Zobrazeno 1 - 6
of 6
pro vyhledávání: '"drug effects [Lysosomes]"'
Autor:
Eicke Latz, Victor Saavedra, Matthew Mangan, Anke Penno, Mario A. Lauterbach, Lars Kuerschner, Christoph Thiele
Publikováno v:
Autophagy
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity is described best b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7633b2425588b3dc8eb6ca3aa34a32
https://pubmed.ncbi.nlm.nih.gov/32835606
https://pubmed.ncbi.nlm.nih.gov/32835606
Autor:
Steven W.M. Olde Damink, Alena Grebe, Dieter Lütjohann, Tom Houben, Ronit Shiri-Sverdlov, Fons Verheyen, Nathalie Vaes, Sofie M. A. Walenbergh, Ger H. Koek, Eicke Latz, Patrick J. van Gorp, Tim Hendrikx, Mike L. J. Jeurissen
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 9, Pp 21056-21069 (2015)
International journal of molecular sciences, 16(9), 21056-21069. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 16
Issue 9
Pages 21056-21069
International journal of molecular sciences 16(9), 21056-21069 (2015). doi:10.3390/ijms160921056
International Journal of Molecular Sciences, Vol 16, Iss 9, Pp 21056-21069 (2015)
International journal of molecular sciences, 16(9), 21056-21069. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 16
Issue 9
Pages 21056-21069
International journal of molecular sciences 16(9), 21056-21069 (2015). doi:10.3390/ijms160921056
Recently, the importance of lysosomes in the context of the metabolic syndrome has received increased attention. Increased lysosomal cholesterol storage and cholesterol crystallization inside macrophages have been linked to several metabolic diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f005f8a6ec5d95f0da547c8f7ca01f
http://europepmc.org/articles/PMC4613241
http://europepmc.org/articles/PMC4613241
Autor:
Tine Holemans, Thorsten Pöppel, Matthis Synofzik, Christine Klein, Dae In Chang, Jean Samuel, Danny Mollerup Sørensen, Albena Jordanova, Dagmar Timmann, Bob Asselbergh, Shaun Martin, Ivailo Tournev, Jennifer Reichbauer, Teodora Chamova, Sarah van Veen, Ludger Schöls, Albena Andreeva, Alejandro Estrada-Cuzcano, Stephan Züchner, Rebecca Schüle, Peter Vangheluwe, Riet De Rycke
Publikováno v:
Brain 140(2), 287-305 (2017). doi:10.1093/brain/aww307
Brain
Brain
Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders characterized by progressive spasticity of the lower limbs due to degeneration of the corticospinal motor neurons. In a Bulgarian family with three siblings affected by comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4f6805d9040c3ac72308d892582147
https://pub.dzne.de/record/139142
https://pub.dzne.de/record/139142
Autor:
Inga Antyborzec, Valerie B. O'Leary, J. Oliver Dolly, Saak V. Ovsepian, Laszlo Zaborszky, Jochen Herms
Publikováno v:
Brain structure & function 219(5), 1527-1541 (2013). doi:10.1007/s00429-013-0583-x
A fascinating yet perhaps overlooked trait of the p75 neurotrophin receptor (p75(NTR)) is its ability to bind ligands with no obvious neurotrophic function. Using cultured basal forebrain (BF) neurons, this study demonstrates selective internalizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c0b743b2ba9c6e9d9b218209022c3c
https://doi.org/10.1007/s00429-013-0583-x
https://doi.org/10.1007/s00429-013-0583-x
Autor:
Adrian Danek, Alessandro Matte, Carlo Zancanaro, Lucia De Franceschi, Elena Tibaldi, Francesca Zonta, Benedikt Bader, Anna Maria Brunati, Seth L. Alper, Mariarita Bertoldi, Alok K. Sharma, Andreas Hermann, Ruth H. Walker, Alexander Storch, Francesca Lupo, Angela Siciliano, Donatella Benati
Publikováno v:
Blood 128(25), 2976-2987 (2016). doi:10.1182/blood-2016-07-727321
Chorea-acanthocytosis is one of the hereditary neurodegenerative disorders known as the neuroacanthocytoses. Chorea-acanthocytosis is characterized by circulating acanthocytes deficient in chorein, a protein of unknown function. We report here for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066e34dc3f3e1d101c1fb0f53a84d33d
Autor:
Diane Lucente, Stephen J. Haggarty, Uma Chandrachud, John F. Staropoli, Ronald G. Crystal, Hans R. Schöler, Kendrick A. Goss, Anton Petcherski, Dolan Sondhi, Steven D. Sheridan, Andreas Hermann, Susan L. Cotman, Xenia Lojewski, Sunita Biswas-Legrand, Martin K. Selig, Katherine B. Sims, James F. Gusella, Alexander Storch, Scott H. Coppel, Larissa Haliw, Jared Sterneckert, Peter Reinhardt, Alexandra M. Simas
Publikováno v:
Human molecular genetics 23(8), 2005-2022 (2013). doi:10.1093/hmg/ddt596
Neuronal ceroid lipofuscinosis (NCL) comprises ∼13 genetically distinct lysosomal disorders primarily affecting the central nervous system. Here we report successful reprograming of patient fibroblasts into induced pluripotent stem cells (iPSCs) fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d313bea46ea0728efda39427170896
https://pubmed.ncbi.nlm.nih.gov/24271013
https://pubmed.ncbi.nlm.nih.gov/24271013