Lurz, Christian Barucker, Hunter Shaw, Wei Zhuang, Manuel Gensler, R. Anne McKinney, Anja Harmeier, Filip Liebsch, Scott A. Cameron
Publikováno v:
Scientific reports 5(1), 15410 (2015). doi:10.1038/srep15410
Scientific Reports
Scientific Reports
The amyloid-β42 (Aβ42) peptide is believed to be the main culprit in the pathogenesis of Alzheimer disease (AD), impairing synaptic function and initiating neuronal degeneration. Soluble Aβ42 oligomers are highly toxic and contribute to progressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae9f902bdd35b65429bb05722134bea
https://doi.org/10.1038/srep15410
https://doi.org/10.1038/srep15410
Autor:
Tursonjan Tokay, Timo Kirschstein, Mischa Uebachs, Katharina Klatte, Maria Kober, David M. Otte, Andreas Zimmer, Leonie Pothmann, Heinz Beck, Lorenz Müller
Publikováno v:
The journal of neuroscience 33(32), 13066-13080 (2013). doi:10.1523/JNEUROSCI.5423-12.2013
The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor. In many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617da5f98206b4f6836a014b943fbeb1
https://pub.dzne.de/record/137012
https://pub.dzne.de/record/137012
Publikováno v:
Do, An H; Wang, Po T; King, Christine E; Chun, Sophia N; & Nenadic, Zoran. (2013). Brain-computer interface controlled robotic gait orthosis. Journal of NeuroEngineering and Rehabilitation, 10(1), 111. doi: 10.1186/1743-0003-10-111. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3tc1s456
Journal of NeuroEngineering and Rehabilitation
Do, An H; Wang, Po T; King, Christine E; Chun, Sophia N; & Nenadic, Zoran. (2013). Brain-computer interface controlled robotic gait orthosis. Journal of NeuroEngineering and Rehabilitation, 10(1), 111. doi: http://dx.doi.org/10.1186/1743-0003-10-111. Retrieved from: http://www.escholarship.org/uc/item/830437jm
Journal of NeuroEngineering and Rehabilitation
Do, An H; Wang, Po T; King, Christine E; Chun, Sophia N; & Nenadic, Zoran. (2013). Brain-computer interface controlled robotic gait orthosis. Journal of NeuroEngineering and Rehabilitation, 10(1), 111. doi: http://dx.doi.org/10.1186/1743-0003-10-111. Retrieved from: http://www.escholarship.org/uc/item/830437jm
Reliance on wheelchairs after spinal cord injury (SCI) leads to many medical co-morbidities. Treatment of these conditions contributes to the majority of SCI health care costs. Restoring able-body-like ambulation after SCI may reduce the incidence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05daee543a6cb652dd8ba112d458e3b6
http://arxiv.org/abs/1208.5024
http://arxiv.org/abs/1208.5024
Publikováno v:
Neurotoxicology. 26(5)
There is considerable interest in understanding long-term potentiation (LTP) of glutamatergic synaptic transmission because the molecular mechanisms involved in its induction and expression are believed to be critical for learning and memory. There a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fb8296690ec0eba87ff1db6981f8c6
https://pubmed.ncbi.nlm.nih.gov/15939476
https://pubmed.ncbi.nlm.nih.gov/15939476
Autor:
Lee, Daewoo, O'Dowd, Diane K
Publikováno v:
Lee, Daewoo; & O'Dowd, Diane K. (1999). Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(13), 5311-5321. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3pf5h9wp
Difficulty in recording from single neurons in vivo has precluded functional analyses of transmission at central synapses in Drosophila, where the neurotransmitters and receptors mediating fast synaptic transmission have yet to be identified. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::43846abf2b12f9adb88a0506a5986f26
http://www.escholarship.org/uc/item/3pf5h9wp
http://www.escholarship.org/uc/item/3pf5h9wp
Publikováno v:
Neuroscience and biobehavioral reviews. 7(3)
The effects of intraventricular administration of neurotensin (0.9, 3.75 and 15.0 μg) on hyperactivity and stereotypy induced by either amphetamine (1 mg/kg), nomifensine (20 mg/kg), apomorphine (0.5 mg/kg) or N-n-propylnorapomorphine (0.5 mg/kg) we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d702e31cb7861b15b25a7e309395a2
https://pubmed.ncbi.nlm.nih.gov/6322065
https://pubmed.ncbi.nlm.nih.gov/6322065