Výsledky vyhledávání - "drug effects [MAP Kinase Signaling System]"

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

Autor: Sai-Yang Zhang, Yu-Hui Hou, Ping Li, Ying-Chao Liu, Cheng-Yun Jin, Ruo-Han Zhao, Hong-Min Liu, Xiaolin Zi, Ruo-Wang Mao, Dong-Jun Fu, Jia-Jia Yang, Jian Song, Yan-Bing Zhang, Zhang Li, Jia-Huan Li

Publikováno v: Fu, Dong-Jun; Zhang, Li; Song, Jian; Mao, Ruo-Wang; Zhao, Ruo-Han; Liu, Ying-Chao; et al.(2017). Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.. European journal of medicinal chemistry, 127, 87-99. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2jw7m037

A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC-109, PC-3). The first structure-activity relationship (SAR) for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c7cb2bc7ec5dbad4016e58ecc17c96
https://doi.org/10.1016/j.ejmech.2016.12.027

Zobrazit plný text záznamu

Selective Aptamer-Based Control of Intraneuronal Signaling

Autor: Heinz Beck, Sabine Lennarz, Therese Christine Alich, Günter Mayer, Michael Blind, Tony Kelly

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 54(18), 5369-5373 (2015). doi:10.1002/anie.201409597

Cellular behavior is orchestrated by the complex interactions of a myriad of intracellular signal transduction pathways. To understand and investigate the role of individual components in such signaling networks, the availability of specific inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d138105ed400cd4a1fb8cc5356c9fff
https://doi.org/10.1002/anie.201409597

Zobrazit plný text záznamu

Interplay between Obesity-Induced Inflammation and cGMP Signaling in White Adipose Tissue

Autor: Alexander Pfeifer, Jennifer Naumann, Andreas Schlitzer, Anna Ehrlund, Peter Arner, Abhishek Sanyal, Agnieszka Chabowska-Kita, Matthias Blüher, Linda S. Hoffmann

Publikováno v: Cell reports 18(1), 225-236 (2017). doi:10.1016/j.celrep.2016.12.028

Current worldwide figures suggest that obesity is pandemic. Understanding the underlying molecular mechanisms would help develop viable anti-obesity therapies. Here, we assess the influence of obesity-induced inflammation on white adipocyte cyclic gu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d6ddbc713dd79849d04a951af1a1f
https://pubmed.ncbi.nlm.nih.gov/28052251

Zobrazit plný text záznamu

CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling

Autor: Bernd Knöll, Sina Stern

Publikováno v: Molecular Brain
Molecular brain 7(1), 86 (2014). doi:10.1186/s13041-014-0086-6

Background CNS axon regeneration inhibitors such as Nogo and CSPGs (Chondroitin Sulfate Proteoglycans) are major extrinsic factors limiting outgrowth of severed nerve fibers. However, knowledge on intracellular signaling cascades and gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98897de2229ffd46096aff25f8d143da
http://europepmc.org/articles/PMC4243276

Zobrazit plný text záznamu

N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant

Autor: Ralf Kühn, Caroline Nothdurfter, Theo Rein, Rainer Rupprecht, Wolfgang Wurst, Barbara Di Benedetto

Publikováno v: Neuropharmacology 62(1), 209-216 (2012). doi:10.1016/j.neuropharm.2011.07.001

Quetiapine is an atypical antipsychotic which has been suggested to possess also antidepressant efficacy in the treatment of bipolar and unipolar depression. Recently, a link between the activation of the ERK/MAPK signalling pathway and the release o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738610c504eef86fb805c720c2bcf3b2
https://pub.dzne.de/record/136346

Zobrazit plný text záznamu

TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases

Autor: Chen, Gang, Khalil, Nasreen

Airway remodeling in asthma is the result of increased expression of connective tissue proteins, airway smooth muscle cell (ASMC) hyperplasia and hypertrophy. TGF-beta1 has been found to increase ASMC proliferation. The activation of mitogen-activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3292984704e03004fd3960a66d50a56f
https://escholarship.org/uc/item/0bx747fn

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání