Zobrazeno 1 - 10
of 48
pro vyhledávání: '"drug effects, Gene Expression Regulation"'
Autor:
Fabian Stahl, Dominik Piston, Bernd O. Evert, Laura de Boni, Peter Breuer, Ullrich Wüllner, Ina Schmitt, Philip Denner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific reports 11(1), 19857 (2021). doi:10.1038/s41598-021-98841-9
Scientific Reports
Scientific reports 11(1), 19857 (2021). doi:10.1038/s41598-021-98841-9
Scientific Reports
Multiplications, mutations and dysregulation of the alpha synuclein gene (SNCA) are associated with the demise of dopaminergic neurons and are considered to play important roles in the pathogenesis of familial and sporadic forms of Parkinson’s dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec5d42370fea8800212e633ffade676
https://doaj.org/article/35e23d580f6a483d801a8bf67c002435
https://doaj.org/article/35e23d580f6a483d801a8bf67c002435
Autor:
Waldemar A. Turski, Christopher A. Turski, Gabrielle N. Turski, Artur Wnorowski, Lechoslaw Turski
Publikováno v:
Restorative neurology and neuroscience 38(4), 343-354 (2020). doi:10.3233/RNN-201042
Restorative Neurology and Neuroscience
Restorative Neurology and Neuroscience
Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as cough, fever, malaise, headache, and anosmia. After entry into cells, corona viruses (CoV) activate aryl hydrocarbon receptors (AhRs) by an indoleamine 2,3-diox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3305cf20deb1ef8c83dd4bc3021d1d
https://doi.org/10.3233/rnn-201042
https://doi.org/10.3233/rnn-201042
Autor:
von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Schob, Stefan, Scherlach, Cordula, Sandalcioglu, Ibrahim Erol, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, E. Antonio, Huettelmaier, Stefan, Acker, Till, Mawrin, Christian
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Acta Neuropathologica Communications 8(1), 41 (2020). doi:10.1186/s40478-020-00912-x
Acta Neuropathologica Communications
Acta Neuropathologica Communications 8(1), 41 (2020). doi:10.1186/s40478-020-00912-x
Acta Neuropathologica Communications
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::306ca425261f423e431772a1a39f2e78
http://link.springer.com/article/10.1186/s40478-020-00912-x
http://link.springer.com/article/10.1186/s40478-020-00912-x
Autor:
Bart Everts, Leonard R. Pelgrom, Joost M. Lambooij, Isabel Stoetzel, Maria Embgenbroich, Joachim L. Schultze, Vanessa van Harmelen, Jonas Schulte-Schrepping, Hendrik J. P. van der Zande, Hanno Pijl, Kristian Händler, Lisa R. Hoving, Laura Schlautmann, Karin de Ruiter, Sven Burgdorf, Anna Zawistowska-Deniziak, Leonie Hussaarts, Ko Willems van Dijk, Bruno Guigas, Maria Yazdanbakhsh, Marjolein A. Wijngaarden, Noemí García-Tardón
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 118(31), e2103304118 (2021). doi:10.1073/pnas.2103304118
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 118(31). NATL ACAD SCIENCES
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 118(31). NATL ACAD SCIENCES
Proinflammatory activation of macrophages in metabolic tissues is critically important in the induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct functional role in both macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4853dd491738c9d4b4c81a0e54327c
https://hdl.handle.net/1887/3214620
https://hdl.handle.net/1887/3214620
Autor:
Anja U. Bräuer, Maria Vittoria Cubellis, Georg Fuellen, Jan Lukas, Anne-Katrin Giese, Arndt Rolfs, Mathias Ernst, Giuseppina Andreotti, Stephan Struckmann, Andreas Hermann, Linda Rebecca Haake, Anne-Marie Knospe, Claudia Cozma, Valentina Citro, Susanne Seemann, Chiara Cimmaruta, Dirk Koczan
Publikováno v:
Biochemical journal (Online) (2020). doi:10.1042/BCJ20190513
info:cnr-pdr/source/autori:Susanne Seemann ; Mathias Ernst ; Chiara Cimmaruta ; Stephan Struckmann ; Claudia Cozma ; Dirk Koczan ; Anne-Marie Knospe ; Linda R Haake ; Valentina Citro ; Anja U Bräuer ; Giuseppina Andreotti ; Maria V Cubellis ; Georg Fuellen ; Andreas Hermann ; Anne-Katrin Giese ; Arndt Rolfs ; Jan Lukas/titolo:Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypesin Fabry disease/doi:10.1042%2FBCJ20190513/rivista:Biochemical journal (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
The biochemical journal / Reviews 477(2), 359-380 (2020). doi:10.1042/BCJ20190513
Biochemical Journal
info:cnr-pdr/source/autori:Susanne Seemann ; Mathias Ernst ; Chiara Cimmaruta ; Stephan Struckmann ; Claudia Cozma ; Dirk Koczan ; Anne-Marie Knospe ; Linda R Haake ; Valentina Citro ; Anja U Bräuer ; Giuseppina Andreotti ; Maria V Cubellis ; Georg Fuellen ; Andreas Hermann ; Anne-Katrin Giese ; Arndt Rolfs ; Jan Lukas/titolo:Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypesin Fabry disease/doi:10.1042%2FBCJ20190513/rivista:Biochemical journal (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
The biochemical journal / Reviews 477(2), 359-380 (2020). doi:10.1042/BCJ20190513
Biochemical Journal
The lysosomal storage disorder Fabry disease is characterized by a deficiency of the lysosomal enzyme α-Galactosidase A. The observation that missense variants in the encoding GLA gene often lead to structural destabilization, endoplasmic reticulum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfda54713078b2d84fa25ecc480bef0a
https://doi.org/10.1042/bcj20190513
https://doi.org/10.1042/bcj20190513
Autor:
S Cantilena, Stefanie Meier, Darren Hargrave, David Michod, John Anderson, Jasper de Boer, Maria Victoria Niklison Chirou, Paolo Salomoni
Publikováno v:
Cell Death & Disease
Cell death & disease 12(8), 785 (2021). doi:10.1038/s41419-021-04078-9
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell death & disease 12(8), 785 (2021). doi:10.1038/s41419-021-04078-9
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However, the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352d109b5f0dbec2fa754da507bbd703
https://pubmed.ncbi.nlm.nih.gov/34381018
https://pubmed.ncbi.nlm.nih.gov/34381018
Autor:
Achraf, Ammar, Khaled, Trabelsi, Omar, Boukhris, Bassem, Bouaziz, Patrick, Müller, Jordan M, Glenn, Karim, Chamari, Notger, Müller, Hamdi, Chtourou, Tarak, Driss, Anita, Hökelmann
Publikováno v:
Nutrients, Vol 12, Iss 2872, p 2872 (2020)
Nutrients 12(9), 2872-(2020). doi:10.3390/nu12092872
Nutrients
Nutrients 12(9), 2872-(2020). doi:10.3390/nu12092872
Nutrients
Background: Recent anti-aging interventions have shown contradictory impacts of (poly)phenols regarding the prevention of cognitive decline and maintenance of brain function. These discrepancies have been linked to between-study differences in supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b4517b95bea90cdddb61e6471b94cf
https://www.mdpi.com/2072-6643/12/9/2872
https://www.mdpi.com/2072-6643/12/9/2872
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-20 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications 6(1), 110 (2018). doi:10.1186/s40478-018-0611-4
Acta Neuropathologica Communications
Acta Neuropathologica Communications 6(1), 110 (2018). doi:10.1186/s40478-018-0611-4
Amyloid beta (Aβ)-mediated synapse dysfunction and spine loss are considered to be early events in Alzheimer’s disease (AD) pathogenesis. N-methyl-D-aspartate receptors (NMDARs) have previously been suggested to play a role for Amyloid beta (Aβ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18abc6835f7da525a487705c26d9d75e
http://link.springer.com/article/10.1186/s40478-018-0611-4
http://link.springer.com/article/10.1186/s40478-018-0611-4
Autor:
Yun-Hee Youm, Christina Camell, Jil Sander, Kim Y. Nguyen, Emily L. Goldberg, Matthew S. Rodeheffer, John D. Elsworth, Joachim L. Schultze, Allison Wing, Chester W. Brown, Aileen Lee, Vishwa Deep Dixit, Olga Spadaro
Publikováno v:
Nature 550(7674), 119-123 (2017). doi:10.1038/nature24022
Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides, declines with age. The defect in the mobilization of free fatty acids in the elderly is accompanied by increased visceral adipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b729d134a34c8aa98ecfd59c70cce2f
https://doi.org/10.1038/nature24022
https://doi.org/10.1038/nature24022
Autor:
Ricarda Grzybowski, Erik Hanff, Rainer H. Böger, D. Tsikas, Kathrin Cordts, Christian Gerloff, Axel Neu, Ali Sasani, Chi-Un Choe, Dirk Isbrandt, Sönke Hornig, Edzard Schwedhelm
Publikováno v:
Amino acids 52(1), 73-85 (2019). doi:10.1007/s00726-019-02812-4
Statin-induced myopathy affects more than 10 million people worldwide. But discontinuation of statin treatment increases mortality and cardiovascular events. Recently, l-arginine:glycine amidinotransferase (AGAT) gene was associated with statin-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe4cb8e5eadb2c2955bef83ca8dd4f8