Výsledky vyhledávání - "drug effects [Cognition]"

Lack of association between proton pump inhibitor use and brain aging: a cross-sectional study

Autor: Jakob Linseisen, Katharina Wittfeld, Christa Meisinger, Ute Amann, Ulf Schminke, Henry Völzke, Hans J. Grabe, Robin Bülow, Markus M. Lerch, Ina-Maria Rückert-Eheberg, Stefan Frenzel, Jean-François Chenot, Sebastian E. Baumeister, Michael Nolde, Nayeon Ahn

Publikováno v: European journal of clinical pharmacology 77(7), 1039-1048 (2021). doi:10.1007/s00228-020-03068-8
European Journal of Clinical Pharmacology
Eur. J. Clin. Pharmacol. 77, 1039-1048 (2021)

PurposeDue to conflicting scientific evidence for an increased risk of dementia by intake of proton pump inhibitors (PPIs), this study investigates associations between PPI use and brain volumes, estimated brain age, and cognitive function in the gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e76cd873ed72062a644d02be8e83d9
https://pub.dzne.de/record/155752

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P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

Autor: Andrea Delekate, Jan Peter, Jan N. Hansen, Nelli Blank, Björn Breithausen, Theresa Schulte, Armin Keller, Christian Henneberger, Monika Plescher, Kevin Keppler, Martin Fuhrmann, Gabor C. Petzold, Stefanie Poll, Nicole Reichenbach, Annett Halle

Publikováno v: Journal of Experimental Medicine
Journal of experimental medicine 215(6), 1649-1663 (2018). doi:10.1084/jem.20171487
The Journal of Experimental Medicine

Reichenbach et al. show that long-term P2Y1-receptor inhibition normalizes cerebral network dysfunction in an Alzheimer’s disease mouse model. This network recovery restores functional and structural synaptic integrity as well as learning and memor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab2c5fac7b220b9d1afd7388390c9f2
https://doi.org/10.1084/jem.20171487

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Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome

Autor: Craig C. Garner, Damien Colas, Bayarsaikhan Chuluun, H. Craig Heller

Publikováno v: Neurobiology of learning and memory 140, 11-16 (2017). doi:10.1016/j.nlm.2017.02.006

Down syndrome (DS) is a common genetic cause of intellectual disability yet no pro-cognitive drug therapies are approved for human use. Mechanistic studies in a mouse model of DS (Ts65Dn mice) demonstrate that impaired cognitive function is due to ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a121606a47e79f02887c069f6fa4c592
https://doi.org/10.1016/j.nlm.2017.02.006

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Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial

Autor: Wirth, Miranka, Schwarz, Claudia, Märschenz, Stefanie, Mai, Knut, Kopp, Ute, Schmitz, Dietmar, Grittner, Ulrike, Sigrist, Stephan J, Stekovic, Slaven, Madeo, Frank, Flöel, Agnes, Benson, Gloria, Horn, Nora, Buchert, Ralph, Lange, Catharina, Köbe, Theresa, Hetzer, Stefan, Maglione, Marta, Michael, Eva

Publikováno v: Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2019)
Alzheimer's research & therapy 11(1), 36 (2019). doi:10.1186/s13195-019-0484-1

Background Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues. This trial aims to contribute to the establishment of effective approaches to promo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b65e1289ecd46018c85e058fdbc3112
http://europepmc.org/articles/PMC6492385

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Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience

Autor: Hadar, Ravit, Edemann-Callesen, Henriette, Hlusicka, Elizabeth Barroeta, Wieske, Franziska, Vogel, Martin, Günther, Lydia, Vollmayr, Barbara, Hellweg, Rainer, Heinz, Andreas, Garthe, Alexander, Winter, Christine

Publikováno v: Translational Psychiatry 9(1), 185 (2019). doi:10.1038/s41398-019-0523-5
Translational Psychiatry, Vol 9, Iss 1, Pp 1-9 (2019)
Translational Psychiatry

Depressive symptoms are often accompanied by cognitive impairments and recurrent depressive episodes are discussed as a potential risk for dementia. Especially, stressful life events are considered a potent risk factor for depression. Here, we induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744ceca4957db1923eb09145be07bec0
https://pub.dzne.de/record/140866

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TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

Autor: Hugo Balleza-Tapia, André Fisahn, Gefei Chen, Sophie Crux, Yuniesky Andrade-Talavera, Daniela Papadia, Jan Johansson, Pablo Dolz-Gaitón

Publikováno v: eLife 7, e37703 (2018). doi:10.7554/eLife.37703
eLife, Vol 7 (2018)
eLife

Amyloid-β peptide (Aβ) forms plaques in Alzheimer’s disease (AD) and is responsible for early cognitive deficits in AD patients. Advancing cognitive decline is accompanied by progressive impairment of cognition-relevant EEG patterns such as gamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce47602eb69dfb0497d2ddf57594056
https://pub.dzne.de/record/140364

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Treatment during a vulnerable developmental period rescues a genetic epilepsy

Autor: Anton Ivanov, Vu Thao Quyen Le-Schulte, Christophe Bernard, Fabio Morellini, Ronny Eichler, Axel Neu, Stephan Lawrence Marguet, Igor Jakovcevski, Ileana L. Hanganu-Opatz, Dirk Isbrandt, Andrea Merseburg

Publikováno v: Nature medicine 21(12), 1436-1444 (2015). doi:10.1038/nm.3987

The nervous system is vulnerable to perturbations during specific developmental periods. Insults during such susceptible time windows can have long-term consequences, including the development of neurological diseases such as epilepsy. Here we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99de2fcb9965b9b6f993ba22f2b06d6b
https://doi.org/10.1038/nm.3987

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7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway

Autor: Josep-Maria Canals, Nuria Gaja-Capdevila, Jordi Soriano, Albert Giralt, Jordi Alberch, Gerardo García-Díaz Barriga, Marta Anglada-Huguet, Javier G. Orlandi

Publikováno v: Human Molecular Genetics
Human molecular genetics 26(16), 3144 – 3160 (2017). doi:10.1093/hmg/ddx198

Huntington's disease (HD) is a fatal neurodegenerative disease with motor, cognitive and psychiatric impairment. Dysfunctions in HD models have been related to reduced levels of striatal brain-derived neurotrophic factor (BDNF) and imbalance between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcb77c9b09038a2e2b5b9f3a2400b58
https://doi.org/10.1093/hmg/ddx198

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PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

Autor: Angelika Griep, Mitsugu Yamanaka, Daisy Axt, Markus P. Kummer, Michael T. Heneka, Taizo Ishikawa

Publikováno v: The journal of neuroscience 32(48), 17321-17331 (2012). doi:10.1523/JNEUROSCI.1569-12.2012

Alzheimer's disease (AD) is characterized by the extracellular deposition of amyloid-β (Aβ), neurofibrillary tangle formation, and a microglial-driven inflammatory response. Chronic inflammatory activation compromises microglial clearance functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fc1816b1f52c0ea11afb0eff7e97ed
https://doi.org/10.1523/jneurosci.1569-12.2012

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Oxytocin enhances cognitive control of food craving in women

Autor: Striepens, Nadine, Schröter, Franziska, Stoffel-Wagner, Birgit, Maier, Wolfgang, Hurlemann, René, Scheele, Dirk

Publikováno v: Hum Brain Mapp
Human brain mapping 37(12), 4276-4285 (2016). doi:10.1002/hbm.23308

In developed countries, obesity has become an epidemic resulting in enormous health care costs for society and serious medical complications for individuals. The homeostatic regulation of food intake is critically dependent on top-down control of rew

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c6c45a5243cad9888f11ad4085623a2
https://pubmed.ncbi.nlm.nih.gov/27381253

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