Zobrazeno 1 - 10 of 12 pro vyhledávání: '"drug effects [Dendritic Spines]"'
1
Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons
Autor: Lisa Henkel, Karen Grütz, Anne Grünewald, Anna Kutschenko, Johanne Heine, Selma Staege, Andreas Hermann, Philip Seibler, Hannes Glaß, Norman Kalmbach, Florian Wegner, Thomas Gschwendtberger
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3565, p 3565 (2021)
International journal of molecular sciences 22(7), 3565 (2021). doi:10.3390/ijms22073565
Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efd60b20c5aaaf2112bf11ccfefbe65
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2
Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
Autor: Grzegorz M. Wilczynski, Michal Stawarski, Katrin Böhm, Jakub Wlodarczyk, Malte Butzlaff, Jenny Schneeberg, Joanna Dzwonek, Dmitri A. Rusakov, Monika Bijata, Daria Guseva, Josephine Labus, Evgeni Ponimaskin, Alexander Dityatev, Piotr Michaluk
Publikováno v: Cell reports 19(9), 1767-1782 (2017). doi:10.1016/j.celrep.2017.05.023
Cell Reports, Vol 19, Iss 9, Pp 1767-1782 (2017)
Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, we mechanistically link these processes by uncovering a signaling pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597ac2764db0a060b4f2d960f95e96c1
https://doi.org/10.1016/j.celrep.2017.05.023
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3
The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP)
Autor: Michael T. Heneka, Laura Haas, Jochen Herms, Franziska Seeser, Markus P. Kummer, Chris G. Parsons, Gerhard Rammes, Kaichuan Zhu, Korinna Mattusch
Publikováno v: Neuropharmacology 140, 184-192 (2018). doi:10.1016/j.neuropharm.2018.07.021
Aβ1-42 is well accepted to be a primary early pathogenic agent in Alzheimer's disease (AD). However, other amyloid peptides are now gaining considerable attention as potential key participants in AD due to their proposed higher neuronal toxicity. Im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ede97aa055511209c420904183444f
https://pubmed.ncbi.nlm.nih.gov/30016667
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4
Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function
Autor: Jochen Herms, Kaichuan Zhu, Severin Filser, Finn Peters
Publikováno v: Biological psychiatry 84(7), 478-487 (2018). doi:10.1016/j.biopsych.2018.04.022
Alzheimer's disease is the most prevalent neurodegenerative disorder among elderly persons. Overt accumulation and aggregation of the amyloid-β peptide (Aβ) is thought to be the initial causative factor for Alzheimer's disease. Aβ is produced by s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6620c8758e79b2103e9edb91b6f1f0b0
https://pubmed.ncbi.nlm.nih.gov/29945719
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5
5-HT7 receptor shapes spinogenesis in cortical and striatal neurons: An Editorial Highlight for 'Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons'
Autor: Philippe Marin, Alexander Dityatev
Publikováno v: Journal of neurochemistry 141(5), 644-646 (2017). doi:10.1111/jnc.13981
Read the highlighted article 'Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons' on page 647.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147e8b954689bdc6dc93f66bad9541d
https://pubmed.ncbi.nlm.nih.gov/28122114
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6
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability
Autor: Eva-Maria Mandelkow, Ram Reddy Chandupatla, Eckhard Mandelkow, Senthilvelrajan Kaniyappan
Publikováno v: Alzheimer's and dementia 13(11), 1270-1291 (2017). doi:10.1016/j.jalz.2017.04.002
Alzheimer's and Dementia
Introduction Tau-mediated toxicity in Alzheimer's disease is thought to operate through low-n oligomers, rather than filamentous aggregates. However, the nature of oligomers and pathways of toxicity are poorly understood. Therefore, we investigated s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5ce00fc9f4d7ea644ec94cc3f4ff58
https://pubmed.ncbi.nlm.nih.gov/28528849
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7
Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280
Autor: Marta Anglada-Huguet, Eva-Maria Mandelkow, Frank J.A. Dennissen, Astrid Sydow, Eckhard Mandelkow
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 113(41), 11597-11602 (2016). doi:10.1073/pnas.1603119113
Proceedings of the National Academy of Sciences of the United States of America
Accumulation of Tau is a characteristic hallmark of several neurodegenerative diseases but the mode of toxic action of Tau is poorly understood. Here, we show that the Tau protein is toxic due to its aggregation propensity, whereas phosphorylation an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b52f81b47d2ed21ccae4ce84b6953bd
https://europepmc.org/articles/PMC5068267/
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8
Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions
Autor: Mercè Masana, Marianne B. Müller, Christian K.E. Jung, Lidia Blazquez-Llorca, Christiane Volbracht, Anders Brandt Elvang, Saak V. Ovsepian, Jochen Herms, Severin Filser
Publikováno v: Biological psychiatry 77(8), 729-739 (2015). doi:10.1016/j.biopsych.2014.10.013
Background BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate limiting protease in amyloid β production, hence a promising drug target for the treatment of Alzheimer's disease. Inhibition of BACE1, as the major β-secretase in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb421afb016d5a65583de63e68321280
https://pub.dzne.de/record/137858
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9
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers
Autor: Thomas Koeglsperger, Dennis J. Selkoe, Ming Jin, Ting Yang, Hongjun Fu, Shaomin Li, Dainan Zhang
Publikováno v: Neuron 77(5), 929-941 (2013). doi:10.1016/j.neuron.2012.12.040
SummaryA central question about human brain aging is whether cognitive enrichment slows the development of Alzheimer changes. Here, we show that prolonged exposure to an enriched environment (EE) facilitated signaling in the hippocampus of wild-type
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda3bb10a51c75b56b7efb5bfcc78996
https://pub.dzne.de/record/136838
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10
Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton
Autor: Eva-Maria Mandelkow, Hans Zempel
Publikováno v: Neurodegenerative diseases 10(1-4), 64-72 (2012). doi:10.1159/000332816
Neurodegenerative Diseases
Background: In Alzheimer’s disease (AD), amyloid-β (Aβ) is the major component of extracellular plaques, whereas the microtubule-associated protein tau forms the main component of intracellular tangles. In contrast to frontotemporal dementias and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf637e835e667b86b80e06e375441e2
https://pubmed.ncbi.nlm.nih.gov/22156588
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