Zobrazeno 1 - 10
of 16
pro vyhledávání: '"drug effects [Cell Membrane]"'
Autor:
Zohreh Hosseinzadeh, Stefanie Schuster, Yogesh Singh, Nefeli Zacharopoulou, Philip Höflinger, Ludger Schöls, Christos Stournaras, Florian Lang, Lisann Pelzl, Yamini Sharma, Stefan Hauser, Eberhart Zrenner, Daniel Rathbun
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports 10(1), 8391 (2020). doi:10.1038/s41598-020-64845-0
Scientific reports 10(1), 8391 (2020). doi:10.1038/s41598-020-64845-0
Loss of function mutations of the chorein-encoding gene VPS13A lead to chorea-acanthocytosis (ChAc), a neurodegenerative disorder with accelerated suicidal neuronal cell death, which could be reversed by lithium. Chorein upregulates the serum and glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78376c4b2009a2cf3944bfb257b95e7
http://link.springer.com/article/10.1038/s41598-020-64845-0
http://link.springer.com/article/10.1038/s41598-020-64845-0
Autor:
Stefan F. Lichtenthaler, Shanshan Sun, Jian Huang, Chen Cheng, Wei-Shuo Fang, Ying-Hong Wang, Katrin Moschke, Shuang Yang, Deyang Sun, Tianqi Li
Publikováno v:
Bioorganic chemistry 92, 103253 (2019). doi:10.1016/j.bioorg.2019.103253
Two β-secreatase (BACE1) inhibitors from natural products (cinnamic acid and flavone) were linked to furnish potent, cell permeable BACE1 inhibitors with noncompetitive mode of inhibition, with the assistance of saturated transfer difference (STD)-N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87706b9b7ac457762e8317189ae9c3c6
Autor:
Kanako Higuchi, Atsutoshi Yoshimura, Yoshitaka Hara, Takashi Kaneko, S.M. Ziauddin, Eicke Latz, J. L. Montenegro Raudales, Yukio Ozaki, Takashi Ukai, Toshihiro Miyazaki
Publikováno v:
Journal of periodontal research 53(3), 353-361 (2017). doi:10.1111/jre.12520
Background and objective Dental calculus is a mineralized deposit attached to the tooth surface. We have shown that cellular uptake of dental calculus triggers nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db79f577785a38dbf556eaf080d0fa8
https://pub.dzne.de/record/139944
https://pub.dzne.de/record/139944
Autor:
Stefan F. Lichtenthaler, Qing-Xiang Amy Sang, Taheera Ferdous, Robert M. Petrovich, Bart De Strooper, Marcia L. Moss, Ina Tesseur, Gary Powell, Colin Dingwall, Jörg W. Bartsch, Bin Qi, Douglas A. Lauffenburger, Julia Li Zhong, Uwe Schlomann, Linda G. Griffith, Miles A. Miller, Mara Taverna, Lori L. Edwards, Pei Zhou
Publikováno v:
American Society for Biochemistry and Molecular Biology
The journal of biological chemistry 286(47), 40443-40451 (2011). doi:10.1074/jbc.M111.280495
The journal of biological chemistry 286(47), 40443-40451 (2011). doi:10.1074/jbc.M111.280495
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f46250ec6dfd62cdd977af30f72776
http://hdl.handle.net/1721.1/76196
http://hdl.handle.net/1721.1/76196
Autor:
Valentina Ruiz-Gutiérrez, Jesús Prades, Sérgio S. Funari, Francisca Barceló, Oliver Vögler, Regina Alemany, Manuel Gómez-Florit
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochimica et biophysica acta / Biomembranes 1808, 752-760 (2011). doi:10.1016/j.bbamem.2010.12.007
instname
Biochimica et biophysica acta / Biomembranes 1808, 752-760 (2011). doi:10.1016/j.bbamem.2010.12.007
Free triterpenic acids (TTPs) present in plants are bioactive compounds exhibiting multiple nutriceutical activities. The underlying molecular mechanisms have only been examined in part and mainly focused on anti-inflammatory properties, cancer and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419b2e903bef9396b0b00c54431b3ee9
http://hdl.handle.net/10261/53728
http://hdl.handle.net/10261/53728
Autor:
Stefan Mitterreiter, Martina Malnar, Damir Omerbašić, Marko Kosicek, Silva Hećimović, Stefan F. Lichtenthaler, Alison Goate
Publikováno v:
Biochimica et biophysica acta / Molecular basis of disease 1802(7-8), 682-691 (2010). doi:10.1016/j.bbadis.2010.05.006
Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2010, 1802 (7-8), pp.682. ⟨10.1016/j.bbadis.2010.05.006⟩
Biochimica et biophysica acta : molecular basis of diseas
Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2010, 1802 (7-8), pp.682. ⟨10.1016/j.bbadis.2010.05.006⟩
Biochimica et biophysica acta : molecular basis of diseas
The link between cholesterol and Alzheimer's disease has recently been revealed in Niemann-Pick type C disease. We found that NPC1(-/-) cells show decreased expression of APP at the cell surface and increased processing of APP through the beta-secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2f6727d7dfbb240364d39e68b5ca47
Autor:
Schromm, A. B., Howe, J., Ulmer, A. J., Wiesmüller, K. H., Seyberth, T., Jung, G., Rössle, M., Koch, M. H. J., Gutsmann, T., Brandenburg, K.
Publikováno v:
The journal of biological chemistry 282, 11030-11037 (2007). doi:10.1074/jbc.M700287200
The importance of the biological function and activity of lipoproteins from the outer or cytoplasmic membranes of Gram-positive and Gram-negative bacteria is being increasingly recognized. It is well established that they are like the endotoxins (lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86a53e1c64e4fbd25172ba175f28ac1f
https://pubmed.ncbi.nlm.nih.gov/17308304
https://pubmed.ncbi.nlm.nih.gov/17308304
Autor:
J. D. Ostrow, J E Bayon, Pasupati Mukerjee, Lorella Pascolo, Claudio Tiribelli, Ronald Koehler, Cecile Webster, S. Del Vecchio
Publikováno v:
The Biochemical journal. 316
Using highly purified unconjugated [3H]bilirubin (UCB), we measured UCB binding to delipidated human serum albumin (HSA) and its uptake by basolateral rat liver plasma membrane vesicles, in both the absence and presence of an inside-positive membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71f9c535af23a84a09fab236218cfea
https://pubmed.ncbi.nlm.nih.gov/9003429
https://pubmed.ncbi.nlm.nih.gov/9003429
Autor:
Riccardo Candido, Maria Rosa Cattin, Louise M Burrell, Mary Artero, Bruno Fabris, Moreno Bardelli, Francesco Fior, Faccini L, Belinda J Davis, Renzo Carretta, Michele Carraro, Cristina Zennaro
BACKGROUND: The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS). METHODS: Five groups, 10 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1732d5f119fcce758ce60a700f03f412
http://hdl.handle.net/11368/2360745
http://hdl.handle.net/11368/2360745
Autor:
Vincenzo Sorrentino, Fioretta Palombi, Antonio Conti, Elio Ziparo, Antony Galione, Grant C. Churchill, Antonio Filippini, Armando A. Genazzani, Fortunata Barone
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16(7)
cADPR, a potent calcium-mobilizing intracellular messenger synthesized by ADP-ribosyl cyclases regulates openings of ryanodine receptors (RyR). Here we report that in the rat testis, a functional cADPR Ca2+ release system is essential for the contrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d017c6fb4a1bfe30b95c67f09bf9d839
http://ora.ox.ac.uk/objects/uuid:5ae72232-2acf-4d6a-85af-db8bd62314c0
http://ora.ox.ac.uk/objects/uuid:5ae72232-2acf-4d6a-85af-db8bd62314c0