AhR and IDO1 in pathogenesis of Covid-19 and the 'Systemic AhR Activation Syndrome:' a translational review and therapeutic perspectives

Autor: Waldemar A. Turski, Christopher A. Turski, Gabrielle N. Turski, Artur Wnorowski, Lechoslaw Turski

Publikováno v: Restorative neurology and neuroscience 38(4), 343-354 (2020). doi:10.3233/RNN-201042
Restorative Neurology and Neuroscience

Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as cough, fever, malaise, headache, and anosmia. After entry into cells, corona viruses (CoV) activate aryl hydrocarbon receptors (AhRs) by an indoleamine 2,3-diox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3305cf20deb1ef8c83dd4bc3021d1d
https://doi.org/10.3233/rnn-201042

Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides

Autor: Leah G. Helton, Panagiotis S Athanasopoulos, Bernd K Gilsbach, Scotty Hall, Ranjan Kumar Singh, Ahmed Soliman, Hardy J. Rideout, Felix von Zweydorf, Christian Johannes Gloeckner, Francesco Raimondi, Franz Y. Ho, Eileen J. Kennedy, Arjan Kortholt, Jascha Tobias Manschwetus, Timothy J LeClair, Friedrich W. Herberg, Wim Versées, Michalis Kentros

Publikováno v: ACS chemical biology 16(11), 2326-2338 (2021). doi:10.1021/acschembio.1c00487
ACS chemical biology, 16(11). AMER CHEMICAL SOC

Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and GTPase function that is commonly mutated in both familial and idiopathic Parkinson's Disease (PD). While dimerization of LRRK2 is commonly detected in PD models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37fc033b725a6992a27c05c3fcd9f95
https://doi.org/10.1021/acschembio.1c00487

The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4

Autor: Wolfgang Wurst, Thomas Ott, Kathrin Brockmann, Daniela Vogt-Weisenhorn, Andrea Wenninger-Weinzierl, Marita Munz, Ralf Kühn, Saskia Biskup, Florian Giesert, Natalja Funk, Thomas Gasser

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific reports 9(1), 4515 (2019). doi:10.1038/s41598-019-40808-y
Scientific Reports

Mutations within Leucine-rich repeat kinase 2 (LRRK2) are associated with late-onset Parkinson’s disease. The physiological function of LRRK2 and molecular mechanism underlying the pathogenic role of LRRK2 mutations remain uncertain. Here, we inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9ccd730fe7023ec1eb8e959bc4ec6f
http://link.springer.com/article/10.1038/s41598-019-40808-y

Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

Autor: Sven Korte, Benjamin Jurek, Dietmar Rudolf Thal, Florian Timo Ludwig, Sebastian A. Lewandowski, Tim-Henrik Bruun, Rosmarie Heydn, Inci Sevval Aksoylu, Joachim Weis, Andreas Hermann, Eva Wirkert, Heike Mrowetz, Barbara Altendorfer, Rodolphe Poupardin, Lars Mecklenburg, Sebastian Peters, Ohnmar Hsam, Siw Johannesen, Ulrich Bogdahn, Ludwig Aigner, Susanne Petri, Jochen H. Weishaupt, Sabrina Kuespert

Publikováno v: Neurotherapeutics 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Neurotherapeutics
Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2

Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Published by Springer, New York, NY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720507a761d33ae4f93f9fa50bdf546

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Autor: Jee Hyun Yi, Minee L. Choi, David Klenerman, Kwangwook Cho, Sonia Gandhi, Craig D. Hughes, Peter St George-Hyslop, Clare E. Bryant, Anna Drews, Seung Chan Kim

Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-7 (2020)
Communications biology 3(1), 79 (2020). doi:10.1038/s42003-020-0792-9
Hughes, C, Choi, M L, Yi, J H, Kim, S C, Drews, A, George-Hyslop, P S, Bryant, C, Gandhi, S, Cho, K & Klenerman, D 2020, ' Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death ', Communications Biology, vol. 3, 79 (2020) . https://doi.org/10.1038/s42003-020-0792-9

The molecular events causing memory loss and neuronal cell death in Alzheimer’s disease (AD) over time are still unknown. Here we found that picomolar concentrations of soluble oligomers of synthetic beta amyloid (Aβ42) aggregates incubated with B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2389ebda63d155ac45f2b0f4433b1cf5