Výsledky vyhledávání - "drug effects [Synapses]"

Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation

Autor: Philipp Ranft, Gaia Tavosanis, J. Scott Lauritzen, Lothar Baltruschat, André Fiala, Davi D. Bock, Luigi Prisco

Publikováno v: Cell Rep
Cell reports 34(11), 108871-(2021). doi:10.1016/j.celrep.2021.108871

The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad68944dcbe50a4fd6f766fc98c5473e
https://europepmc.org/articles/PMC8515896/

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In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons

Autor: Craig C. Garner, Johanna M. Montgomery, Kevin Lee, Yewon Jung, Yukti Vyas

Publikováno v: Molecular brain 14(1), 95 (2021). doi:10.1186/s13041-021-00809-3
Molecular Brain, Vol 14, Iss 1, Pp 1-6 (2021)
Molecular Brain

Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders characterised by deficits in social interactions and repetitive behaviours. ASDs have a strong genetic basis with mutations involved in the development and function of neural circuitry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5980e228c30198e983e8d4407b74af6c
https://pub.dzne.de/record/155437

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A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

Publikováno v: Science
Science, American Association for the Advancement of Science, 2020, 369 (6507), ⟨10.1126/science.abb4853⟩
Science / Science now 369(6507), eabb4853-(2020). doi:10.1126/science.abb4853

Synthetic excitatory synaptic organizer The human brain contains trillions of synapses within a vast network of neurons. Synapse remodeling is essential to ensure the efficient reception and integration of external stimuli and to store and retrieve i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58f31123378c66772e0ce9e75f687ac
https://hal.archives-ouvertes.fr/hal-03396266

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NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

Autor: Jakob von Engelhardt, Kenji Sakimura, Eric Jacobi, Michaela Kerstin Müller, Roberto Malinow

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications 6(1), 110 (2018). doi:10.1186/s40478-018-0611-4

Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid beta (Aβ)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18abc6835f7da525a487705c26d9d75e
http://link.springer.com/article/10.1186/s40478-018-0611-4

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P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

Autor: Andrea Delekate, Jan Peter, Jan N. Hansen, Nelli Blank, Björn Breithausen, Theresa Schulte, Armin Keller, Christian Henneberger, Monika Plescher, Kevin Keppler, Martin Fuhrmann, Gabor C. Petzold, Stefanie Poll, Nicole Reichenbach, Annett Halle

Publikováno v: Journal of Experimental Medicine
Journal of experimental medicine 215(6), 1649-1663 (2018). doi:10.1084/jem.20171487
The Journal of Experimental Medicine

Reichenbach et al. show that long-term P2Y1-receptor inhibition normalizes cerebral network dysfunction in an Alzheimer’s disease mouse model. This network recovery restores functional and structural synaptic integrity as well as learning and memor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab2c5fac7b220b9d1afd7388390c9f2
https://doi.org/10.1084/jem.20171487

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Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix

Autor: Grzegorz M. Wilczynski, Michal Stawarski, Katrin Böhm, Jakub Wlodarczyk, Malte Butzlaff, Jenny Schneeberg, Joanna Dzwonek, Dmitri A. Rusakov, Monika Bijata, Daria Guseva, Josephine Labus, Evgeni Ponimaskin, Alexander Dityatev, Piotr Michaluk

Publikováno v: Cell reports 19(9), 1767-1782 (2017). doi:10.1016/j.celrep.2017.05.023
Cell Reports, Vol 19, Iss 9, Pp 1767-1782 (2017)

Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, we mechanistically link these processes by uncovering a signaling pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597ac2764db0a060b4f2d960f95e96c1
https://doi.org/10.1016/j.celrep.2017.05.023

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Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength

Autor: Stefan Kindler, Charlotte J. Thynne, Craig C. Garner, Kevin Lee, Johanna M. Montgomery, Claudia Schob, Magali H. Arons, Sally A. Kim

Publikováno v: The journal of neuroscience 36(35), 9124-9134 (2016). doi:10.1523/JNEUROSCI.0116-16.2016

Shank3 is a multidomain scaffold protein localized to the postsynaptic density of excitatory synapses. Functional studies in vivo and in vitro support the concept that Shank3 is critical for synaptic plasticity and the trans-synaptic coupling between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aad45aa2a339038bd9f0a42ce5e83d
https://doi.org/10.1523/jneurosci.0116-16.2016

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Endogenous APP accumulates in synapses after BACE1 inhibition

Autor: Frauke Ackermann, Joshua A. Gregory, Shaohua Xu, Johan Lundkvist, Saket M. Nigam, Urban Lendahl, Lennart Brodin

Publikováno v: Neuroscience research 109, 9-15 (2016). doi:10.1016/j.neures.2016.02.002

BACE1-mediated cleavage of APP is a pivotal step in the production of the Alzheimer related Aβ peptide and inhibitors of BACE1 are currently in clinical development for the treatment of Alzheimer disease (AD). While processing and trafficking of APP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddaa00852bced7b4e296812d9ca45f9
https://doi.org/10.1016/j.neures.2016.02.002

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5-HT7 receptor shapes spinogenesis in cortical and striatal neurons: An Editorial Highlight for 'Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons'

Autor: Philippe Marin, Alexander Dityatev

Publikováno v: Journal of neurochemistry 141(5), 644-646 (2017). doi:10.1111/jnc.13981

Read the highlighted article 'Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons' on page 647.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147e8b954689bdc6dc93f66bad9541d
https://pubmed.ncbi.nlm.nih.gov/28122114

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Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability

Autor: Eva-Maria Mandelkow, Ram Reddy Chandupatla, Eckhard Mandelkow, Senthilvelrajan Kaniyappan

Publikováno v: Alzheimer's and dementia 13(11), 1270-1291 (2017). doi:10.1016/j.jalz.2017.04.002
Alzheimer's and Dementia

Introduction Tau-mediated toxicity in Alzheimer's disease is thought to operate through low-n oligomers, rather than filamentous aggregates. However, the nature of oligomers and pathways of toxicity are poorly understood. Therefore, we investigated s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5ce00fc9f4d7ea644ec94cc3f4ff58
https://pubmed.ncbi.nlm.nih.gov/28528849

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