Zobrazeno 1 - 10
of 21
pro vyhledávání: '"drug effects/metabolism/physiopathology"'
Autor:
Marcello D'Amelio, Nicola Berretta, Robert Nisticò, Annalisa Nobili, Nicola Biagio Mercuri, Virve Cavallucci
Publikováno v:
NeuroMolecular Medicine. 15:541-548
Functional and ultrastructural investigations support the concept that altered brain connectivity, exhausted neural plasticity, and synaptic loss are the strongest correlates of cognitive decline in age-related neurodegenerative dementia of Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6012782324148446316e7085a5c8725
https://doi.org/10.1007/s12017-013-8241-2
https://doi.org/10.1007/s12017-013-8241-2
Autor:
Fabrizio Montecucco, Rubén D. Sinisterra, Daniele da Silva, François Mach, Rafaela F. da Silva, Rodrigo A. Fraga-Silva, Silvia Q Savergnini, Robson A.S. Santos, Frederico B. De Sousa, Fabiana P. Costa-Fraga, Nikolaos Stergiopulos
Publikováno v:
The journal of sexual medicine
Journal of Sexual Medicine, Vol. 10, No 10 (2013) pp. 2430-2442
Journal of Sexual Medicine, Vol. 10, No 10 (2013) pp. 2430-2442
Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin‐II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin‐(1‐7) (Ang‐[1‐7])
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9895192e672fab0c908f87d85eea6dd
Autor:
Kotaro Takasaki, Izzettin Hatip-Al-Khatib, Kaori Kubota, Katsunori Iwasaki, Funda F. Bölükbaşı Hatip, Risako Fujikawa, Ai Nogami-Hara, Nobuaki Egashira, Shutaro Katsurabayashi, Takuya Watanabe, Masaki Nagao
Ethnopharmacological relevance Japanese Angelica acutiloba root (Angelica root) is included in several Kampo medicines including Yokukansan (YKS). Angelica root and YKS are used for the treatment of a variety of psychological and neurodegenerative di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3771c8d5ca96911db18dd35a2c655c05
https://doi.org/10.1016/j.jep.2017.12.025
https://doi.org/10.1016/j.jep.2017.12.025
Publikováno v:
Behavioural Brain Research. 161:45-59
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in rats that resembles some of the symptoms of endogenous depression in humans. In the present study, CMS-induced behavioural responses along with neurochemical alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7f4f94377fab39f7c13ce2121cd149
https://doi.org/10.1016/j.bbr.2005.01.005
https://doi.org/10.1016/j.bbr.2005.01.005
Autor:
Alberto Gulino, Silvia Rossi, Maddalena Napolitano, Giorgio Bernardi, Stefania Spiezia, Paolo Gubellini, Paolo Calabresi, Diego Centonze
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 2, Pp 407-414 (2004)
Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by motor abnormalities and cognitive impairment. The irreversible succinate dehydrogenase (SD) inhibitor 3-nitropropionic acid (3NP) causes neurodegeration in the striatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230e441fcdf3a911507efc1cbaa9462c
https://doi.org/10.1016/j.nbd.2003.11.021
https://doi.org/10.1016/j.nbd.2003.11.021
Autor:
Emanuela Esposito, Daniela Impellizzeri, Rosanna Di Paola, Emanuela Mazzon, Placido Bramanti, Salvatore Cuzzocrea
Olprinone is a specific phosphodiesterase (PDE)-III inhibitor, which has been found to have anti-inflammatory effects in addition to its main inotropic and peripheral vasodilatory effects. In the present study we investigated the effects of olprinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f0dd39297d256415e40674bdb98aa8
http://hdl.handle.net/11570/1916435
http://hdl.handle.net/11570/1916435
Autor:
Vincenzo Cimini, Amelia Filippelli, Guido Iaccarino, Massimo Marchese, Gianfranco Matrone, Carmela Zincarelli, Gennaro Galasso, Luca Golino, Giuseppe Rengo, Francesca Fortunato, Nicola Ferrara, Emma Sanzari, Walter J. Koch, Michele Ciccarelli, Franco Rengo, Giovanna Giuseppina Altobelli, Dario Leosco, Valeria Conti
Publikováno v:
Leosco, D, Rengo, G, Iaccarino, G, Golino, L, Marchese, M, Fortunato, F, Zincarelli, C, Sanzari, E, Ciccarelli, M, Galasso, G, Altobelli, G G, Conti, V, Matrone, G, Cimini, V, Ferrara, N, Filippelli, A, Koch, W J & Rengo, F 2007, ' Exercise promotes angiogenesis and improves beta adrenergic receptor signaling in the post-ischemic failing rat heart. ', Cardiovascular Research, vol. 2, no. 78, pp. 385-94 . https://doi.org/10.1093/cvr/cvm109
Aims: We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart. We also explored the contribution of ameliorated beta-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab2afbf123597d8fefff934770a11e
https://pubmed.ncbi.nlm.nih.gov/18093988
https://pubmed.ncbi.nlm.nih.gov/18093988
Autor:
Yves Donati, Jean Francois Tolsa, Morice Beghetti, Ferenc Peták, Constance Barazzone-Argiroffo, Eniko Lele, Gergely Albu, Isabelle Ruchonnet-Metrailler, Walid Habre
Publikováno v:
Respiratory Research, Vol 7, Iss 1, p 45 (2006)
Respiratory Research
Respiratory Research, vol. 7, pp. 45
Respiratory Research, Vol. 7 (2006) P. 45
Respiratory Research
Respiratory Research, vol. 7, pp. 45
Respiratory Research, Vol. 7 (2006) P. 45
Background As prolonged hyperoxia induces extensive lung tissue damage, we set out to investigate the involvement of endothelin-1 (ET-1) receptors in these adverse changes. Methods Experiments were performed on four groups of mice: control animals ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e494e417b40b99de8400c032f2eda9e7
http://respiratory-research.com/content/7/1/45
http://respiratory-research.com/content/7/1/45
Publikováno v:
Nature Neuroscience, Vol. 14, No 4 (2011) pp. 414-6
Nature neuroscience
Nature neuroscience
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a463f3067f45b6185721f8ace50d3bb9
https://pubmed.ncbi.nlm.nih.gov/21336270
https://pubmed.ncbi.nlm.nih.gov/21336270
Autor:
Luis Fernandez, Emmanuel Carrera, Neeraj Badjatia, J. Michael Schmidt, Randolph S. Marshall, Stephan A. Mayer, Jan Claassen, Kiwon Lee, Pedro Kurtz, E. Sander Connolly
Publikováno v:
Archives of Neurology, Vol. 67, No 4 (2010) pp. 434-439
To determine the predictors of impaired cerebrovascular reactivity (CVR) and the value of CVR in predicting delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH).Prospective observational study. We evaluated CVR during the following int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eb4868cb2020d7d17e97314982a147
https://doi.org/10.1001/archneurol.2010.43
https://doi.org/10.1001/archneurol.2010.43