Zobrazeno 1 - 10
of 18
pro vyhledávání: '"drug dose escalation"'
Autor:
Alwiena Johanna Blignaut, Laura Iannuzzi, Mechthild M. Gross, Ellen Blix, Jette Aaroe Clausen, Jessica Pehlke-Milde, Anne Britt Vika Nilsen, Deirdre Daly, Eleni Hadjigeorgiou, Kerstin Uvnäs-Moberg, Sandra Morano, Martina Koenig-Bachmann, Susanne Grylka-Baeschlin, Barbara Baranowska, Katrien Beeckman, Karin Minnie, Anna Dencker, Iwona Kiersnowska
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 15, Iss 7, p e0227941 (2020)
PLOS ONE
PLoS ONE, Vol 15, Iss 7, p e0227941 (2020)
Objective: To compare synthetic oxytocin infusion regimens used during labour, calculate the International Units (IU) escalation rate and total amount of IU infused over eight hours. Design: Observational study. Setting: Twelve countries, eleven Euro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6179ceab2d9c9d36730cdaf90f988966
https://pubmed.ncbi.nlm.nih.gov/32722667
https://pubmed.ncbi.nlm.nih.gov/32722667
Autor:
Thomas Conrad, Thanh Bach, Jessie K. Kennedy, Armando E. Gonzalez, Larissa V. Stebounova, Hector H. Garcia, Kiran Gajurel, Daryl J. Murry, Greg Deye, Patricia L. Winokur, Walt Jones, Denice M. Hodgson-Zingman, John R. Horton, Ellen E. Codd, Effie Y.H. Nomicos, Guohua An, Robert H. Gilman, Dilek Ince
Cysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of anthelmintic drugs, has demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f203b7c43ba03e0341087ee72baa34
https://hdl.handle.net/20.500.12866/7396
https://hdl.handle.net/20.500.12866/7396
Publikováno v:
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Purpose: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt–Koyanagi–Harada disease. Methods: We present the clinical findings and diagnostic studies performed for three p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d973f16a2b8a842c891b8a5535aa8219
https://repository.urosario.edu.co/handle/10336/22717
https://repository.urosario.edu.co/handle/10336/22717
Autor:
Heikki Joensuu, Vesa Kataja, Petri Bono, Nicholas D. James, Christophe Massard, Teuvo L.J. Tammela, John Aspegren, Mika Mustonen, Karim Fizazi
Background: Patients with castration-resistant prostate cancer (CRPC) had extended responses to the androgen receptor antagonist ODM-201, in phase 1/2 studies. Objective: To evaluate the safety and antitumour activity of prolonged ODM-201 treatment i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f31ead530fe5f96bb2446347ca7978
https://trepo.tuni.fi/handle/10024/103403
https://trepo.tuni.fi/handle/10024/103403
Autor:
Enrico O. Purisima, Shafinaz F. Chowdhury, Isabelle Aubry, Michael D. Perron, H. Uri Saragovi, Michel L. Tremblay
Publikováno v:
Molecular Pharmacology. 85:553-563
CD45 is a receptor-like member of the protein tyrosine phosphatase (PTP) family. We screened in silico for small molecules binding at a predicted allosteric pocket unique to the CD45 intracellular domain, and validated inhibitors by in vitro phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13096147a8e216466d46a5f3c0e1a921
https://doi.org/10.1124/mol.113.089847
https://doi.org/10.1124/mol.113.089847
Autor:
Mario Cazzola, Maria Gabriella Matera
Publikováno v:
Drugs. 67:503-515
There has been a real interest recently in developing once-daily beta(2)-adrenoceptor agonists (ultra-long-acting beta(2)-adrenoceptor agonists [ultra-LABAs]) for treating asthma and chronic obstructive pulmonary disease (COPD) in an attempt to simpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95362163dd32e92c666dfd18390ef47
https://doi.org/10.2165/00003495-200767040-00002
https://doi.org/10.2165/00003495-200767040-00002
Autor:
Alessandra Casuccio, Salvatore Cillino, F Di Pace, M Cillino, N Guépratte, S Damiani, G Raimondi
PURPOSE: To investigate the long-term effectiveness and safety of botulinum neurotoxin A (BoNT-A) treatment in patients with blepharospasm (BEB), hemifacial spasm (HFS), and entropion (EN) and to use for the first time two modified indexes, 'botulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ac29675dae0e3f50b46cef59079958
http://hdl.handle.net/10447/49493
http://hdl.handle.net/10447/49493
Autor:
Briassoulis, E. Ch, Golfinopoulos, Vassilis, Karina, M., Papakostas, P., Pavlidis, Nicholas, Fountzilas, George
Publikováno v:
Anti-Cancer Drugs
This trial aimed to define a recommended safe dose (RSD) of weekly paclitaxel and irinotecan combined with carboplatin in patients with advanced cancer. Patients with advanced cancer were eligible for this trial. Dose-limiting toxicity (DLT) was cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8d1445d1b6f5018b921dda1a2c5071
http://olympias.lib.uoi.gr/jspui/handle/123456789/19325
http://olympias.lib.uoi.gr/jspui/handle/123456789/19325
Autor:
Briassoulis, E. Ch, Pappas, P., Puozzo, C., Ch, F. Tolis, Fountzilas, George, Dafni, U., Marselos, M., Pavlidis, Nicholas
Publikováno v:
Clinical Cancer Research
Aim: To determine the safe dose range and pharmacokinetics of metronomic oral vinorelbine and obtain preliminary data on biomarkers and efficacy in patients with advanced cancer. Methods: Successive cohorts of patients received escalated doses of ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e80984f8ac4eaea77b4fa871e19b19
https://pubmed.ncbi.nlm.nih.gov/19808873
https://pubmed.ncbi.nlm.nih.gov/19808873