Výsledky vyhledávání - "drug effects [Amyloid Precursor Protein Secretases]"

Attenuated Aβ42 Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds*

Autor: Guido Galley, Amelie Gutsmiedl, Karlheinz Baumann, Benedikt Kretner, Akio Fukumori, Thomas Luebbers, Richard M. Page, Harald Steiner, Christian Haass

Publikováno v: The journal of biological chemistry 286(17), 15240-15251 (2011). doi:10.1074/jbc.M110.213587

Sequential processing of the β-amyloid precursor protein by β- and γ-secretase generates the amyloid β-peptide (Aβ), which is widely believed to play a causative role in Alzheimer disease. Selective lowering of the pathogenic 42-amino acid varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eea2c1ae3195c97857d3a447f67e199
https://europepmc.org/articles/PMC3083200/

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