Zobrazeno 1 - 2
of 2
pro vyhledávání: '"drug effects/physiology, Protein Subunits"'
Autor:
David Bleakman, Nigel P. Dolman, Samantha Jack, David E Jane, Richard M. Morley, Julia C. A. More, Andrew Alt, Zuner A. Bortolotto, Robert Nisticò, Peter J. Roberts, Helen M Troop, Jody L. Knauss, Graham L. Collingridge
Publikováno v:
Journal of medicinal chemistry. 48(24)
The natural product willardiine (8) is an AMPA receptor agonist while 5-iodowillardiine (10) is a selective kainate receptor agonist. In an attempt to produce antagonists of kainate and AMPA receptors analogues of willardiine with substituents at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251754fe7ba85f935de7c0d98faf024f
https://pubmed.ncbi.nlm.nih.gov/16302825
https://pubmed.ncbi.nlm.nih.gov/16302825
Autor:
Julia C. A. More, Ann Marie L. Ogden, David E. Jane, Vernon R. J. Clarke, Zuner A. Bortolotto, Nigel P. Dolman, Fabio Pilato, Robert Nisticò, Andrew Alt, David Bleakman, Floris P. Buelens, Graham L. Collingridge, Helen M Troop, Eve E. Kelland
Willardiine derivatives with an N3-benzyl substituent bearing an acidic group have been synthesized with the aim of producing selective antagonists for GLUK5-containing kainate receptors. UBP296 was found to be a potent and selective antagonist of na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3f707d8a6a5ef58f76157c818b83e0
http://hdl.handle.net/11573/514325
http://hdl.handle.net/11573/514325
