Výsledky vyhledávání - "drug effects [Amyloid beta-Peptides]"

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model

Autor: Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach

Publikováno v: Journal of neuroinflammation 19, 172 (2022). doi:10.1186/s12974-022-02534-7

Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been identified as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cf79aae6780bc19a3e061b1136211f
http://edoc.mdc-berlin.de/21752/2/21752suppl.zip

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Aβ seeds resist inactivation by formaldehyde

Autor: Lary C. Walker, Jasmin Mahler, Mathias Jucker, Manuela Neumann, K. Peter R. Nilsson, Amarallys F. Cintron, Sarah K. Fritschi, Per Hammarström, Anika Bühler, Lan Ye, Frank Baumann

Publikováno v: Acta neuropathologica 128(4), 477-484 (2014). doi:10.1007/s00401-014-1339-2

Cerebral β-amyloidosis can be exogenously induced by the intracerebral injection of brain extracts containing aggregated β-amyloid (Aβ) into young, pre-depositing Aβ precursor protein- (APP) transgenic mice. Previous work has shown that the induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0efb8ca8ebc44dd5ce70616b1d5326
https://pub.dzne.de/record/137547

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Attenuated Aβ42 Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds*

Autor: Guido Galley, Amelie Gutsmiedl, Karlheinz Baumann, Benedikt Kretner, Akio Fukumori, Thomas Luebbers, Richard M. Page, Harald Steiner, Christian Haass

Publikováno v: The journal of biological chemistry 286(17), 15240-15251 (2011). doi:10.1074/jbc.M110.213587

Sequential processing of the β-amyloid precursor protein by β- and γ-secretase generates the amyloid β-peptide (Aβ), which is widely believed to play a causative role in Alzheimer disease. Selective lowering of the pathogenic 42-amino acid varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eea2c1ae3195c97857d3a447f67e199
https://europepmc.org/articles/PMC3083200/

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Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer’s disease

Autor: Aleksandra Szybinska, Armin Giese, Franz Bracher, Jacek Kuznicki, André P. Gehring, Kamran Honarnejad, A Daschner, Jochen Herms

Publikováno v: Translational Psychiatry
Translational Psychiatry 4(12), e489-e489 (2014). doi:10.1038/tp.2014.132

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder and the most frequent cause of dementia. To date, there are only a few approved drugs for AD, which show little or no effect on disease progression. Impaired intracellular c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05728660fd18ba897b0b3d92955f09b4
https://doi.org/10.1038/tp.2014.132

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