Výsledky vyhledávání - "drug effects [Neurogenesis]"

The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression

Autor: Sónia Sá Santos, João B. Moreira, Márcia Costa, Rui S. Rodrigues, Ana M. Sebastião, Sara Xapelli, Susana Solá

Publikováno v: Cells, Vol 11, Iss 90, p 90 (2022)
Cells
Cells; Volume 11; Issue 1; Pages: 90
Cells 11(1), 90 (2021). doi:10.3390/cells11010090 special issue: "Mitochondrial Functions in Stem Cells"

Neural stem cells (NSCs), crucial for memory in the adult brain, are also pivotal to buffer depressive behavior. However, the mechanisms underlying the boost in NSC activity throughout life are still largely undiscovered. Here, we aimed to explore th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85349b7b18aeee155e366285a12d0ce
https://www.mdpi.com/2073-4409/11/1/90

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Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis

Autor: Martina Stazi, Sandra Lehmann, M. Sadman Sakib, Tonatiuh Pena-Centeno, Luca Büschgens, Andre Fischer, Sascha Weggen, Oliver Wirths

Publikováno v: Cellular and Molecular Life Sciences
Cellular and molecular life sciences 79(1), 55 (2021). doi:10.1007/s00018-021-04062-8

Epidemiological studies indicate that the consumption of caffeine, the most commonly ingested psychoactive substance found in coffee, tea or soft drinks, reduces the risk of developing Alzheimer’s disease (AD). Previous treatment studies with trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2f2df6abc62be2c342c4546e272e27
https://pubmed.ncbi.nlm.nih.gov/34913091

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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

Publikováno v: Neurotherapeutics 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Neurotherapeutics
Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2

Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Published by Springer, New York, NY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720507a761d33ae4f93f9fa50bdf546

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Apple Peel and Flesh Contain Pro-neurogenic Compounds

Autor: Jutta Ludwig-Müller, Tara L. Walker, Zeina Nicola, Merve Bulut, Gerd Kempermann, Alex M. Sykes, Leonardo Ortiz-López, Rupert W. Overall, Muhammad Ichwan, Vijay S. Adusumilli, Gerardo Ramírez-Rodríguez, Christoph Böttcher, Norbert Hubner, Enrique A. Lugo-Hernández

Publikováno v: Stem cell reports 16(3), 548-565 (2021). doi:10.1016/j.stemcr.2021.01.005
Stem Cell Reports

Summary As mammals evolved with exposure to particular diets, naturally abundant compounds may have become part of the set of environmental co-determinants that shaped brain structure and function. Here we investigated whether bioactive factors found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15b0ea64c8d6286e334014b640ae6b
https://pub.dzne.de/record/157719

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Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche

Autor: Mareike Fauser, Moritz D. Brandt, Christoph Redecker, Manfred Gerlach, Julia Müller, Grit Weselek, Silke Keiner, Alexander Storch, Barbara Kaltschmidt, Andreas Hermann, Lisa Wagenführ

Publikováno v: Stem cells 38(9), 1188–1201 (2020). doi:10.1002/stem.3232

The limited proliferative capacity of neuroprogenitor cells (NPCs) within the periventricular germinal niches (PGNs) located caudal of the subventricular zone (SVZ) of the lateral ventricles together with their high proliferation capacity after isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bdb3622839b7f3f271c955a5ab8d94
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/21825

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Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix

Autor: Grzegorz M. Wilczynski, Michal Stawarski, Katrin Böhm, Jakub Wlodarczyk, Malte Butzlaff, Jenny Schneeberg, Joanna Dzwonek, Dmitri A. Rusakov, Monika Bijata, Daria Guseva, Josephine Labus, Evgeni Ponimaskin, Alexander Dityatev, Piotr Michaluk

Publikováno v: Cell reports 19(9), 1767-1782 (2017). doi:10.1016/j.celrep.2017.05.023
Cell Reports, Vol 19, Iss 9, Pp 1767-1782 (2017)

Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, we mechanistically link these processes by uncovering a signaling pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597ac2764db0a060b4f2d960f95e96c1
https://doi.org/10.1016/j.celrep.2017.05.023

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A new dopaminergic nigro-olfactory projection

Autor: Vincent Ries, Günter U. Höglinger, Andreas Borta, Rainer K.W. Schwarting, Ursula Keber, Wolfgang H. Oertel, Dieter Scheller, Miriam Djufri, Oscar Arias-Carrión, Daniel Alvarez-Fischer, Andrea Windolph

Publikováno v: Acta neuropathologica 130(3), 333-348 (2015). doi:10.1007/s00401-015-1451-y

Parkinson disease (PD) is a neurodegenerative disorder characterized by massive loss of midbrain dopaminergic neurons. Whereas onset of motor impairments reflects a rather advanced stage of the disorder, hyposmia often marks the beginning of the dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42afd330dc60ddbf98fefbacc2ae706
https://doi.org/10.1007/s00401-015-1451-y

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Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain

Autor: Bhattarai, Prabesh, Thomas, Alvin Kuriakose, Cosacak, Mehmet Ilyas, Papadimitriou, Christos, Mashkaryan, Violeta, Zhang, Yixin, Kizil, Caghan

Publikováno v: JoVE journal Neuroscience(128), 56014 (2017). doi:10.3791/56014

Alzheimer's disease (AD) is a debilitating neurodegenerative disease in which accumulation of toxic amyloid-β42 (Aβ42) peptides leads to synaptic degeneration, inflammation, neuronal death, and learning deficits. Humans cannot regenerate lost neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b6fe9484d766b8376c64a998cc17d170
https://europepmc.org/articles/PMC5755241/

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Meis1: effects on motor phenotypes and the sensorimotor system in mice

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Disease models & mechanisms 10(8), 981-991 (2017). doi:10.1242/dmm.030080
Disease Models & Mechanisms, Vol 10, Iss 8, Pp 981-991 (2017)
Dis. Model. Mech. 10, 981-991 (2017)
Disease Models & Mechanisms

MEIS1 encodes a developmental transcription factor and has been linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and has a substantial impact on the quality of lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02d8a0c06ba30baead1d8b57a90f53d
http://hdl.handle.net/20.500.12105/6500

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Short- and long-term treatment with modafinil differentially affects adult hippocampal neurogenesis

Autor: A. Storch, E. Ellwardt, M.D. Brandt

Publikováno v: Neuroscience 278, 267-275 (2014). doi:10.1016/j.neuroscience.2014.08.014

The generation of new neurons in the dentate gyrus of the adult brain has been demonstrated in many species including humans and is suggested to have functional relevance for learning and memory. The wake promoting drug modafinil has popularly been c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ad0d3551b1ee6297fa397048381608
https://doi.org/10.1016/j.neuroscience.2014.08.014

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