AKT1 E17K ‐mutated meningioma cell lines respond to treatment with the AKT inhibitor AZD5363

Autor: Stefan Schnabel, Christian Mawrin, Felix Sahm, Natalie Waldt, Christoph Kesseler, Josephine Liebich, Peter John, C. Scherlach, Frank Angenstein, I. Erol Sandalcioglu, Elmar Kirches

Publikováno v: Neuropathology & applied neurobiology 48(2), e12780 (2022). doi:10.1111/nan.12780

Objectives Meningiomas are the most frequent primary brain tumours. Recently, knowledge about the molecular drivers underlying aggressive meningiomas has been expanded. A hotspot mutation in the AKT1 gene (AKT1E17K ), which is found in meningiomas at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cca490852d8aecdd9a5e8a3886f1d3a
https://doi.org/10.1111/nan.12780

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

Autor: S Cantilena, Stefanie Meier, Darren Hargrave, David Michod, John Anderson, Jasper de Boer, Maria Victoria Niklison Chirou, Paolo Salomoni

Publikováno v: Cell Death & Disease
Cell death & disease 12(8), 785 (2021). doi:10.1038/s41419-021-04078-9
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)

Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However, the treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352d109b5f0dbec2fa754da507bbd703
https://pubmed.ncbi.nlm.nih.gov/34381018

Apple Peel and Flesh Contain Pro-neurogenic Compounds

Autor: Jutta Ludwig-Müller, Tara L. Walker, Zeina Nicola, Merve Bulut, Gerd Kempermann, Alex M. Sykes, Leonardo Ortiz-López, Rupert W. Overall, Muhammad Ichwan, Vijay S. Adusumilli, Gerardo Ramírez-Rodríguez, Christoph Böttcher, Norbert Hubner, Enrique A. Lugo-Hernández

Publikováno v: Stem cell reports 16(3), 548-565 (2021). doi:10.1016/j.stemcr.2021.01.005
Stem Cell Reports

Summary As mammals evolved with exposure to particular diets, naturally abundant compounds may have become part of the set of environmental co-determinants that shaped brain structure and function. Here we investigated whether bioactive factors found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15b0ea64c8d6286e334014b640ae6b
https://pub.dzne.de/record/157719

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

Autor: Sai-Yang Zhang, Yu-Hui Hou, Ping Li, Ying-Chao Liu, Cheng-Yun Jin, Ruo-Han Zhao, Hong-Min Liu, Xiaolin Zi, Ruo-Wang Mao, Dong-Jun Fu, Jia-Jia Yang, Jian Song, Yan-Bing Zhang, Zhang Li, Jia-Huan Li

Publikováno v: Fu, Dong-Jun; Zhang, Li; Song, Jian; Mao, Ruo-Wang; Zhao, Ruo-Han; Liu, Ying-Chao; et al.(2017). Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.. European journal of medicinal chemistry, 127, 87-99. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2jw7m037

A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC-109, PC-3). The first structure-activity relationship (SAR) for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c7cb2bc7ec5dbad4016e58ecc17c96
https://doi.org/10.1016/j.ejmech.2016.12.027

Calcium, Sodium, and Transient Receptor Potential Channel Expression in Human Fetal Midbrain-Derived Neural Progenitor Cells

Autor: Salini Tharmarasa, Florian Wegner, Martin Klietz, Selma Staege, Sigrid C. Schwarz, Nancy Stanslowsky, Norman Kalmbach, Andreas Leffler

Publikováno v: Stem Cells and Development 27(14), 976-984 (2018). doi:10.1089/scd.2017.0281

Voltage-gated sodium and calcium channels as well as transient receptor potential (TRP) channels are expressed during the differentiation of human neural progenitor cells (hNPCs) and are likely to be involved in regulating neurogenesis. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02211f2b333603036b593e10ee63fb3
https://pubmed.ncbi.nlm.nih.gov/29779467